A5001930460- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Polyomavirus and related diseases
- Hepatitis C virus research
- Vascular Procedures and Complications
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Renal and Vascular Pathologies
- Blood donation and transfusion practices
- Clinical Nutrition and Gastroenterology
- Congenital Anomalies and Fetal Surgery
- Esophageal and GI Pathology
- Viral-associated cancers and disorders
- Central Venous Catheters and Hemodialysis
- Palliative Care and End-of-Life Issues
- Frailty in Older Adults
- Cardiac, Anesthesia and Surgical Outcomes
- Potassium and Related Disorders
- Selenium in Biological Systems
- Folate and B Vitamins Research
- Intestinal and Peritoneal Adhesions
- Gallbladder and Bile Duct Disorders
University of Iowa Hospitals and Clinics
2010-2024
Mount Sinai Hospital
2015-2024
Mount Sinai Medical Center
2017-2023
Veterans Health Administration
2020-2023
University of Iowa
2004-2021
Iowa City VA Health Care System
2020
Pain and Rehabilitation Medicine
2018
Icahn School of Medicine at Mount Sinai
2017
Iowa City VA Medical Center
2017
Medigus (Israel)
2017
Medical Intelligence from The New England Journal of Medicine — Involvement JC Virus–Infected Mononuclear Cells the Bone Marrow and Spleen in Pathogenesis Progressive Multifocal Leukoencephalopathy
Some living kidney donors (LKDs) incur costs associated with donation, although these are not well characterized in the United States. We collected cost data 12 mo following donation from 182 LKDs participating multicenter prospective Kidney Donor Outcomes Cohort (KDOC) Study. Most (n = 167, 92%) had one direct or more including ground transportation (86%), health care (41%), meals (53%), medications (36%), lodging (23%), and air (12%). missed 33 072 total work hours, 40% of which were...
Our aim was to determine whether variant hepatic artery anatomy in a liver transplant recipient increases the risk of complications after transplantation.The study group consisted 84 patients who underwent gadolinium-enhanced 3D MR angiography before orthotopic transplantation which branch patch arterial anastomosis at gastroduodenal takeoff used. studies were retrospectively reviewed and assessed for presence type anatomy. The diameter distal common measured. incidence posttransplantation...
In hepatitis C virus (HCV)-positive liver transplant recipients, infection of the allograft and recurrent disease are important problems. Increased donor age has emerged as an variable affecting patient graft survival; however, specific cutoffs risk ratios for poor histologic outcomes survival not clear.A longitudinal database all HCV-positive patients transplanted at our center during 11-year period was used to identify 111 who received 124 transplants. Graft histological endpoints (severe...
More than 500,000 hospitalized patients survive severe sepsis annually in the USA. Recent epidemiological evidence, however, demonstrated that these survivors have significant morbidity and mortality, with 3-year fatality rates higher 70%. To investigate mechanisms underlying persistent functional impairment survivors, here we developed a model to study following cecal ligation puncture (CLP).
The purpose of this study was to assess the postnatal outcome and complications that arise in infants with prenatal diagnosis gastroschisis.Prenatal sonograms gastroschisis were identified. Maternal age, indication for sonography, gestational age at diagnosis, other sonographic abnormalities, recorded.Ninety-eight fetuses 14.3 36 weeks' gestation had on sonography. In 14 cases (14%), fetal anomalies identified, including hydronephrosis, hydrocephalus, coarctation aorta, a limb anomaly. Bowel...
Congenital disorders of glycosylation (CDG) arise from pathogenic mutations in over 100 genes leading to impaired protein or lipid glycosylation. ALG1 encodes a β1,4 mannosyltransferase that catalyzes the addition first nine mannose moieties form dolichol-lipid linked oligosaccharide intermediate required for proper N-linked cause rare autosomal recessive disorder termed ALG1-CDG. To date 13 18 patients 14 families have been described with varying degrees clinical severity. We identified and...
The bacterial flora intimately associated with the intestinal mucosa of patients Crohn's disease has been examined and compared mucosal a control group. Specimens were obtained at operation from undergoing surgery. Whole thickness sections taken diseased segment portion uninvolved intestine as well A section each specimen was histologically. Twenty-two specimens tissue (12 ileum, 10 colon) 46 samples small large bowel using strictly anaerobic bacteriological techniques in an chamber....
Prior studies demonstrate that most living kidney donors (LKDs) report no adverse psychosocial outcomes; however, changes in functioning at the individual donor level have not been routinely captured. We studied outcomes predonation and 1, 6, 12, 24 months postdonation 193 LKDs 20 healthy controls (HCs). There was minimal to mood disturbance, body image concerns, fear of failure, or life dissatisfaction, indicating incremental these over time significant differences between HCs. The...
United Network for Organ Transplantation (UNOS) policy 3.6.4.5.1 provides exception points to patients diagnosed with hepatopulmonary syndrome (HPS) compensate their reported increased mortality risk. We compared pre- and posttransplant overall outcomes in 255 receiving under this (HPS patients) 32 358 nonexception control listed the model end-stage liver disease (MELD) era determine whether intent of is being met. Overall, 92.5% HPS versus 45.5% controls had been transplanted, 5.1% 31.2%...
Curcumin, green tea polyphenols and selenium possess anti-inflammatory anti-oxidant properties. Individually they have demonstrated some efficacy in animal models human subjects with inflammatory bowel disease (IBD). To evaluate the safety of Coltect [Curcumin (500 mg), (250 mg) (100 µg)] vivo patients ulcerative colitis (UC).Each component was compared to placebo a DSS mice model. The validated 2,4,6-trinitrobenzenesulfonic acid (TNBS) rat Twenty mild-to-moderate UC received two tablets...
Increased use of pediatric deceased donor kidneys could enlarge the kidney pool. Kidney transplant outcomes from small donors were compared with those ideal (IK) and expanded criteria (ECK) to understand optimal kidneys.Kaplan-Meier analyses long-term patient death-censored graft survival en bloc (EBK) split (SpK) transplants (aged ≤8 y weight <30 kg) IK ECK. Posttransplant serum creatinine) was among these cohorts. Deceased disposition determined ≥1 organ transplanted.Patient similar...
This study sought to identify the prevalence, pattern, and predictors of clinical fatigue in 193 living kidney donors (LKDs) 20 healthy controls (HCs) assessed at predonation 1, 6, 12, 24 months postdonation. Relative HCs, LKDs had significantly higher severity (P = .01), interference .03), frequency .002), intensity lower vitality < .001), 1-month Using published criteria, more experienced 1 month postdonation, compared on both Fatigue Symptom Inventory (60% vs. 37%, P .001) SF-36 Vitality...
Placenta accreta spectrum (PAS) disorder is a potentially life-threatening condition that can occur during pregnancy. PAS puts pregnant individuals at very high risk of major blood loss, hysterectomy, and intensive care unit admission. These patients should receive in center with multidisciplinary experience expertise managing disorder. Obstetric anesthesiologists play vital roles the peripartum suspected PAS. As well as providing high-quality anesthesia care, obstetric coordinate...