A5100666451- COVID-19 and Mental Health
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Advanced Neuroimaging Techniques and Applications
- Cardiac Ischemia and Reperfusion
- Mental Health Research Topics
- Posttraumatic Stress Disorder Research
- Psychosomatic Disorders and Their Treatments
- Sleep and related disorders
- Advanced MRI Techniques and Applications
- Maternal Mental Health During Pregnancy and Postpartum
- Healthcare professionals’ stress and burnout
- Child and Adolescent Psychosocial and Emotional Development
- Diabetes Treatment and Management
- Immune Response and Inflammation
- Mindfulness and Compassion Interventions
- Suicide and Self-Harm Studies
- Schizophrenia research and treatment
- Transplantation: Methods and Outcomes
- Treatment of Major Depression
- MicroRNA in disease regulation
- Electrostatic Discharge in Electronics
- Stuttering Research and Treatment
- Receptor Mechanisms and Signaling
- Autophagy in Disease and Therapy
Wuhan University
2016-2025
Renmin Hospital of Wuhan University
2016-2025
King's College London
2020-2024
First Hospital of Jilin University
2022-2023
Jilin University
2022-2023
First Affiliated Hospital of Hebei Medical University
2022
Hebei Medical University
2022
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2022
Second Military Medical University
2020-2021
Abstract To study the acute psychological effects of Coronavirus Disease 2019 (COVID-19) outbreak among healthcare workers (HCWs) in China, a cross-sectional survey was conducted HCWs during early period COVID-19 outbreak. The including symptoms depression, anxiety, and post-traumatic stress disorder (PTSD) were assessed using Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder (GAD-7) questionnaire, Impact Event Scale-Revised (IES-R). prevalence PTSD estimated at 15.0%,...
Toll-like receptor 4 (TLR4) serves as an important inducer of apoptotic and autophagic responses in myocardial ischemia/reperfusion (I/R) injury (MIRI). Radioprotective 105 kDa protein (RP105) is a specific inhibitor TLR4. However, the molecular mechanisms by which RP105 represses apoptosis autophagy through TLR4‑mediated signaling during I/R have not yet been fully elucidated. Therefore, present study, we aimed to examine whether adenovirus-mediated overexpression repressed inhibiting...
Demoralization is a form of psychological distress that may cause suicidal ideation. syndrome common among cancer patients, but there has been little empirical study on the association ideation with demoralization, depression, and anxiety in this population. This aims to investigate prevalence high demoralization patients mainland China contribution beyond impact self-report depression anxiety. In cross-sectional study, 303 were invited complete questionnaires. total, 14.5% participants...
Micro RNAs (miRNAs) play a very important role in myocardial ischemia/ reperfusion injury (MIRI), including inflammation, apoptosis, and angiogenesis. Previous studies have demonstrated up-regulation of miR-327 renal ischemia/reperfusion MIRI. Via TargetScan, we found RP105 is possible target gene miR-327; our previous also confirmed that acted as cardioprotective protein MIRI by reducing inflammation. However, the regulatory effect on has not previously been proposed. In study, aimed to...
Previous studies have revealed the frontoparietal network (FPN) plays a key role in imaging pathophysiology of bipolar disorder (BD). However, homogeneity (NH) FPN among mania (BipM), remitted (rBD), and healthy controls (HCs) remains unknown. The present study aimed to explore whether NH within can be used as an biomarker differentiate BipM from rBD predict treatment efficacy for patients with BipM.Sixty-six BD (38 28 rBD) 60 HCs participated resting-state functional magnetic resonance...
The impact of 2019 coronavirus disease (COVID-19) outbreak on mental health was widespread concern recently. present study aimed to exam sleep quality and posttraumatic stress symptoms (PTSS) potential influence factors in the first phases COVID-19 massive China. A snowball sampling technique used a total 2027 Chinese participated study. Demographic information, epidemic area contact history, PTSS data were collected with an internet-based cross-sectional survey. Results suggested that 59.7%...
Interleukin (IL)‑23, as a novel pro‑inflammatory cytokine, is important in several inflammatory diseases, including myocardial ischemia and reperfusion (I/R) injury, however, the underlying mechanism remains to be elucidated. The present study was designed investigate specific role of IL‑23 I/R whether Janus kinase 2/signal transducer activator transcription 3 (JAK2‑STAT3) signaling pathway, one downstream pathways IL‑23, IL‑17A were involved. Anesthetized rats underwent different treatments...
Background Depression in adolescents is more heterogeneous and less often diagnosed than depression adults. At present, reliable approaches to differentiating between who are not affected by lacking. This study was designed assess voxel-level whole-brain functional connectivity changes associated with adolescent an effort define imaging-based biomarker this condition. Materials methods In total, 71 major depressive disorder (MDD) age-, sex-, education level-matched healthy controls were...
Suicidal ideation (SI) is a direct risk factor for suicide in patients with depression. Regarding the emergence of SI, previous studies have discovered many factors, including childhood abuse as major public problem. Previous imaging demonstrated that SI or has effects on brain structure and function, respectively, but interaction between them not been fully studied. To explore effect abuse, 215 depressive disorder completed Childhood Trauma Questionnaire to evaluate Beck’s Scale Ideation...
Warm‑supplementing kidney yang (WSKY) is an herbal prescription that has been used in Traditional Chinese Medicine for the treatment of psychiatric conditions. A previous study by our group found WSKY significantly improved cognitive function schizophrenia patients. In present study, effects on and their underlying mechanisms were investigated. was administered to MK‑801‑induced rat model chronic 14 days. Memory performance assessed using Morris water maze (MWM) test. The expression...
To explore the influence of family-related factors on suicide-related behaviors patients with major depression disorder, and to provide scientific evidence for effective preventive measures.A total 852 outpatients at Renmin Hospital Wuhan University were enrolled in this cross-sectional study from April 2019 January 2021. The general demographic information collected via a questionnaire, Family Assessment Device, Egna Minnen av Barndoms Uppfostran, Childhood Trauma Questionnaire.Participants...
The radioprotective 105 kDa protein (RP105) has been implicated in the pathological process of multiple cardiovascular diseases through its functional and physical interactions with Toll‑like receptor 4 (TLR4). However, effects RP105 on cardiac microvascular endothelial cells (CMECs) response to hypoxia̸reoxygenation (H̸R) injury have not extensively investigated. aim present study was elucidate potential roles protection CMECs against H̸R injury, investigate underlying mechanisms. isolated...
Introduction Face-touching behaviour often happens frequently and automatically, poses potential risk for spreading infectious disease. Mindfulness-based interventions (MBIs) have shown its efficacy in the treatment of disorders. This study aims to evaluate an online mindfulness-based brief intervention skill named ‘STOP (Stop, Take a Breath, Observe, Proceed) touching your face’ reducing face-touching behaviour. Methods analysis will be online-based, randomised, controlled, trial. We...
Abstract Objectives Avoiding touching the eyes, nose, and mouth (T-zone) is a strategy to reduce spread of COVID-19. This study evaluated effectiveness brief mindfulness-based intervention (MBI) named “STOP (Stop, Take Breath, Observe, Proceed) your face” for reducing face-touching behavior. Methods In this online-based, two-arm, wait-list, randomized controlled trial, eligible participants were randomly assigned ( n = 545) or control group 545). The results 60-min self-monitoring behavior...
Background Despite the increasing prevalence of poor sleep quality among medical students, only few studies have identified factors associated with it sing methods from epidemiological surveys. Predicting is critical for ensuring Students’ good physical and mental health. The aim this study was to develop a comprehensive visual predictive nomogram predicting risk in students. Methods We investigated association at JiTang College North China University Science Technology through...