A5100709772- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Axon Guidance and Neuronal Signaling
- Blood Pressure and Hypertension Studies
- Coronary Interventions and Diagnostics
- Cardiovascular Disease and Adiposity
- Tissue Engineering and Regenerative Medicine
- Angiogenesis and VEGF in Cancer
- Electrospun Nanofibers in Biomedical Applications
- Acute Myocardial Infarction Research
- Cardiovascular and exercise physiology
- Cardiac Fibrosis and Remodeling
- Non-Invasive Vital Sign Monitoring
- Photoreceptor and optogenetics research
- Cardiovascular Health and Disease Prevention
- Vagus Nerve Stimulation Research
- Cardiac Valve Diseases and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Vascular Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
Wuhan University
2016-2025
Renmin Hospital of Wuhan University
2016-2025
China-Japan Friendship Hospital
2012-2025
Tianjin First Center Hospital
2024
Tianjin Medical University
2024
Fujian Medical University
2020-2024
First Affiliated Hospital of Fujian Medical University
2024
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
Semaphorin 4D (sema4D; CD100) is an integral membrane protein and the ligand for two receptors, CD72 plexin-B1. Soluble sema4D has been shown to evoke angiogenic responses from endothelial cells impair monocyte migration, but origin of soluble sema4D, particularly at sites vascular injury, unclear. Here we show that platelets express both its receptors provide evidence these molecules promote thrombus formation. We also surface expression increases during platelet activation, followed by...
The engineering of aggregation-induced emission luminogens (AIEgen) based covalent organic frameworks (COFs), TDTA-COF, BTDTA-COF, and BTDBETA-COF are reported, as hyperthermia agents for inhibiting the occurrence malignant ventricular arrhythmias (VAs). These AIE COFs exhibit dual functionality, they not only directly modulate function neural activity stellate ganglion (SG) through local therapy (LHT) but also induce browning white fat improve neuroinflammation peri-SG microenvironment,...
Abstract Autonomic imbalance is an important characteristic of patients after myocardial infarction (MI) and adversely contributes to post‐MI cardiac remodeling ventricular arrhythmias (VAs). A previous study proved that optogenetic modulation could precisely inhibit sympathetic hyperactivity prevent acute ischemia‐induced VAs. Here, a wireless self‐powered system introduced, which achieves long‐term precise neuromodulation in ambulatory canines. The optical based on triboelectric...
Chronic wound rescue is critical for diabetic patients but challenging to achieve with a specific and long-term strategy. The prolonged bacterial inflammation particularly prevalent in hyperglycemia-induced wounds, usually leading severe tissue damage. Such trend could further suffer from an environmental suitability provided by macrophages persisting Staphylococcus aureus (S. aureus) even deteriorate their mutual reinforcement. However, the strategy of both suppressing bacteria growth...
Background Digital education for outpatient patients with atrial fibrillation (AF) has gradually increased. However, research on digital undergoing catheter ablation (AFCA) is limited. Objective This study aimed to develop a novel animation-based multistage system and evaluate its quality-of-life benefits AFCA. Methods randomized controlled clinical trial included 208 AF who underwent in the Department of Cardiology at Renmin Hospital Wuhan University between January 2022 August 2023. The...
The ability of activated platelets to adhere each other at sites vascular injury depends on the integrin alpha(IIb)beta(3). However, as aggregation continues, signaling and adhesion molecules can contribute well. We have previously shown that human express their surface Eph receptor kinases EphA4 EphB1 kinase ligand ephrinB1. now show is physically associated with alpha(IIb)beta(3) in resting platelets, increases its expression when are activated, colocalizes contact between platelets. also...
Embryonic stem (ES) cells can terminally differentiate into all types of somatic and are considered a promising source seed for tissue engineering. However, despite recent progress in vitro differentiation vivo transplantation methodologies ES cells, to date, no one has succeeded using engineering generation tissues potential therapy.ES-D3 were cultured slow-turning lateral vessel mass production embryoid bodies. The bodies then induced cardiomyocytes medium supplemented with 1% ascorbic...
Myocardial infarction (MI) remains the leading cause of morbidity and mortality worldwide, novel therapeutic targets still need to be investigated alleviate myocardial injury ensuing maladaptive cardiac remodelling. Accumulating studies have indicated that lncRNA H19 might exert a crucial regulatory effect on cardiovascular disease. In this study, we aimed explore biological function molecular mechanism in MI. To investigate functions H19, miRNA-22-3p KDM3A, gain- loss-of-function...
Previous trials of renal denervation (RDN) have been designed to investigate reduction blood pressure (BP) as the primary efficacy endpoint using non-selective RDN without intraoperatively verified success. It is an unmet clinical need map nerves, selectively denervate sympathetic provide readouts for interventionalists and avoid futile RDN. We aimed examine safety nerve mapping/selective (msRDN) in patients with uncontrolled hypertension (HTN) determine whether antihypertensive drug burden...
Fifty-six balloon dilatations in 51 patients with upper-extremity dialysis access fistulas were performed over a 4-year period. Forty-four venous anastomotic lesions either internal or graft dilated. Three arterial and nine distant stenoses treated. Thirty-nine of 56 (70%) initially successful. Of the initial successes, 28/35 (80%) patent at 3 months, 19/27 6 12/22 (55%) 1 year, 7/14 (50%) 2 years, 3/9 (33%) years. complications (5%) encountered. These included two thromboses one...
Myocardial infarction (MI) and the subsequent heart failure remain one of leading causes morbidity mortality world wide. A number studies have demonstrated that bioderived materials improve cardiac function after implantation because their angiogenic potential. In this study, we hypothesized injection biomaterials into infarcted myocardium can preserve left ventricular (LV) through its prevention paradoxical systolic bulging. To test hypothesis, was induced in rabbit by coronary artery...
Introduction: The mechanism(s) underlying complex fractionated atrial electrograms (CFAE) is not well understood. We hypothesized that CFAE may be caused by enhanced activity of the intrinsic cardiac autonomic nervous system. Methods and Results: In 35 anesthetized dogs, via a right or left thoracotomy, sustained fibrillation was induced local application acetylcholine (ACh; 10, 100 mM) to surface appendage (AA) injection ACh (10 into ganglionated plexi (GP). Fast Fourier transform analysis...
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary heart disease characterized by fatty infiltration, life-threatening arrhythmias, and increased risk of sudden cardiac death. The guideline for management ARVC in patients to improve quality life reducing arrhythmic symptoms prevent However, the mechanism underlying ARVC-associated arrhythmias remains poorly understood.Using protein mass spectrometry analyses, we identified that integrin β1 downregulated hearts without...
Background The advantages of multimodal digitally transformed mobile health management for patients diagnosed with mild to moderate hypertension are not yet established. Objective We aim evaluate the therapeutic benefits a novel WeChat-based digital transforming model in blood pressure (BP) management. Methods This randomized controlled clinical trial included 175 individuals new-onset who were admitted our center between September and October 2022. randomly assigned either intervention...
In dyslipidemic states, platelets become hyperreactive, secreting molecules that promote atherosclerosis. We have shown the semaphorin family member, sema4D (CD100), is expressed on surface of and proposed its role includes promoting thrombus growth by binding to nearby endothelial cells, both which express receptors. Here we tested hypothesis deleting will attenuate adverse consequences dyslipidemia vessel wall.Platelet function atherosclerotic lesion formation were measured in LDLR(-/-)...
Renal sympathetic nerve (RSN) activity plays a key role in systemic hyperactivity. Previous studies have shown that cardiac hyperactivity, especially the left stellate ganglion (LSG), contributes to pathogenesis of ventricular arrhythmias (VAs) after acute myocardial infarction (AMI).Twenty-eight dogs received 3 hours continuous left-sided electrical stimulation RSN (LRS; Group-1, n = 9), sham (Group-2, or LSG ablation plus LRS (Group-3, 10) were included. AMI was induced by ligating...