A5090197382- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Electrolyte and hormonal disorders
- Kidney Stones and Urolithiasis Treatments
- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Renal function and acid-base balance
- Heart Failure Treatment and Management
- Vascular Procedures and Complications
- Pharmacological Effects and Toxicity Studies
- Chronic Kidney Disease and Diabetes
- Pediatric Urology and Nephrology Studies
- Potassium and Related Disorders
- Ion Transport and Channel Regulation
- Sepsis Diagnosis and Treatment
- Healthcare cost, quality, practices
- Complement system in diseases
- Acute Kidney Injury Research
- Neonatal Health and Biochemistry
- Organ Donation and Transplantation
- Metabolism and Genetic Disorders
- Hormonal Regulation and Hypertension
- Bariatric Surgery and Outcomes
- Nephrotoxicity and Medicinal Plants
- Cardiac Arrest and Resuscitation
Baystate Medical Center
2014-2025
University of Massachusetts Chan Medical School
2019-2024
Baystate Health
2020-2023
Kidney Associates
2020-2021
Tufts University
2007-2018
Boston University
2015-2018
Boston Medical Center
2015
University Medical Center
2015
Louisiana State University Health Sciences Center Shreveport
2015
National Kidney Foundation
2013
<h3>Context</h3>The arteriovenous fistula is the preferred type of vascular access for hemodialysis because lower thrombosis and infection rates health care expenditures compared with synthetic grafts or central venous catheters. Early failure fistulas due to inadequate maturation a barrier increasing prevalence among patients treated hemodialysis. Small, inconclusive trials have suggested that antiplatelet agents may reduce new fistulas.<h3>Objective</h3>To determine whether clopidogrel...
Arteriovenous graft stenosis leading to thrombosis is a major cause of complications in patients undergoing hemodialysis. Procedural interventions may restore patency but are costly. Although there no proven pharmacologic therapy, dipyridamole be promising because its known vascular antiproliferative activity.We conducted randomized, double-blind, placebo-controlled trial extended-release dipyridamole, at dose 200 mg, and aspirin, 25 given twice daily after the placement new arteriovenous...
Currently, physicians are limited in their ability to provide an accurate prognosis for COVID-19 positive patients. Existing scoring systems have been ineffective identifying patient decompensation. Machine learning (ML) may offer alternative strategy. A prospectively validated method predict the need ventilation patients is essential help triage patients, allocate resources, and prevent emergency intubations associated risks. In a multicenter clinical trial, we evaluated performance of...
Antibiotic locks in catheter-dependent chronic hemodialysis patients reduce the rate of catheter-related blood stream infections (CRIs), but there are no data regarding long-term consequences this practice.Over a 4-year period, from October 1, 2002, to September 30, 2006, we initiated gentamicin and heparin lock (GHL) protocol 1410 receiving dialysis through tunneled catheter eight outpatient units.Within first year GHL protocol, our CRI decreased 17 0.83 events per 1000 catheter-days....
Acute kidney injury (AKI) is common among hospitalized patients and has a significant impact on morbidity mortality. Although early prediction of AKI the potential to reduce adverse patient outcomes, it remains difficult condition predict diagnose. The purpose this study was evaluate ability machine learning algorithm for as defined by Kidney Disease: Improving Global Outcomes (KDIGO) stage 2 or 3 up 48 hours in advance onset using convolutional neural networks (CNNs) electronic health...
Background Racial disparities in health care are well documented the United States. As machine learning methods become more common settings, it is important to ensure that these do not contribute racial through biased predictions or differential accuracy across groups. Objective The goal of research was assess a algorithm intentionally developed minimize bias in-hospital mortality between white and nonwhite patient Methods Bias minimized preprocessing training data. We performed...
Hyperkalemic Periodic Paralysis (hyperPP) is an autosomal dominant genetic disorder where high extracellular potassium associated with skeletal muscle depolarization and both flaccid weakness as well delayed relaxation that can lead to myotonia myopathy. Interventions have typically relied on avoidance of triggers, low diets, diuretics like acetazolamide diclofenamide limited success. The patient a 48 year old man hyperPP from familial sodium channel point mutation in the SCN4A gene at...
Extended-release dipyridamole plus low-dose aspirin (ERDP/ASA) prolongs primary unassisted graft patency of newly created hemodialysis arteriovenous grafts, but the individual contributions each component are unknown. Here, we analyzed whether use at baseline associated with among participants in a randomized trial that compared ERDP/ASA and placebo grafts. We used Cox proportional hazards regression, adjusting for prespecified comorbidities covariates. Of all participants, 43% reported...
Renal calcifications have been described in very low birth weight (VLBW) infants, and diuretic drugassociated hypercalciuria is believed to play a role the pathogenesis of this lesion. Hyperoxaluria an improtant cause renal stone formation children adults. Because parenteral nutrition solutions contain oxalate precursors ascorbate glycine, relationship between total administration excretion VLBW infants was examined. Administration approximately 0.5 g protein per kilogram day associated with...
Abstract Background Syndrome of apparent mineralocorticoid excess (AME) is characterized by excessive MR stimulation despite low levels aldosterone. 11Beta-hydroxysteroid dehydrogenase-2 (11βDSH-2) inactivates cortisol to cortisone, preventing cortisol-induced activation. Genetic defects in 11βDSH-2 cause AME through accumulation the distal nephron, leading activation induced hypertension, hypokalemia and metabolic alkalosis. Acquired can occur due ingestion glycyrrhizic acid, found licorice...