A5000392640- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Fullerene Chemistry and Applications
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Graphene and Nanomaterials Applications
- Telomeres, Telomerase, and Senescence
- Polymer Nanocomposite Synthesis and Irradiation
- Nutrition and Health in Aging
- Nanoparticle-Based Drug Delivery
- Congenital heart defects research
- Metal complexes synthesis and properties
- Nanoparticles: synthesis and applications
- Metabolism, Diabetes, and Cancer
- Genetics and Neurodevelopmental Disorders
- DNA and Nucleic Acid Chemistry
- Metabolomics and Mass Spectrometry Studies
- Electron Spin Resonance Studies
- Diamond and Carbon-based Materials Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- NF-κB Signaling Pathways
- Gold and Silver Nanoparticles Synthesis and Applications
- Antibiotics Pharmacokinetics and Efficacy
- Carbon Nanotubes in Composites
Oklahoma Medical Research Foundation
2021-2024
Université Grenoble Alpes
2024
University of Gdańsk
2015-2023
Gdańsk Medical University
2016-2022
Abstract The goal of this study was to test the role cellular senescence plays in increased inflammation, chronic liver disease, and hepatocellular carcinoma seen mice null for Cu/Zn‐Superoxide dismutase (Sod1KO). To inhibit senescence, wildtype (WT) Sod1KO were given senolytics, dasatinib, quercetin (D + Q) at 6 months age when begin exhibiting signs accelerated aging. Seven D Q treatment reduced expression p16 livers WT levels several senescence‐associated secretory phenotype factors...
Abstract The skeletal muscle research field generally accepts that nuclei in fibers (ie, myonuclei) are post-mitotic and unable to proliferate. Because our deuterium oxide (D2O) labeling studies showed DNA synthesis tissue, we hypothesized resident myonuclei can replicate vivo. To test this hypothesis, used a mouse model temporally labeled with GFP followed by D2O during normal cage activity, functional overload, satellite cell ablation. During observed enrichment into myonuclear 7 out of...
Abstract Background Skeletal muscle mass and strength diminish during periods of disuse but recover upon return to weight bearing in healthy adults are incomplete old muscle. Efforts improve recovery older individuals commonly aim at increasing myofibrillar protein synthesis via mammalian target rapamycin (mTOR) stimulation despite evidence demonstrating that has chronically elevated levels complex 1 (mTORC1) activity. We hypothesized is higher than adult muscle, which contributes a...
Among metal-based nanoparticles, silver nanoparticles (AgNPs) are particularly appealing because of their stability, functionality, and documented antimicrobial properties. AgNPs also offer the possibility different surface modifications. In this work, we functionalized with thiobarbituric acid or 11-mercaptoundecanoic residues to improve nanoparticles’ biological activities. Subsequently, assessed physicochemical properties newly synthesized using a wide range biophysical methodologies,...
C60 fullerene as a potent free radical scavenger and antioxidant could be beneficial means for neurodegenerative disease prevention or cure. The aim of the study was to define effects administration on mitochondrial dysfunction oxidative stress disorders in 3-nitropropionic acid (3-NPA)-induced rat model Huntington’s disease. Animals received 3-NPA (30 mg/kg i.p.) once day 3 consecutive days. applied at dose 0.5 body weight, i.p. daily over 5 days before (C60 pre-treatment) after exposure...
Using a multiomics approach, we show that 17α-E2 alleviates HFD-induced metabolic detriments in skeletal muscle by altering bioactive lipid intermediates, inflammatory cytokines, and the abundance of proteins related to lipolysis contraction. The positive effects occur both sexes but differ their outcome.
With the rapid and continuous emergence of antimicrobial resistance, bacterial infections became a significant global healthcare concern. One proposed strategies to combat multidrug-resistant pathogens is use additional compounds, such as natural biologically active substances, adjuvants for existing antibiotics. In this study, we investigated potential caffeine, widely consumed alkaloid, modulate antibacterial effects antibiotics commonly used in clinical practice. We disc diffusion assay...
Staphylococcus aureus is a human pathogen responsible for many antibiotic-resistant infections, instance burn wound which pose threat to life. Exploring possible synergy between various antimicrobial agents, like nanoparticles and plant natural products, may provide new weapons combat antibiotic resistant pathogens. The objective of this study was examine the potential silver (AgNPs) enhance activity selected naphthoquinones (NQs): plumbagin (PL), ramentaceone (RAM), droserone (DR),...
Abstract Background Ageing and cachexia cause a loss of muscle mass over time, indicating that protein breakdown exceeds synthesis. Deuterium oxide (D 2 O) is used for studies turnover because the advantages long‐term labelling, but these methods introduce considerations have been largely overlooked when studying conditions gain or loss. The purpose this study was to demonstrate importance accounting change in mass, non‐steady state, during D O labelling while also exploring contribution...
Abstract Targeting chondrocyte dynamics is a strategy for slowing osteoarthritis progression during aging. We describe stable-isotope method using in vivo deuterium oxide labeling and mass spectrometry to measure protein concentration, half-life, cell proliferation, ribosomal biogenesis single sample of murine articular cartilage. hypothesized that 60-d period would capture age-related declines cartilage matrix content, synthesis rates, cellular proliferation. Knee was harvested the...
One of the greatest challenges modern medicine is to find cheaper and easier ways produce transporters for biologically active substances, which will provide selective efficient drug delivery target cells, while causing low toxicity towards healthy cells. Currently, metal-based nanoparticles are considered a successful viable solution this problem. In work, we propose use novel synthesis method platinum (PtNPs) connected with their precise biophysical characterization assessment potential...
The rationale for the use of metformin as a treatment to slow aging was largely based on data collected from metabolically unhealthy individuals. For healthspan extension will also be used in periods good health. To understand potential context specificity skeletal muscle, we rat model (high-capacity runner/low-capacity runner [HCR/LCR]) with divide intrinsic aerobic capacity. Outcomes differed baseline mitochondrial function, oxidative capacity muscle (gastroc vs soleus), and population...
By means of small‐angle neutron scattering and ames mutagenicity test it was shown that C 60 fullerene may act as an interceptor the antibiotic doxorubicin by formation a hetero‐complex with this drug. This result has been predicted based on previously developed model chemico‐biological interaction between DNA‐binding drugs aromatic molecules.
Being a scavenger of free radicals, C60 fullerenes can influence on the physiological processes in skeletal muscles, however, effect such carbon nanoparticles muscle contractility under acute inflammation remains unclear. Thus, aim study was to reveal fullerene aqueous solution (C60FAS) contractile properties inflammatory pain.To induce 2.5% formalin injected into rat triceps surae (TS) muscle. High-frequency electrical stimulation has been used tetanic contraction. A linear motor...
Cancer survivors are more susceptible to pathologies such as hypertension, liver disease, depression, and coronary artery disease when compared with individuals who have never been diagnosed cancer. Therefore, it is important understand how tumor burden negatively impacts nontumor-bearing tissues that may impact future susceptibility. We hypothesized the energetic costs of a would compromise proteostatic maintenance in other tissues. purpose this study was determine if changes protein...
Abstract Dietary sulfur amino acid restriction (SAAR) protects against diet-induced obesity, extends healthspan, and coincides with an overall reduction in hepatic protein synthesis. To explore the underpinnings of SAAR-induced slowed growth its impact on liver metabolism proteostasis, we resolved changes mRNA abundances compared synthesis rates individual proteins. achieve this, adult male mice were provided deuterium-labeled drinking water while freely consuming either a regular-fat or...
Doxorubicin, a member of the anthracycline family, is common anticancer agent often used as first line treatment for wide spectrum cancers. Doxorubicin-based chemotherapy, although effective, associated with serious side effects, such irreversible cardiotoxicity or nephrotoxicity. Those life-threatening adverse risks, responsible elongation patients' recuperation period and increasing medical expenses, have prompted need creating novel safer drug delivery systems. Among many proposed...