A5007069912- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Fullerene Chemistry and Applications
- Polymer Nanocomposite Synthesis and Irradiation
- Nanoparticles: synthesis and applications
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Spaceflight effects on biology
- Plant biochemistry and biosynthesis
- Gold and Silver Nanoparticles Synthesis and Applications
- Carbon dioxide utilization in catalysis
- Laser-Ablation Synthesis of Nanoparticles
- Mass Spectrometry Techniques and Applications
- Coenzyme Q10 studies and effects
- Radiation Therapy and Dosimetry
- Ferrocene Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- Zeolite Catalysis and Synthesis
- Anesthesia and Neurotoxicity Research
- Boron and Carbon Nanomaterials Research
- Diamond and Carbon-based Materials Research
- Natural product bioactivities and synthesis
- RNA and protein synthesis mechanisms
- Sesquiterpenes and Asteraceae Studies
- Peptidase Inhibition and Analysis
University of Gdańsk
2019-2024
University of Pennsylvania
2021-2023
Gdańsk Medical University
2018-2022
Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major types, and provides perspectives for future development. therapeutics
Lipid nanoparticles (LNPs) play a crucial role in delivering messenger RNA (mRNA) therapeutics for clinical applications, including COVID-19 mRNA vaccines. While can be chemically modified to become immune-silent and increase protein expression, LNPs still trigger innate immune responses cause inflammation-related adverse effects. Inflammation turn suppress translation reduce the therapeutic effect. Dexamethasone (Dex) is widely used anti-inflammatory corticosteroid medication that...
Evasion of apoptosis is a hallmark cancer, attributed in part to overexpression the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2). In variety cancer types, including lymphoma, Bcl-2 overexpressed. Therapeutic targeting has demonstrated efficacy clinic and subject extensive clinical testing combination with chemotherapy. Therefore, development co-delivery systems for agents, such as small interfering RNA (siRNA), chemotherapeutics, doxorubicin (DOX), holds promise enabling therapies. Lipid...
Among metal-based nanoparticles, silver nanoparticles (AgNPs) are particularly appealing because of their stability, functionality, and documented antimicrobial properties. AgNPs also offer the possibility different surface modifications. In this work, we functionalized with thiobarbituric acid or 11-mercaptoundecanoic residues to improve nanoparticles’ biological activities. Subsequently, assessed physicochemical properties newly synthesized using a wide range biophysical methodologies,...
C60 fullerene as a potent free radical scavenger and antioxidant could be beneficial means for neurodegenerative disease prevention or cure. The aim of the study was to define effects administration on mitochondrial dysfunction oxidative stress disorders in 3-nitropropionic acid (3-NPA)-induced rat model Huntington’s disease. Animals received 3-NPA (30 mg/kg i.p.) once day 3 consecutive days. applied at dose 0.5 body weight, i.p. daily over 5 days before (C60 pre-treatment) after exposure...
5-trifluoromethanesulfonyl-uracil (OTfU), a recently proposed radiosensitizer, is decomposed in the gas-phase by attachment of low-energy electrons. OTfU derivative uracil with triflate (OTf) group at C5-position, which substantially increases its ability to undergo effective electron-induced dissociation. We report rich assortment fragments formed upon dissociative electron (DEA), mostly simple bond cleavages (e.g., dehydrogenation or formation OTf-). The most favorable DEA channel...
Abstract Conjugating an anticancer drug of high biological efficacy but large cytotoxicity with a “transporting” molecule low toxicity constitutes valuable approach to design safe delivery system. In the present study, doxorubicin (DOX) cardiotoxicity was chemically conjugated C 60 -fullerene. The synthesized molecule, fullerene-doxorubicin conjugate (Ful-DOX), characterized using 1 H NMR and MALDI TOF mass spectrometry. absorption fluorescence spectra dynamic light scattering were recorded...
Being a scavenger of free radicals, C60 fullerenes can influence on the physiological processes in skeletal muscles, however, effect such carbon nanoparticles muscle contractility under acute inflammation remains unclear. Thus, aim study was to reveal fullerene aqueous solution (C60FAS) contractile properties inflammatory pain.To induce 2.5% formalin injected into rat triceps surae (TS) muscle. High-frequency electrical stimulation has been used tetanic contraction. A linear motor...
Matrix metalloproteinases (MMPs) are extracellular matrix degradation factors, promoting cancer progression. Hence, they could provide an enzyme-assisted delivery of doxorubicin (DOX) in treatment. In the current study, intercalation process DOX and tetrapeptide–DOX, product MMPs’ cleavage carrier-linked DOX, into dsDNA was investigated using stationary time-resolved fluorescence spectroscopy, UV-Vis spectrophotometry isothermal titration calorimetry (ITC). The molecular dynamics (MD)...
Doxorubicin, a member of the anthracycline family, is common anticancer agent often used as first line treatment for wide spectrum cancers. Doxorubicin-based chemotherapy, although effective, associated with serious side effects, such irreversible cardiotoxicity or nephrotoxicity. Those life-threatening adverse risks, responsible elongation patients' recuperation period and increasing medical expenses, have prompted need creating novel safer drug delivery systems. Among many proposed...
Breast cancer is one of cancer's most deadly varieties. Its variability makes the development personalized therapies very difficult. Therefore, improvement classic chemotherapy still important challenges research. We addressed this issue applying nanotechnology to verify influence silver nanoparticles (AgNPs) on doxorubicin (DOX) anticancer activity and assess if size AgNPs affects their interactions with DOX. employed a broad spectrum biophysical methods, characterizing 5 50 nm DOX using...
Abstract The fundamental aspects related to the mechanisms of action C 60 fullerene nanoparticles on level central nervous system in different experimental conditions are still unclear. Electrophysiological investigation and immunohistochemical techniques c-fos expression were combined determine which neural elements within lumbar segments nucleus amygdala (CeA) activated under skeletal muscle fatigue development with prior application fullerenes (dissolved dimethyl sulfoxide distilled...