A5022388199- Electrochemical sensors and biosensors
- Renal Transplantation Outcomes and Treatments
- Electrochemical Analysis and Applications
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Electrocatalysts for Energy Conversion
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Renal and Vascular Pathologies
- Conducting polymers and applications
- Advanced battery technologies research
- Neurological Complications and Syndromes
- Microbial Fuel Cells and Bioremediation
- CO2 Reduction Techniques and Catalysts
- Advanced biosensing and bioanalysis techniques
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Analytical Chemistry and Sensors
- Transplantation: Methods and Outcomes
- Fuel Cells and Related Materials
- Cytomegalovirus and herpesvirus research
- Pregnancy and Medication Impact
- Liver Disease and Transplantation
- Prostate Cancer Diagnosis and Treatment
Michigan State University
2019-2025
Mohammed Bin Rashid University of Medicine and Health Sciences
2018-2024
University of Limerick
2023
University of Oklahoma
2010-2021
University Hospital Limerick
2021
University of Utah
2014-2020
Salt Lake Regional Medical Center
2015-2019
Beaumont Hospital
2006-2017
Argonne National Laboratory
2017
Universidade de Ribeirão Preto
2015
Most patients with metastatic prostate cancer will have metastasis to bone. Such are best monitored by serial radionuclide bone scans. One hundred sixty six men from who received androgen deprivation therapy had their pretreatment scans reviewed using a semiquantitative grading system based upon the extent of disease (EOD) observed on scan. The EOD scan correlated survival. 2-year survival rates for I IV were 94%, 74%, 68%, and 40%, respectively. in categories significantly differed other...
Reductive electrosynthesis has faced long-standing challenges in applications to complex organic substrates at scale. Here, we show how decades of research lithium-ion battery materials, electrolytes, and additives can serve as an inspiration for achieving practically scalable reductive electrosynthetic conditions the Birch reduction. Specifically, demonstrate that using a sacrificial anode material (magnesium or aluminum), combined with cheap, nontoxic, water-soluble proton source...
C–N cross-coupling is one of the most valuable and widespread transformations in organic synthesis. Largely dominated by Pd- Cu-based catalytic systems, it has proven to be a staple transformation for those both academia industry. The current study presents development mechanistic understanding an electrochemically driven, Ni-catalyzed method achieving this reaction high strategic importance. Through series electrochemical, computational, kinetic, empirical experiments, key features have...
Rationally designing quinones to label GDH and create a redox hydrogel that delivers high OCP, current power densities.
The deployment of nonaqueous redox flow batteries for grid-scale energy storage has been impeded by a lack electrolytes that undergo events at as low (anolyte) or high (catholyte) potentials possible while exhibiting the stability and cycling lifetimes necessary battery device. Herein, we report new approach to electrolyte design uses physical organic tools predictive targeting possess this combination properties. We apply identification pyridinium-based anolyte undergoes 1e– electrochemical...
The development of new methods to facilitate direct electron transfer (DET) between enzymes and electrodes is much interest because the desire for stable biofuel cells that produce significant amounts power. In this study, hydroxylated multiwalled carbon nanotubes (MWCNTs) were covalently modified with anthracene groups help orient active sites laccase allow DET. onset catalytic oxygen reduction current these biocathodes occurred near potential T1 site laccase, optimized produced...
We demonstrate the complete electrochemical oxidation of biofuel glycerol to CO2 using a hybrid enzymatic and small-molecule catalytic system. Combining an enzyme, oxalate oxidase, organic catalyst, 4-amino-TEMPO, we are able electrochemically oxidize at carbon electrode, while collecting up as many 16 electrons per molecule fuel. Additionally, investigate anomalous electrocatalytic properties that allow 4-amino-TEMPO be active under acidic conditions required for oxidase function.
Stable nitroxyl radical-containing compounds, such as 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) and its derivatives, are capable of electrocatalytically oxidizing a wide range alcohols under mild environmentally friendly conditions. Herein, we examine the structure–function relationships that determine catalytic activity diverse water-soluble radical compounds. A strong correlation is described between difference in electrochemical oxidation potentials compound electrocatalytic activity....
Increasing greenhouse gas emissions have resulted in greater motivation to find novel carbon dioxide (CO2 ) reduction technologies, where the of CO2 valuable chemical commodities is desirable. Molybdenum-dependent formate dehydrogenase (Mo-FDH) from Escherichia coli a metalloenzyme that able interconvert and . We describe low-potential redox polymer, synthesized by facile method, contains cobaltocene (grafted poly(allylamine), Cc-PAA) simultaneously mediate electrons Mo-FDH immobilize at...
Cobalt complexes have shown great promise as electrocatalysts in applications ranging from hydrogen evolution to C–H functionalization. However, the use of such often requires polydentate, bulky ligands stabilize catalytically active Co(I) oxidation state deleterious disproportionation reactions enable desired reactivity. Herein, we describe bidentate electronically asymmetric an alternative approach stabilizing transient species. Using rates electrochemically generated a model for...
Abstract Point-of-care sensors, which are low-cost and user-friendly, play a crucial role in precision medicine by providing quick results for individuals. Here, we transform the conventional glucometer into 4-hydroxytamoxifen therapeutic biosensor modulates electrical signal generated glucose oxidation. To encode within oxidation, introduce ligand-binding domain of estrogen receptor-alpha pyrroloquinoline quinone-dependent dehydrogenase constructing screening comprehensive protein insertion...
Aqueous redox flow batteries (ARFBs) are promising candidates for large-scale energy storage due to their high efficiency. Nafion ion-exchange membranes have been used in ARFB applications good ionic conductivity and excellent chemical mechanical stability, but Nafion's cost, excessive swelling, low ion selectivity limit its use commercialization. Amphoteric (AIEMs) potential preventing unwanted penetration, thus increasing selectivity. In our current work, we synthesized an economical...
The urological complications of 210 patients who underwent simultaneous pancreas-kidney (SPK) transplantation over a 7-year period were reviewed.Worldwide, bladder drainage has become the accepted method exocrine after pancreas transplantation. With increasing use drainage, surgical post-transplant have shifted from intra-abdominal to complications.Two hundred ten diabetic received SPK transplants with drainage. A retrospective review was conducted analyze incidence, type, and management...
Background. Delayed graft function (DGF) is a common complication in cadaveric kidney transplants affecting outcome. However, the incidence of DGF differs widely between centres as its definition very variable. The purpose this study was to define parameter for and immediate (IGF) compare outcome these groups at our centre.
Biofuel cells provide a safe and renewable means of powering small electronic devices. In this work, we demonstrate bioanode that is capable extracting four electrons from single molecule sucrose by way three-enzyme cascade. Invertase, fructose dehydrogenase glucose oxidase are immobilized in ferrocene-modified linear poly(ethylenimine) (LPEI) hydrogel onto the surface carbon electrode. Fuel sources generated polymer film (1) hydrolyzing into then (2) electroenzymatically oxidizing to...
We demonstrate a novel hydrogel material to facilitate direct bioelectrochemistry of wide range redox proteins and enable ATP-independent electroenzymatic reduction N<sub>2</sub> by nitrogenase.
We demonstrate a method to simultaneously immobilize the oxidation catalyst, TEMPO, while dramatically enhancing its electrocatalytic activity toward several biologically available alcohols. TEMPO is covalently immobilized onto linear poly(ethylenimine), which then cross-linked surface of glassy carbon electrode form hydrogel through substrates can readily diffuse. The TEMPO-LPEI used as an anode capable generating currents from 0.41 ± 0.06 mA cm–2 in presence 250 mM sucrose 8.20 0.04 2 M...
Establishing an efficient extracellular electron transfer (EET) process between photoelectroactive microorganisms and electrode surface is critical for the development of photobioelectrocatalysis. Soluble immobilized redox mediators have been applied with purple bacterium Rhodobacter capsulatus this purpose. However, detailed information on its EET not available and, therefore, choice has by trial error. Herein, we experimentally evaluated capability different soluble, quinone-based to...
Small implantable electronic devices require biologically compatible energy sources that are capable of delivering quick high-energy pulses. Combining batteries and supercapacitors allows for high power density while providing both small size biocompatibility. Here, we report a hybrid supercapacitor/biobattery whereby an oxygen-reducing cathode bilirubin oxidase immobilized with anthracene-modified carbon nanotubes tetrabutylammonium bromide-modified Nafion is coupled glucose bioanode flavin...