A5057697494- Ectopic Pregnancy Diagnosis and Management
- Prenatal Screening and Diagnostics
- Congenital Heart Disease Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Thyroid Cancer Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Congenital Diaphragmatic Hernia Studies
- Cardiovascular Issues in Pregnancy
- Congenital Anomalies and Fetal Surgery
- Head and Neck Anomalies
- Urological Disorders and Treatments
- Maternal and fetal healthcare
- Ovarian cancer diagnosis and treatment
- Fetal and Pediatric Neurological Disorders
- Aortic Disease and Treatment Approaches
- Thyroid and Parathyroid Surgery
- Birth, Development, and Health
- Radiology practices and education
- Ultrasound in Clinical Applications
- Tracheal and airway disorders
- Pediatric Urology and Nephrology Studies
- Gynecological conditions and treatments
- Testicular diseases and treatments
- Neonatal Respiratory Health Research
- BRCA gene mutations in cancer
Brigham and Women's Hospital
2016-2025
Harvard University
2015-2024
Thomas Jefferson University
2018-2024
University of Southern California
2023-2024
Texas Children's Hospital
2018-2024
Baylor College of Medicine
2018-2024
Northeast Ohio Medical University
2019-2024
University of Alabama at Birmingham
2019-2024
University of Alabama
2018-2024
John Wiley & Sons (United States)
2023-2024
BACKGROUND. The diagnostic evaluation of patients with thyroid nodules is imprecise. Despite the benefits fine-needle aspiration (FNA), most who are referred for surgery because abnormal cytology prove to have benign disease. Recent technologic and procedural advances suggest that this shortcoming can be mitigated, although few data confirm benefit in unselected patients. METHODS. A total 2587 sequential were evaluated by ultrasound offered ultrasound-guided FNA (UG-FNA) all measured ≥1 cm...
Objective: The objective of this study was to determine the prevalence, distribution, and sonographic features thyroid cancer in patients with solitary multiple nodules.
Preventing the progression of fetal aortic stenosis (AS) to hypoplastic left heart syndrome (HLHS) requires identification fetuses with salvageable hearts who would progress HLHS if untreated, a successful in utero valvotomy, and demonstration that valvotomy promotes growth utero. Fetuses meeting first criterion are undefined, previous reports AS dilation have not evaluated impact intervention on structures.We offered 24 mothers whose had AS. At least 3 echocardiographers assigned high...
Aortic stenosis in the midgestation fetus with a normal-sized or dilated left ventricle predictably progresses to hypoplastic heart syndrome when associated certain physiological findings. Prenatal balloon aortic valvuloplasty may improve growth and function, possibly preventing evolution syndrome.Between March 2000 October 2008, 70 fetuses underwent attempted for critical evolving syndrome. We analyzed this experience determine factors procedural postnatal outcome. The median gestational...
Thyroid nodule size is routinely measured, although its impact on thyroid cancer risk unclear.Our objective was to evaluate the association of upon risk.We conducted a retrospective cohort analysis at an academic hospital with 4955 consecutive patients evaluated between 1995 and 2009.Ultrasound ultrasound-guided fine-needle aspiration nodules >1 cm done. Indeterminate malignant were referred for surgery, histopathology reviewed.The presence histological subtype evaluated.Of 7348 nodules, 927...
Thyroid cancer is the most common endocrine malignancy, but due to its rare occurrence in pediatric population, risk of childhood thyroid nodules incompletely defined, and optimal management children with suspected debated.The aim was study presenting features sporadic using a standardized clinical assessment plan.Boston Children's Hospital Brigham Women's collaborated create multidisciplinary nodule clinic implement plan. Upon referral for nodule, serum TSH measured hypothyrotropinemic...
Significance Newborns can hear their mother’s voice and heartbeat sounds before birth. However, it is unknown whether, how early, to what extent the newborn's brain shaped by exposure such maternal sounds. This study provides evidence for experience-dependent plasticity in auditory cortex preterm newborns exposed authentic recordings of full-term maturation. We demonstrate that more adaptive womb-like than environmental noise. Results are supported biological fact would otherwise be present...
Fetal aortic valvuloplasty can be performed for severe midgestation stenosis in an attempt to prevent progression hypoplastic left heart syndrome (HLHS). A subset of patients has achieved a biventricular (BV) circulation after fetal valvuloplasty. The postnatal outcomes and survival the BV patients, comparison with those managed as HLHS, have not been reported.We included 100 who underwent evolving HLHS from March 2000 January 2013. Patients were categorized based on management or HLHS....
Abstract Thyroid nodules are common. Evaluation of patients with thyroid typically includes fine needle aspiration biopsy (FNA), an approach that has proven to be accurate for the detection cancer. Although majority biopsies adequate a cytological diagnosis, up 20% will insufficient or nondiagnostic. Current opinion suggests such aspirates should repeated, although no systematic study investigated usefulness this approach, especially when ultrasound guidance is used direct initial FNA. We...
Objective. To determine whether color Doppler interrogation of a thyroid nodule can aid in the prediction malignancy. Methods. We obtained images nodules undergoing sonographically guided fine-needle aspiration. The appearance each was graded from 0 for no visible flow through 4 extensive internal flow. size, sonographic appearance, results aspiration, and surgical pathologic findings, if available, were recorded nodule. Results. There 254 sampled, which 32 malignant (all confirmed at...
Background: Thyroid nodules are common and most often benign. The natural history of benign thyroid nodules, however, is unclear. Objective: To determine the cytologically using ultrasonography. Design: Retrospective case series. Setting: Single tertiary care clinic. Participants: All patients referred to Brigham Women's Hospital Nodule Clinic, Boston, Massachusetts, who had cytologic results on ultrasonography-guided fine-needle aspiration a nodule between 1995 2000 returned for requested...
Cerebellar hemorrhage (CBH) in premature infants is increasingly diagnosed secondary to improved neuroimaging techniques and survival of very small preterm infants. Information limited, however, on the incidence, topography, risk factors for CBH infant. Objectives. To define incidence by neonatal cranial ultrasound (US), describe sonographic features CBH, identify maternal perinatal associated with this lesion. Methods. A systematic electronic database search identified born 1998–2002 US...
Infants born with hypoplastic left heart syndrome and an intact or highly restrictive atrial septum face a neonatal mortality of at least 48% despite early postnatal decompression palliative surgery. Prenatal has been suggested as means improving these outcomes. This study reports the feasibility fetal catheterization to create interatrial communication describes technical considerations.Seven fetuses 26 34 weeks' gestation underwent attempted prenatal intervention. Under ultrasound...
To determine the gray-scale and Doppler sonographic features that best enable discrimination between malignant benign ovarian masses develop a scoring system for accurate diagnosis with these features.Gray-scale of 211 adnexal were correlated final diagnosis; most discriminating malignancy selected stepwise logistic regression.Twenty-eight 183 benign. All markedly hyperechoic solid component or no For nonhyperechoic component, additional allowed statistically significant benignity from were,...
The Society of Radiologists in Ultrasound convened a panel specialists from variety medical disciplines to come consensus on the management thyroid nodules identified with ultrasonography (US), particular focus which should be subjected US-guided fine needle aspiration and need not fine-needle aspiration. met Washington, DC, October 26-27, 2004, created this statement. recommendations statement, are based analysis current literature common practice strategies, thought represent reasonable...
Conventional cytogenetic testing offers low-resolution detection of balanced karyotypic abnormalities but cannot provide the precise, gene-level knowledge required to predict outcomes. The use high-resolution whole-genome deep sequencing is currently impractical for purpose routine clinical care. We show here that "jumping libraries" can offer an immediately applicable, nucleotide-level complement conventional genetic diagnostics within a time frame allows action. performed large-insert DNA...
OBJECTIVES. Periventricular hemorrhagic infarction is a serious complication of germinal matrix-intraventricular hemorrhage in premature infants. Our objective was to determine the neurodevelopmental and adaptive outcomes periventricular survivors identify early cranial ultrasound predictors adverse outcome. METHODS. We retrospectively evaluated all ultrasounds 30 infants with assigned ultrasound–based severity score (range: 0–3) on basis whether (1) involved ≥2 territories, (2) bilateral,...