A5076326820- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Liver Disease Diagnosis and Treatment
- Renal and Vascular Pathologies
- Transplantation: Methods and Outcomes
- Hepatitis C virus research
- Cardiac Valve Diseases and Treatments
- Neurological Complications and Syndromes
- Metabolism and Genetic Disorders
- Cardiovascular Function and Risk Factors
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Congenital Anomalies and Fetal Surgery
- Iron Metabolism and Disorders
- Hematopoietic Stem Cell Transplantation
- Clinical Nutrition and Gastroenterology
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Pharmacological Effects and Toxicity Studies
- Pediatric Urology and Nephrology Studies
- Neonatal Health and Biochemistry
- Organ and Tissue Transplantation Research
- Liver Diseases and Immunity
- Central Venous Catheters and Hemodialysis
University of Washington
2010-2024
University of Washington Medical Center
2013-2017
Boston Medical Center
2015
University Medical Center
2015
Boston University
2015
Louisiana State University Health Sciences Center Shreveport
2015
Oregon Health & Science University
2006-2010
University of Portland
2010
University of Wisconsin–Madison
1995-2009
University of Iowa
1999-2007
Changes in organ allocation policy 2002 reduced the number of adult patients on liver transplant waiting list, changed characteristics recipients and increased receiving simultaneous liver-kidney transplantation (SLK). The transplants peaked 2006 declined marginally 2007 2008. During this period, there was an increase donor age, Donor Risk Index, candidates MELD exception scores with hepatocellular carcinoma. In contrast, a decrease retransplantation rates, grafts from either living or...
Quantitative measurements of arterial and venous blood flow were obtained with phase-contrast cine magnetic resonance (MR) imaging compared such by means implanted ultrasound (US) probes in anesthetized dogs. The US flowmeter was enabled during a portion each MR sequence to allow virtually simultaneous data acquisition the two techniques. gated electrocardiography divided into 16 phases per cardiac cycle. rates portal measured averaged across cycle (710 mL/min +/- 230 [standard deviation])...
Epidemiologic factors have generated increased demand for liver transplantation among older patients. We aimed to describe trends in age transplant registrants and recipients the effect of on waitlist post-transplantation outcomes transplant-related survival benefit.We obtained data from United Network Organ Sharing adults who were listed (N = 122,606) or underwent 60,820) 2002 2014 States. Competing risks analysis was used model Cox proportional hazards survival. These models also estimate...
Objective To compare the outcome of simultaneous pancreas-kidney transplantation (SPK) and living related donor renal (LRD) in patients with diabetes. Summary Background Data It remains unanswered whether diabetic end-stage failure are better served by LRD or SPK. Methods Using a longitudinal database, data from all receiving cadaveric transplants SPKs January 1986 through 1996 were analyzed. Patient graft survival, early function, cause patient loss compared for 43 HLA-identical LRDs, 87...
Our aim was to determine whether variant hepatic artery anatomy in a liver transplant recipient increases the risk of complications after transplantation.The study group consisted 84 patients who underwent gadolinium-enhanced 3D MR angiography before orthotopic transplantation which branch patch arterial anastomosis at gastroduodenal takeoff used. studies were retrospectively reviewed and assessed for presence type anatomy. The diameter distal common measured. incidence posttransplantation...
In hepatitis C virus (HCV)-positive liver transplant recipients, infection of the allograft and recurrent disease are important problems. Increased donor age has emerged as an variable affecting patient graft survival; however, specific cutoffs risk ratios for poor histologic outcomes survival not clear.A longitudinal database all HCV-positive patients transplanted at our center during 11-year period was used to identify 111 who received 124 transplants. Graft histological endpoints (severe...
Pancreas and kidney allograft function is routinely monitored with serum studies (amylase, lipase, creatinine). Increased levels commonly prompt tissue biopsy, to diagnose cause of graft dysfunction. Historically, pancreas allografts were infrequently biopsied, although enzymes renal rejection may be poor surrogates for status.Pancreas biopsies at our center reviewed reclassified according University Maryland (UMD) Banff criteria; C4d immunostaining was performed. Findings correlated...
Factors influencing the incidence of recurrent glomerulonephritis following renal transplantation are poorly understood. Bilateral pretransplant native nephrectomy has been advocated to reduce likelihood recurrence after transplant. However, there is significant morbidity in uremic population. Therefore, we sought determine effect on primary and attendant risk graft failure due disease. Three hundred sixty-four consecutive cadaveric (n = 214), living-related 137), living-unrelated 13)...
Decreases in endothelial nitric oxide synthase derived (NO) production during liver transplantation promotes injury. We hypothesized that preemptive inhaled NO (iNO) would improve allograft function (primary) and reduce complications post-transplantation (secondary). Patients at two university centers (Center A B) were randomized to receive placebo (n = 20/center) or iNO (80 ppm, n the operative phase of transplantation. Data analyzed set intervals for up 9-months compared between groups....
Significant geographic disparities exist in access to liver transplantation and consequently the current allocation system is being challenged. We sought describe our unique experience with using organs long cold ischemia times from largest donation service area.From 2009-2014 we performed 350 transplants. 167 (48%) had a time <8 hours, 134 (38%) between 8 12 49 (14%) greater than hours.Early allograft dysfunction was observed more commonly increasing times. 53% of recipients >12 h group...
This retrospective study reviews our experience in surveillance and early detection of cholangiocarcinoma (CC) using en bloc total hepatectomy-pancreaticoduodenectomy-orthotopic liver transplantation (OLT-Whipple) to achieve complete eradication early-stage CC complicating primary sclerosing cholangitis (PSC). Asymptomatic PSC patients underwent endoscopic ultrasound retrograde cholangiopancreatography (ERCP) with multilevel brushings for cytological evaluation. Patients diagnosed were...
The protective effect of the liver allograft when simultaneously transplanted with a kidney in setting allosensitization is unclear.We analyzed significance sensitization, defined based on positive cytotoxicity crossmatches, flow cytometry and/or presence high levels donor-specific antibodies, outcomes simultaneous and (SLK) transplantation. We reviewed 56 SLK performed at our center through December 31, 2011 identified 13 patients who met sensitization criteria.Median patient survival was...
Hyperammonemia syndrome, with high levels of ammonia and neurologic dysfunction, is a syndrome historically mortality that may occur after solid organ transplantation. Recently, this has been associated infection due to Ureaplasma, mostly following lung We describe the first case hyperammonemia Ureaplasma liver-kidney Our patient rapidly recovered specific antibiotic treatment. It important consider these infections in differential diagnosis for encephalopathy post-transplant, as organisms...
We first introduced the orthotopic liver transplantation utilizing cavaplasty technique in 1994. This paper describes surgical and assesses outcome of OLT.The procedure was used 115 consecutive transplantations, including six left lateral two right lobe between November 1994 September 2000. Fifty-three (66.3%) transplantations required femoro-axillary veno-venous bypass initial 4 years, whereas only eight (22.9%) needed VB subsequent 2 years. Conversion to piggyback or standard not necessary...
Abstract: Aim: Although hepatic iron deposition unrelated to hereditary hemochromatosis is commonly observed in cirrhosis, its clinical significance unclear. The aim of this study was examine the outcomes cirrhotic patients with and without hemosiderosis. Methods: Patients an initial liver biopsy demonstrating cirrhosis between January 1993 December 1997 were identified using Department Pathology database. Based on staining, characterized as siderotic or nonsiderotic. Charts reviewed...