A5050838612- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Pancreatic function and diabetes
- Liver Disease and Transplantation
- Organ and Tissue Transplantation Research
- Cytomegalovirus and herpesvirus research
- Neurological Complications and Syndromes
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
- Diabetes Management and Research
- Immune Cell Function and Interaction
- Metabolism and Genetic Disorders
- Pharmacological Effects and Toxicity Studies
- Dialysis and Renal Disease Management
- Liver Disease Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Immunotherapy and Immune Responses
- Polyomavirus and related diseases
- Biochemical and Molecular Research
- Pregnancy and Medication Impact
- Xenotransplantation and immune response
University of Wisconsin–Madison
2014-2024
Marshfield Clinic
2022
Ospedale regionale di Lugano
2020
Medical University of Vienna
2020
Pioneer (United States)
2018
UW Health University Hospital
2001-2017
Public Health Department
2014
Fujita Health University
2014
University of Arizona
2014
Highland Community College - Illinois
1985-2011
In a retrospective analysis on 323 orthotopic liver transplant procedures performed between July 1984 and October 1991 the incidence of two forms primary dysfunction (PDF) liver: nonfunction (PNF), initial poor function (IPF) were studied. The PDF was 22% (73/323) with 6% PNF (20/323) 16% IPF (53/323), while 78% (250/323) had immediate (IF). Occurrence both resulted in higher graft failure rate (P < 0.001), retransplantation patient mortality 0.003) within first three months after OLTx....
Methods of accurately assessing the suitability donor livers prior to transplantation are required if incidence primary nonfunction (PNF) is be reduced. This study evaluated ability liver biopsies predict development after transplantation. From June 1987 until May 1990, 170 transplants were performed in 147 patients. A total 124 obtained and divided into three groups. Group 1 (n=77) revascularization liver, group 2 (n=19) hepatectomy but examined only implantation, 3 (n=28) as 2,...
Campath‐1H, an anti‐CD52 monoclonal antibody, was used as induction therapy (40 mg i.v. total dose) in 29 primary human renal transplants, and the patients were maintained on rapamycin monotherapy (levels 8–15 ng/mL) post‐transplant. Campath‐1H profoundly depletes lymphocytes long‐term more transiently B cells monocytes. All are alive well at 3–29 months of follow up. One graft lost because rejection. There have been no systemic infections malignancies. Eight experienced rejection, which...
To determine whether the outcomes of liver transplantation (LTx) from donation after cardiac death (DCD) donors are equivalent to those brain (DBD) donors.Because significant donor organ shortage, more transplant centers using livers recovered DCD donors. However, long-term, single-center limited.From January 1, 1993, July 31, 2002, 553 transplants were performed DBD and 36 Differences in event rates between groups compared with Kaplan-Meier estimates log-rank test. proportion differences...
This study evaluates the long-term outcomes, biliary complication rates, and risk factors for complications after liver transplantation from "donation cardiac death" (DCD) donors.Recent enthusiasm toward increased use of DCD donors' livers is mitigated by high rates. Predictive development remain incompletely defined.We performed a retrospective review 1157 brain (DBD) 87 transplants between January 1, 1993, December 31, 2008. Patient graft survivals rates within first year were compared DBD...
Simultaneous pancreas-kidney transplantation (SPK) is a procedure which frees the diabetic patient with end-stage nephropathy from dialysis and daily insulin injections. The purpose of this study to report long-term outcomes procedure, describe surgical medical complications.The analysis includes 1000 consecutive SPKs performed between 1985 2007. Bladder drainage was used in 390 patients enteric 610 patients. In 362 patients, SPK before initiation dialysis.Patient survival at 1, 10, 20 years...
From December 1985 to October 1997, 500 simultaneous pancreas-kidney transplants (SPKs) were performed at the University of Wisconsin. Bladder drainage (BD) was used in 388 and enteric (ED) 112. All pancreas preserved UW solution.Patient survival 1, 5, 10 years 96.4%, 88.6%, 76.3%; kidney function, 80.3%, 66.6%; 87.5%, 78.1%, 67.2%. Thrombosis occurred three four (0.6% 0.8%) primary nonfunction one (0.2%). There a 4.2% acute tubular necrosis rate for kidney. Conversion from BD ED required...
The introduction of mycophenolate mofetil (MMF) represented a major advance in transplant medicine, although optimal use may be limited by gastrointestinal (GI) side-effects. An enteric-coated formulation sodium (EC-MPS; myfortic) has been developed with the aim improving upper GI tolerability mycophenolic acid. Therapeutic equivalence EC-MPS (720 mg b.i.d.) and MMF (1000 b.i.d.), concomitant cyclosporine microemulsion (Neoral) corticosteroids, was assessed 423 de novo kidney patients...
SOLLINGER, HANS W.; DEIERHOI, MARK H.; BELZER, FOLKERT O.; DIETHELM, ARNOLD G.; KAUFFMAN, ROBERT S. Author Information
The immunosuppressive activity of RS-61443, a semisynthetic derivative mycophenolic acid, was examined in 33 canine renal allografts. Initial studies established that triple therapy consisting 20 mg/kg RS-61443 combination with 5 cyclosporine and 0.1 methylprednisolone the optimal to prevent graft rejection. median survival time 8.1±1.2 days dogs without treatment (n=5), 8.5±1.7 control group (CsA mg/kg, MP mg/kg; n=6), 36.0±9.6 monotherapy (40 n=6); 122.4±38.75 (n=16). Graft prolongation...
Background. This 36-month, randomized, parallel-group study compared safety and efficacy of two doses everolimus with mycophenolate mofetil (MMF) in de novo renal-transplant recipients. Methods. Renal-allograft recipients received 1.5 mg/day or 3 2 g/day MMF, plus full-dose cyclosporine (CsA) corticosteroids after randomization. For at least their first year, patients medication according to a double-blinded, double-dummy design. Concerns over nephrotoxicity led protocol amendment an...
The current organ shortage has made utilization of organs from less-than-ideal donors more common. Although several transplant centers use kidneys non-heart-beating (NHBDs), there been reluctance to extend the these extrarenal organs. Of 130 referred our procurement organization between January 1993 and May 1994, 16 (12.3%) were NHBDs. Organ retrieval 10 resulted in donation, 5 renal donation only, 1 no as a result prolonged warm ischemia (> 2 hr). A total 39 transplanted rapid en bloc...
A patient was found to be functionally tolerant of a maternal kidney allograft as evidenced by good graft function 5 years after cessation all immunosuppressive drug therapy. Despite normal in vitro proliferative and IL-2 responses, anti-donor 1° MLR cultures yielded little donor-specific CTL activity either bulk or limiting dilution analysis (LDA) cultures. Using polymerase chain reaction, the patient's PBL skin were contain donor-derived Bw6+ cells. Removal donor cells from with mAb...
Between May 1, 1993 and April 5, 1995, 154 pancreas allograft recipients at 9 institutions were given FK506 posttransplant. Three groups studied: (1) initially for induction maintenance therapy (n = 82), (2) switched to antirejection or rescue 61), (3) converted other reasons 11). Of 82 patients in the group, 7 (9%) had simultaneous bone marrow (BM) pancreas-kidney (SPK-BM) transplants, 54 (66%) SPK transplants without BM, 14 (17%) alone (PTA), after previous kidney (PAK). All but 1...
A patient was found to be functionally tolerant of a maternal kidney allograft as evidenced by good graft function 5 years after cessation all immunosuppressive drug therapy. Despite normal in vitro proliferative and IL-2 responses, anti-donor 1° MLR cultures yielded little donor-specific CTL activity either bulk or limiting dilution analysis (LDA) cultures. Using polymerase chain reaction, the patient's PBL skin were contain donor-derived Bw6+ cells. Removal donor cells from with mAb...
Objective To compare the outcome of simultaneous pancreas-kidney transplantation (SPK) and living related donor renal (LRD) in patients with diabetes. Summary Background Data It remains unanswered whether diabetic end-stage failure are better served by LRD or SPK. Methods Using a longitudinal database, data from all receiving cadaveric transplants SPKs January 1986 through 1996 were analyzed. Patient graft survival, early function, cause patient loss compared for 43 HLA-identical LRDs, 87...
A multicenter trial was conducted to evaluate the efficacy and safety of tacrolimus in treatment refractory renal allograft rejection. Renal transplant recipients experiencing biopsy-proven recurrent acute rejection were eligible if current episode corticosteroids. total 73 patients enrolled, whom 59 (81%) had previously received at least one course antilymphocyte antibody as therapy. One-year follow-up available 93% patients. Median time rescue therapy 75 days after transplantation (range,...
Background. Basiliximab (Simulect), a high-affinity chimeric, monoclonal antibody directed against the alpha chain of human interleukin-2 receptor (CD25), reduces incidence acute renal allograft rejection when used in combination with cyclosporine (Neoral) and steroids. This study was designed to compare safety efficacy basiliximab polyclonal anti-T-cell (ATGAM) therapy for prevention de novo transplant recipients. Methods. 1-year, open-label, randomized trial conducted recipients cadaveric...
RS-61443 (mycophenolate mofetil) inhibits a key enzyme fo the de novo synthesis of purine nucleotides in T and B lymphocytes. The purpose this study was to evaluate efficacy patients with refractory renal allograft rejection. Patients eligible for had previously undergone anti-rejection therapy high-dose steroids or OKT3 monoclonal antibody. All rejection episodes were proven by biopsy. Successful rescue achieved 52 (69%) patients. Rescue more successful when entered creatinine 4 mg/dL lower...
The urological complications of 210 patients who underwent simultaneous pancreas-kidney (SPK) transplantation over a 7-year period were reviewed.Worldwide, bladder drainage has become the accepted method exocrine after pancreas transplantation. With increasing use drainage, surgical post-transplant have shifted from intra-abdominal to complications.Two hundred ten diabetic received SPK transplants with drainage. A retrospective review was conducted analyze incidence, type, and management...