A5045386706- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Head and Neck Surgical Oncology
- Nasal Surgery and Airway Studies
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Respiratory and Cough-Related Research
- Cerebrospinal fluid and hydrocephalus
- Obstructive Sleep Apnea Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Drug-Induced Adverse Reactions
- Cystic Fibrosis Research Advances
- Inhalation and Respiratory Drug Delivery
- Otitis Media and Relapsing Polychondritis
- Ultrasound in Clinical Applications
- Cholinesterase and Neurodegenerative Diseases
- Meningioma and schwannoma management
- Bone Tumor Diagnosis and Treatments
- IgG4-Related and Inflammatory Diseases
- Tumors and Oncological Cases
- Oral and Maxillofacial Pathology
- Tracheal and airway disorders
- Vascular Anomalies and Treatments
- Nuclear Receptors and Signaling
Northwestern University
2016-2025
National University of Singapore
2020-2021
Northwestern Medicine
2021
Crozer-Keystone Health System
2019-2020
Vanderbilt University Medical Center
2020
Welch Foundation
2020
University of Mississippi Medical Center
2020
State Street (United States)
2020
American College of Allergy, Asthma and Immunology
2020
University Hospital and Clinics
2017
The medical records, premortem biopsy specimens, and autopsy materials from 36 patients with acquired immune deficiency syndrome (AIDS) were reviewed. majority of the homosexual men. Widely metastatic Kaposi's sarcoma was seen in eight patients, while tumor confined to skin an additional ten. Four had high-grade lymphomas. Thirty-five at least one opportunistic infection some point course their illness. Many multiple infectious agents. most consistent striking finding a severe depletion...
The aim of this study was to review complications occurring as a result endoscopic sinus surgery by one surgeon in an academic practice during 25-year period.Retrospective clinical study.A register tabulated period 25 years for performed chronic rhinosinusitis 3,402 patients (6,148 sides). All were reviewed whole and not divided into major or minor categories.A total 105 found have complicated surgery, overall patient complication rate 0.031, 0.017 per operated side. most common hemorrhage...
Abstract Background Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is characterized by type 2 inflammation high levels of Th2 cytokines. Although T helper cytokines are released from cells, innate lymphoid cells (ILC) also known to produce the same However, presence various types ILC in CRS poorly understood. Objective The objective this study was fully characterize all subsets and identify phenotypical differences group (ILC2) CRSwNP compared ILC2 non‐type inflamed areas. Methods...
State-dependent changes in upper airway caliber were studied with magnetic resonance imaging (MRI) techniques. We hypothesized that during sleep normal subjects would result from positional and dimensional soft-tissue structures, including the lateral pharyngeal walls, tongue, soft palate. used MRI to study 15 wakefulness sleep. Sleep was facilitated by one night of deprivation prior MRI. During sleep, volume retropalatal (RP) reduced 19% (p = 0.03). The retroglossal (RG) not significantly...
We utilized novel three-dimensional volumetric analysis techniques with magnetic resonance imaging (MRI) to study the upper airway and surrounding soft-tissue structures. These MRI allowed us objectively quantify volume of tongue, soft palate, parapharyngeal fat pads, lateral pharyngeal walls.We first validated our on a phantom then demonstrated that results were reliable reproducible in normal subjects who did not lose weight. Finally, we studied 12 obese, nonapneic women during wakefulness...
Background The delivery of topical intranasal corticosteroid sprays has traditionally been the primary method treating recurrent nasal polyposis. An emerging treatment for polyposis is budesonide irrigations. Delivered at concentrations nearly 100 times greater than found in prescription sprays, there have little studies on effects irrigation adrenal axis. Therefore, we investigated whether with solution was associated any increase serum cortisol and 24-hour urinary levels. Methods Patients...
Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by tissue eosinophilia that associated poor prognosis. Recent findings proton pump inhibitors (PPIs) directly modulate the expression of eotaxin-3, an eosinophil chemoattractant, in patients eosinophilic diseases suggest therapeutic potential for PPIs those CRSwNP.We assessed effect type 2 mediators, particularly IL-13 and on disease severity chronic (CRS). Further investigation focused PPI suppression eotaxin-3 vivo...
Summary Background B cells play many roles in health and disease. However, little is known about the mechanisms that drive cell responses airways, especially humans. Chronic rhinosinusitis ( CRS ) an inflammatory disease of upper airways affects 10% Europeans Americans. A subset patients develop nasal polyps NP s), which are characterized by type 2 inflammation, eosinophils group innate lymphoid ILC 2s). We have reported contain elevated levels antibodies, making ideal system for studying...
Chronic rhinosinusitis (CRS) is a syndrome defined by both symptomatic presentation and objective findings, such as those visible on endoscopy computed tomography (CT). These symptoms, endoscopic radiographic measures, are important for guiding surgical decision-making widely used post-operative surveillance. The severity of CRS CT findings respectively, quantified using validated tools like the sinonasal outcomes test-22 (SNOT-22), Lund–Mackay (LM), modified Lund–Kennedy (MLK) scores....