A5021806113- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Neural dynamics and brain function
- COVID-19 and Mental Health
- Functional Brain Connectivity Studies
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Advanced Memory and Neural Computing
- Osteoarthritis Treatment and Mechanisms
- Tissue Engineering and Regenerative Medicine
- Mental Health Research Topics
- Intracerebral and Subarachnoid Hemorrhage Research
- Tracheal and airway disorders
- EEG and Brain-Computer Interfaces
- Mental Health Treatment and Access
- Acupuncture Treatment Research Studies
- Lipid metabolism and disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Retinal and Macular Surgery
- Ophthalmology and Visual Impairment Studies
- Retinopathy of Prematurity Studies
- Chemical synthesis and alkaloids
- Traditional Chinese Medicine Studies
- Gout, Hyperuricemia, Uric Acid
Peking University
2021-2025
Southern Medical University
2025
Aerospace Center Hospital
2025
Peking University Sixth Hospital
2021-2024
Sun Yat-sen University
2014-2024
Soochow University
2021-2024
First Affiliated Hospital of Soochow University
2021-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2024
Case Western Reserve University
2002-2024
Wuhan University
2024
Abstract Mitochondrial dysfunction contributes to the development of secondary brain injury (SBI) following intracerebral hemorrhage (ICH) and represents a promising therapeutic target. Celastrol, primary active component Tripterygium wilfordii , is natural product that exhibits mitochondrial neuronal protection in various cell types. This study aims investigate neuroprotective effects celastrol against ICH‐induced SBI explore its underlying mechanisms. Celastrol improves neurobehavioral...
Mild cognitive impairment (MCI) is a heterogeneous syndrome characterized by on neurocognitive tests but accompanied relatively intact daily activities. Due to high variation and no objective methods for diagnosing treating MCI, guidance neuroimaging needed. The study has explored the biomarkers using support vector machine (SVM) method predict MCI.In total, 53 patients with MCI 68 healthy controls were involved in scanning resting-state functional magnetic resonance imaging (rs-fMRI)....
Suicide is positively associated with a range of psychological risk factors such as family function and depression. However, it remains unclear if depression mediates the association between suicide in Chinese adolescents. We enrolled 14263 students from Shenzhen Polytechnic College, China. Family function, were assessed these by self-report measures, respectively. With path analysis logistic regression, mediating role was analyzed. In this study, detection rate suicide-related behaviors...
The Asian Summer Monsoon provides critical water source to over a billion people. However, there is mounting evidence regarding how precipitation associated with the varies spatially and temporally, prompting further exploration of underlying mechanisms. Here, we reconstruct ~2900-year summer record through grain-size clay analyses core M5-8 retrieved from Bohai Sea in China. Our records indicate that warm (cold) phase Atlantic Multidecadal Variability significantly increases (decreases)...
Heart failure (HF) in elderly patients with concurrent hypotension presents a therapeutic challenge due to limited standard HF therapies' applicability. Recombinant human brain natriuretic peptide (rhBNP) and vasoactive medications have shown potential management, but their combined efficacy remains understudied. This retrospective cohort study included who received rhBNP alone (Group A, n = 68), dobutamine B, 74), or dopamine C, 71). Biomarker responses, cardiac function, adverse events,...
Neuromyelitis optica spectrum disorder (NMOSD) can coexist with non-organ-specific or organ-specific autoimmune diseases. The aim of this study was to investigate and compare the features between NMOSD without diseases, diseases.One hundred fifty five patients diseases (n = 115) 40) were enrolled. divided by clinical, laboratory magnetic resonance imaging two groups assessed.Motor deficit less frequent in (p 0.024). Cerebrospinal fluid white blood cell protein, serum C-reactive protein...
Background:Eurycoma longifolia is a tropical medicinal plant belonging to Simaroubaceae distributed in South East Asia. The stems are traditionally used for the treatment of sexual insufficiency, fever, hypertension, and malaria. Furthermore, it has antidiabetic anticancer activities. Recently, been reported reduce uric acid, but mechanism unclear. Hypothesis/Purpose: aim this study explore effect E. stem 70% ethanol extract (EL) its active compounds on acid excretion. Study Design Methods:...
The Coronavirus has infected up to 900 million people as of 11 Jan 2023 in China Mainland, which is more than 60% the population. sudden and unprecedented nature pandemic resulted a range psychosomatic issues among These can manifest variety ways it important address these they have serious consequences for individuals' mental physical health. lifting lockdown measures presents an opportunity provide support those who been affected.
Abstract The influences of pore sizes and surface modifications on biomechanical properties biocompatibility (BC) porous tracheal scaffolds (PTSs) fabricated by polycaprolactone (PCL) using 3D printing technology. grafts were surface‐modified through hydrolysis, amination, nanocrystallization treatment. the modified characterized energy dispersive spectroscopy (EDS) scanning electron microscopy (SEM). materials cocultured with bone marrow mesenchymal stem cells (BMSCs). effect different cell...
To generate novel rabbit models with a large-fragment deletion of either LDL receptor (LDLR) and/or apolipoprotein (apoE) genes for the study hyperlipidemic and atherosclerosis. CRISPR/Cas9 system directed by multiple sgRNAs was used in embryos to edit their LDLR apoE genes. The founder rabbits were sequenced, plasma lipids lipoprotein profiles on normal chow diet analyzed, western blotting also performed evaluate expression apolipoprotein. Sudan IV HE staining aortic confirm formation Six...
Objective There is no objective method to diagnose major depressive disorder (MDD). This study explored the neuroimaging biomarkers using support vector machine (SVM) for diagnosis of MDD. Methods 52 MDD patients and 45 healthy controls (HCs) were involved in resting-state functional magnetic resonance imaging (rs-fMRI) scanning. Imaging data analyzed with regional homogeneity (ReHo) SVM methods. Results Compared HCs, showed increased ReHo left anterior cingulum cortex (ACC) decreased...
Previous studies have revealed the frontoparietal network (FPN) plays a key role in imaging pathophysiology of bipolar disorder (BD). However, homogeneity (NH) FPN among mania (BipM), remitted (rBD), and healthy controls (HCs) remains unknown. The present study aimed to explore whether NH within can be used as an biomarker differentiate BipM from rBD predict treatment efficacy for patients with BipM.Sixty-six BD (38 28 rBD) 60 HCs participated resting-state functional magnetic resonance...
Objectives. It is a high risk for adolescents with first-episode major depressive disorder (MDD) to commit suicide. However, few studies reported the effect of modified electroconvulsive therapy (MECT) in antipsychotic-naive MDD adolescents. Methods. The study explores alternations regional homogeneity treat disorder. 72 patients were recruited from Tianyou Hospital Affiliated Wuhan University Science and Technology October 2017 May 2020, 65 completed trial. Results. Before MECT treatment,...