Despite mounting experimental evidence that cyclosporine inhibits pancreatic islet cell function, clinical data on posttransplant diabetes mellitus (PTDM) in renal allograft recipients the era are scarce. Between June 1983 and December 1988, 39 of 337 (11.6%) cyclosporine-treated adult transplant recipient whose grafts survived longer than 1 year developed PTDM. Of these, 43.6% 74.4% were diagnosed by 3 12 months posttransplant, respectively, 51.3% insulin-dependent. Incidence PTDM was...

Background. This 36-month, randomized, parallel-group study compared safety and efficacy of two doses everolimus with mycophenolate mofetil (MMF) in de novo renal-transplant recipients. Methods. Renal-allograft recipients received 1.5 mg/day or 3 2 g/day MMF, plus full-dose cyclosporine (CsA) corticosteroids after randomization. For at least their first year, patients medication according to a double-blinded, double-dummy design. Concerns over nephrotoxicity led protocol amendment an...

Twenty-nine percutaneous balloon dilations of the axillary and subclavian veins were performed in 19 patients. Stenoses occurred typical locations anatomic narrowing or at sites previous trauma. The initial success rate was 76%, with a 1-year patency 35% 2-year 6%. Angioplasty can be on an outpatient basis very low significant complications repeated numerous times to keep vein patent for many years. This procedure is especially valuable dialysis patients who have limited access sites.

One hundred forty-one dilatations of stenotic lesions in dialysis access fistulas were performed. The initial success rate was 82%. one-year patency 45%, with a 2-year 24%. Best results obtained discrete stenosis at graft-to-vein anastomosis. procedure can be done on an outpatient basis and, although long-term are poor, appropriate patients multiple performed to keep fistula functioning for many years.

We retrospectively reviewed the course of 1,000 renal transplants performed in 835 recipients (758 nondiabetics) to assess incidence new onset posttransplant diabetes former nondiabetics. A total 119 (15.7%) manifested diabetes, whom 64 (53.8%) became hyperglycemic within 3 weeks transplantation. Actuarial survival analysis indicated a statistically significant selection blacks; 68 (57.1%) group diabetics contrasted with 30.4% overall series who were black (p = less than 0.01). Males...

The urinary proteome in health and disease attracts increasing attention because of the potential diagnostic pathophysiologic biomarker information carried by specific excreted proteins or their constellations. This cross-sectional study aimed to analyze patients with biopsy-proven acute rejection (<i>n</i> = 23) compared transplant recipients stable graft function 22) healthy volunteers 20) correlate this clinical, morphologic, laboratory data. Urine samples were preadsorbed on four...

Fifty-six balloon dilatations in 51 patients with upper-extremity dialysis access fistulas were performed over a 4-year period. Forty-four venous anastomotic lesions either internal or graft dilated. Three arterial and nine distant stenoses treated. Thirty-nine of 56 (70%) initially successful. Of the initial successes, 28/35 (80%) patent at 3 months, 19/27 6 12/22 (55%) 1 year, 7/14 (50%) 2 years, 3/9 (33%) years. complications (5%) encountered. These included two thromboses one...

Children with a well-functioning graft continue to show growth retardation even low-dose prednisone. We have attempted utilize the steroid-sparing effect of cyclosporine by discontinuing prednisone after stabilization. Since 1983, 53 children received as primary immunosuppressant for renal maintenance. The children, aged 6 months 18 years, 60 transplants. One-year and four-year patient survival cadaveric transplants was 91% 91%, compared 96% living related survivals were 82% 65% (n = 25),...

We previously demonstrated that 4.7 kDa and 4.4 peptides are useful in diagnosing acute rejection renal transplant recipients. The aim of this study was to characterize these polypeptides assess their potential as biomarkers. were identified human beta-Defensin-1 (4.7 kDa) alpha-1-antichymotrypsin (4.4 kDa), by tandem mass spectrometry ProteinChip immunoassay. urinary abundance both polypeptides, assessed using surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF MS),...

INGULLI, ELIZABETH; TEJANI, AMIR; BUTT, KHALID M. H.; RAJPOOT, DEEPAK; GONZALEZ, RAFAEL; POMRANTZ, ANDREW; ETTENGER, ROBERT Author Information

We studied the long-term outcome of a group children with nephrotic syndrome who showed histological lesion focal segmental glomerular sclerosis (FSGS) during course their illness. Of 25 such studied, complete follow-up ranging from 3 to 19 years was available in 24. Two distinct groups could be identified. Patients first were characterized by steroid resistance (SR) onset, whereas those second initially sensitive (SS), and had minimal change which, over time, evolved into FSGS. SR patients...

One-hundred twenty-five cases of upper extremity internal arteriovenous and graft fistulas were reviewed. Clinical problems requiring study poor fistula flow during dialysis, difficulty in cannulation, diminished pulsations, edema or varicosities, the appearance pulsatile nonpulsatile masses fistula, distal ischemia. Angiography demonstrated venous occlusion (13 cases), stenosis at near anastomotic site (32 thrombi within shunts (9 aneurysms pseudoaneurysms related to either proximal...

The present status and future prospects of uremia therapy in the United States are reviewed. Approximately 3500 renal transplants were done 1976 as compared to 3700 1975. Functional two-year survival grafts has not changed recently (40 45 per cent for cadaver donors; 70 75 siblings), but patient with continues improve (now 65 at two years). Patients on hemodialysis facilities increasing rapidly. Only 13 home dialysis, nearly 40 five years ago. Home patients do least well those centers (80...

Six strictures of the ureter were dilated with balloon angioplasty catheters. Two obstructed ureterovesical junctions in transplant patients successfully treated. One ureteropelvic junction a kidney redundant failed to respond. 2 uretero-ileostomy was treated, though one mid-ureteral stricture remained unchanged. Multiple dilatations necessary several patients. No significant complications noted. Pre- and post-dilatation assessment obstruction using Whitaker test helpful

A worldwide shortage of cadaveric donors has led to the increased utilization elderly living donors, with controversial results. In an attempt assess effect donor age on graft survival and subsequent renal function, we analyzed our clinical results in 276 consecutive recipients related transplants spanning both cyclosporine azathioprine eras, whom a total 44 received kidneys from over 55 years old. All were otherwise similar age, race, haplotype mismatch, number retransplants, pretransplant...

Eighty-four balloon dilatations of dialysis-access fistulas have been performed over a five year period. Fifty-two were done with polyethylene balloons and the last 32 high-pressure Olbert balloons. Initial success was significantly greater balloons, but long-term patency rates similar. Use long inflation times is method choice for dilating venostenotic lesions in access fistulas.

To investigate the impact of donor age on outcome renal transplants, a retrospective analysis 440 consecutive cadaver kidney transplants were performed by dividing into six groups, according to decade age. These groups comparable with regard recipient age, sex, race, and HLA matching grade, while pediatric group received kidneys preferentially from first second donors. Although between 11 50 years, did not appear influence result retrieved sixth or higher decades donors fared significantly...

We report a series of three cases pleomorphic adenoma with extensive lipometaplasia, recently described subtype salivary gland origin. Two patients were female and one male, ranging in age from 30 to 45 years. occurred the minor glands lip palate, respectively, parotid. Typical histologic findings are presented. In addition, case consists proliferation spindle cells an interesting combination mature adipose tissue, hyaline cartilage, bone absence ductal structures. The differential...