A5101454810- MicroRNA in disease regulation
- Cardiac Ischemia and Reperfusion
- Circular RNAs in diseases
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Advanced Glycation End Products research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Autophagy in Disease and Therapy
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular and Diving-Related Complications
- Cell death mechanisms and regulation
- Endoplasmic Reticulum Stress and Disease
- RNA Interference and Gene Delivery
- Inflammasome and immune disorders
- Cancer, Lipids, and Metabolism
- Cardiovascular Syncope and Autonomic Disorders
- Renin-Angiotensin System Studies
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Congenital Heart Disease Studies
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Angiogenesis and VEGF in Cancer
- Ferroptosis and cancer prognosis
- Cardiac Imaging and Diagnostics
China Three Gorges University
2015-2024
Second Hospital of Yichang
2024
Yichang Central People's Hospital
2008-2023
Long noncoding RNA (lncRNA) MEG3 is an important tumor suppressor in several types of human cancers. However, the biological function and underlying mechanism vascular endothelial cells (VECs) remain unknown. In present study, we demonstrated functional importance lncRNA proliferation angiogenesis VECs. overexpression significantly suppressed vitro VECs, whereas knockdown had opposite effect. Furthermore, found that exerts its through negatively regulating miR-9 by acting as a microRNA...
Background: Myocardial apoptosis is heavily implicated in the myocardial damage caused by ischemia-reperfusion (I/R). Toll-like receptor 4 (TLR4) a potent inducer of these apoptotic cascades. In contrast, radioprotective 105 kDa protein (RP105) specific negative regulator TLR4 signaling pathways. However, precise mechanisms which RP105 inhibits myocardium via TLR4-associated pathways during I/R not fully understood. Methods: We utilized rat model ischemic reperfusion injury (MIRI). Animals...
Uncoupling protein 2 (UCP2), located in the mitochondrial inner membrane, is a predominant isoform of UCP that expressed heart and other tissues human rodent tissues. Nevertheless, its functional role during myocardial ischemia/reperfusion (I/R) not entirely understood. Ischemic preconditioning (IPC) remarkably improved postischemic recovery followed by reduced lactate dehydrogenase (LDH) release with simultaneous upregulation UCP2 perfused myocardium. We then investigated IPC-afforded...
Atherosclerotic plaque rupture, a primary cause of acute cardiovascular events, is fundamentally influenced by biomechanical forces. While ferroptosis, an iron-dependent form regulated cell death, has been implicated in atherosclerosis progression, its impact on biomechanics and stability remains poorly understood. We developed comprehensive model integrating ferroptotic parameters with structural mechanics. Human carotid endarterectomy specimens (n = 45) were analyzed using multi-modal...
Background/Aim: Oxidative stress plays a critical role in pathogenesis of the neointimal arterial hyperplasia. The aim study was to evaluate effects resveratrol (RSV) on vascular hyperplasia stimulated by oxidative damage. Methods: Balloon injury induced rats that were intraperitonealy exposed (1 mg/kg) 7 or 14 days after surgical procedure. Animals euthanized operation. blood level 8-iso-prostaglandin F2α, morphology as well expression monocyte chemotactic protein-1 and interleukin-6...
Toll-like receptor 4 (TLR4) serves as an important inducer of apoptotic and autophagic responses in myocardial ischemia/reperfusion (I/R) injury (MIRI). Radioprotective 105 kDa protein (RP105) is a specific inhibitor TLR4. However, the molecular mechanisms by which RP105 represses apoptosis autophagy through TLR4‑mediated signaling during I/R have not yet been fully elucidated. Therefore, present study, we aimed to examine whether adenovirus-mediated overexpression repressed inhibiting...
Previous studies have reported that microRNA-22 (miR-22) may be implicated in ischemia-reperfusion (I/R)-induced myocardial injury. Our previously published data also demonstrated miR-22 protect against I/R injury via anti-apoptosis rats by targeting cAMP response element-binding protein binding (CBP). However, the specific function of is far from fully elucidated. The present study was designed to investigate another cardioprotective signaling mechanism A total 40 adult male Sprague-Dawley...
Large intergenic long noncoding RNA p21 (lincRNA-p21) has recently shown to play an important role in biological functions. However, the of lincRNA-p21 vascular endothelial cells remains unclear. In present study, we investigated through gain- and loss-of-function studies found that promoted cell apoptosis induced cycle progression. Furthermore, acted as endogenous sponge by directly binding miR-130b decreased expression. addition, reversed inhibitory effect on growth cells. Taken together,...
Aim: Atherosclerosis (AS) characterized as a chronic inflammatory disease. Multiple immune cells and cytokines, such high mobility group protein (HMGB1), regulatory T (Treg) cells, helper (Th17) inflammation-related play key role in its pathophysiology. A large number of studies report that HMGB1 Th17 may promote atherosclerosis progression, whereas Treg protective atherosclerosis; thus, alterations the Treg/Th17 ratio exist diseases. Up till now, relationships between levels remain...
Micro RNAs (miRNAs) play a very important role in myocardial ischemia/ reperfusion injury (MIRI), including inflammation, apoptosis, and angiogenesis. Previous studies have demonstrated up-regulation of miR-327 renal ischemia/reperfusion MIRI. Via TargetScan, we found RP105 is possible target gene miR-327; our previous also confirmed that acted as cardioprotective protein MIRI by reducing inflammation. However, the regulatory effect on has not previously been proposed. In study, aimed to...
The long-term stimulation of hyperglycemia greatly increases the incidence vascular restenosis (RS) after angioplasty. Neointimal hyperplasia injury is pathological cause RS, but its mechanism has not been elucidated. MicroRNA-24 (miR-24) low expression in injured carotid arteries diabetic rats. However, role miR-24 system unknown. In this study, we explore whether over-expression could attenuate neointimal formation streptozotocin (STZ)-induced Adenovirus (Ad-miR-24-GFP) was used to deliver...