A5014312942- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Estrogen and related hormone effects
- Menopause: Health Impacts and Treatments
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Genetics, Aging, and Longevity in Model Organisms
- Adipokines, Inflammation, and Metabolic Diseases
- Hormonal and reproductive studies
- Lipid Membrane Structure and Behavior
- Birth, Development, and Health
- Hormonal Regulation and Hypertension
- Nutrition, Genetics, and Disease
- Macrophage Migration Inhibitory Factor
- Sex and Gender in Healthcare
- Calpain Protease Function and Regulation
- Bioactive natural compounds
- Insect Pheromone Research and Control
- Endometriosis Research and Treatment
- Peroxisome Proliferator-Activated Receptors
- FOXO transcription factor regulation
- Sphingolipid Metabolism and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
University of Arizona
2022-2024
University of Oklahoma Health Sciences Center
2013-2023
University of Oklahoma
2011-2022
Oklahoma Medical Research Foundation
2021
Dean McGee Eye Institute
2013
Metabolic dysfunction underlies several chronic diseases, many of which are exacerbated by obesity. Dietary interventions can reverse metabolic declines and slow aging, although compliance issues remain paramount. 17α-estradiol treatment improves parameters slows aging in male mice. The mechanisms elicits these benefits unresolved. Herein, we show that similar genomic binding transcriptional activation through estrogen receptor α (ERα) to 17β-estradiol. In addition, the ablation ERα...
Botanical compounds have been widely used throughout history as cures for various diseases and ailments. Many of these exhibit strong antioxidative, anti-inflammatory, antiapoptotic properties. These are also common damaging mechanisms apparent in several ocular diseases, including age-related macular degeneration (AMD), glaucoma, diabetic retinopathy, cataract, retinitis pigmentosa. In recent years, there many epidemiological clinical studies that demonstrated the beneficial effects...
Using a multiomics approach, we show that 17α-E2 alleviates HFD-induced metabolic detriments in skeletal muscle by altering bioactive lipid intermediates, inflammatory cytokines, and the abundance of proteins related to lipolysis contraction. The positive effects occur both sexes but differ their outcome.
Abstract 17α-Estradiol (17α-E2) is a “non-feminizing” estrogen that extends life span in male, but not female, mice. We recently reported 17α-E2 had robust beneficial effects on metabolic and inflammatory parameters aged male However, it remains unclear if also delays other “hallmarks” of aging, particularly maintaining proteostasis. Here, we used isotope labeling methods older mice to examine proteostatic mechanisms. compared weight-matched mild calorie restricted (CR) treated with the...
Menopause is a natural physiological process in older women that associated with reduced estrogen production and results increased risk for obesity, diabetes, osteoporosis. 17α-estradiol (17α-E2) treatment males, but not females, reverses several metabolic conditions advancing age, highlighting sexually dimorphic actions on age-related pathologies. In this study we sought to determine if 17α-E2 could prevent ovariectomy (OVX)-mediated detriments adiposity bone parameters females....
Abstract Metabolic dysfunction underlies several chronic diseases. Dietary interventions can reverse metabolic declines and slow aging but remaining compliant is difficult. 17α-estradiol (17α-E2) treatment improves parameters slows in male mice without inducing significant feminization. We recently reported that estrogen receptor α required for the majority of 17α-E2-mediated benefits mice, 17α-E2 also attenuates fibrogenesis liver, which regulated by β (ERβ)-expressing hepatic stellate...
Nuclear receptor Peroxisome Proliferator-Activated Receptor γ (PPARγ) is a promising target for the treatment of type 2 diabetes. The antidiabetic drug thiazolidinediones (TZDs) are potent insulin sensitizers as full agonists PPARγ, but cause unwanted side effects. Recent discoveries have shown that TZDs improve sensitivity by blocking PPARγ phosphorylation at S273, which decouples agonism-associated ligands act through blockage lack agonist activity would be expected to without...
Estrogen signaling is protective against chronic liver diseases, although men and a subset of women are contraindicated for treatment with 17β-estradiol (17β-E2) or combination hormone replacement therapies. We sought to determine if 17α-estradiol (17α-E2), naturally occurring diastereomer 17β-E2, could attenuate fibrosis. evaluated the effects 17α-E2 on collagen synthesis degradation rates using tracer-based labeling approaches in male mice subjected carbon tetrachloride (CCl
A healthy heart adapts to changes in nutrient availability and energy demands. In metabolic diseases like type 2 diabetes (T2D), increased reliance on fatty acids for production contributes mitochondrial dysfunction cardiomyopathy. principal regulator of cardiac metabolism is 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2), which a central driver glycolysis. We hypothesized that increasing PFK-2 activity could mitigate induced by high-fat diet (HFD). Wild (WT) cardiac-specific...
Nutritional manipulations early in life have been shown to influence growth rate and elicit long lasting effects which turn has found impact lifespan. Therefore, we studied the long-term of pre-weaning dietary restriction implemented by litter expansion (4, 6, 8, 10, 12 pups per dam: LS4, LS6, LS8, LS10, LS12) on male female C57BL/6J mice. After weaning, these mice were fed ad libitum a commercial lab chow for 15-month duration study. The from large size (LS12) significantly leaner had...
Metabolic dysfunction underlies several chronic diseases. Dietary interventions can reverse metabolic declines and slow aging but remaining compliant is difficult. 17α-estradiol (17α-E2) treatment improves parameters slows in male mice without inducing significant feminization. We recently reported that estrogen receptor α required for the majority of 17α-E2-mediated benefits mice, 17α-E2 also attenuates fibrogenesis liver, which regulated by β (ERβ)-expressing hepatic stellate cells (HSC)....
To meet the increasing need for low-cost, compact imaging technology with cellular resolution, we have developed a microLED-based structured light sheet microscope three-dimensional ex vivo and in of biological tissue multiple modalities. All illumination structure is generated directly at microLED panel—which serves as source—so scanning modulation completely digital, yielding system that simpler less prone to error than previously reported methods. Volumetric images optical sectioning are...
ABSTRACT Metabolic dysfunction underlies several chronic diseases, many of which are exacerbated by obesity. Dietary interventions can reverse metabolic declines and slow aging, although compliance issues remain paramount. 17α-estradiol treatment improves parameters slows aging in male mice. The mechanisms elicits these benefits unresolved. Herein, we show that similar genomic binding transcriptional activation through estrogen receptor α (ERα) to 17β-estradiol. In addition, the ablation ERα...
ABSTRACT Background Estrogen signaling is protective against chronic liver diseases, although men and a subset of women are contraindicated for treatment with 17β-estradiol (17β-E2) or combination hormone replacement therapies. We sought to determine if 17α-estradiol (17α-E2), naturally-occurring diastereomer 17β-E2, could attenuate fibrosis. Methods evaluated the effects 17α-E2 on collagen synthesis degradation rates using tracer-based labeling approaches in male mice subjected carbon...
Abstract Skeletal muscle has a central role in maintaining metabolic homeostasis. 17α-estradiol (17α-E2), naturally-occurring non-feminizing diastereomer of 17β-estradiol that demonstrates efficacy for improving outcomes male, but not female, mice. Despite several lines evidence showing 17α-E2 treatment improves parameters middle-aged obese and old male mice through effects brain, liver, white adipose tissue little is known about how alters skeletal metabolism, what this may play mitigating...
Abstract Nutritional manipulations early in life have been shown to influence growth rate and elicit long lasting effects which turn has found impact lifespan. Therefore, we studied the long-term of pre-weaning dietary restriction implemented by litter expansion (4, 6, 8, 10, 12 pups per dam: LS4, LS6, LS8, LS10, LS12) on male female C57BL/6 mice. After weaning, these mice were fed ad libitum a commercial lab chow for 15-month duration study. The from large sizes (LS12) significantly leaner...