A5100368245- Colorectal Cancer Treatments and Studies
- Congenital Heart Disease Studies
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Cardiovascular Disease and Adiposity
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Ubiquitin and proteasome pathways
- Congenital Anomalies and Fetal Surgery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Microfluidic and Bio-sensing Technologies
- Viral Infectious Diseases and Gene Expression in Insects
- Colorectal and Anal Carcinomas
- Nutrition and Health in Aging
- Microscopic Colitis
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
Yale University
2023-2024
Shanghai Jiao Tong University
2015-2024
Shanghai Children's Medical Center
2013-2024
Fujian Medical University
2024
University of Oklahoma Health Sciences Center
2014-2023
The University of Texas MD Anderson Cancer Center
2018-2023
Chengdu University of Information Technology
2023
Xinjiang Production and Construction Corps
2022
University of Oklahoma
2020-2022
Oklahoma State University Oklahoma City
2022
<h3>Background</h3> Immune checkpoint inhibitors (ICPI) are efficacious treatments for advanced malignancies but can result in immune mediated diarrhea and colitis (IDC). Currently, the guidelines treatment of IDC depend only on clinical symptoms. Endoscopic histologic features such adverse events not well studied a manner that help to gauge plans. We aimed characterize endoscopic assess their association with outcomes. <h3>Methods</h3> Our study included patients who had undergone endoscopy...
<h3>Background</h3> Immune-mediated diarrhea and colitis (IMDC) can limit immune checkpoint inhibitors (ICIs) treatment, which is efficacious for advanced malignancies. Steroids infliximab are commonly used to treat it. These agents induce systemic immunosuppression, with its associated morbidity. We assessed clinical outcomes of vedolizumab as an alternative treatment IMDC. <h3>Methods</h3> analyzed a retrospective case series adults who had IMDC refractory steroids and/or received from...
Background & AimsPancreatic cancer has the highest prevalence of cancer-associated cachexia among all cancers. ZIP4 promotes pancreatic progression by regulating oncogenic miR-373, and perturbation circular RNAs (circRNAs) is associated with aggressiveness. This study aimed to identify circRNAs involved in ZIP4/miR-373–driven growth decipher underlying mechanism.MethodsDifferentially expressed potential targets microRNA were identified through silico analysis. The RNA interactions determined...
With limited treatment options, cachexia remains a major challenge for patients with cancer. Characterizing the interplay between tumor cells and immune microenvironment may help identify potential therapeutic targets cancer cachexia. Herein, we investigate critical role of macrophages in potentiating pancreatic induced muscle wasting via promoting TWEAK (TNF-like weak inducer apoptosis) secretion from tumor. Specifically, depletion reverses degradation by cells. Macrophages induce...
Background: Immune checkpoint inhibitors (ICIs) have demonstrated effectiveness in treating many malignancies. Gastrointestinal (GI) adverse events are commonly reported; however, few reports describe upper GI tract toxic effects. We aimed to clinical features of injury related ICI.Methods: studied consecutive patients who received ICIs between April 2011 and March 2018 developed symptoms requiring esophagogastroduodenoscopy (EGD).Results: Sixty ICI initiation 6 months after the last...
BackgroundN6-methyladenosine (m6A) is the most abundant mRNA modification. Whether m6A regulators can determine tumor aggressiveness and risk of immune evasion in pancreatic ductal adenocarcinoma (PDAC) remains unknown.MethodsAn integrated model named "m6Ascore" constructed based on RNA-seq data PDAC. Association m6Ascore overall survival validated across several different datasets. Overlaps established molecular classifications PDAC examined. Immune infiltration, enriched pathways, somatic...
Abstract The goal of this study was to test the role cellular senescence plays in increased inflammation, chronic liver disease, and hepatocellular carcinoma seen mice null for Cu/Zn‐Superoxide dismutase (Sod1KO). To inhibit senescence, wildtype (WT) Sod1KO were given senolytics, dasatinib, quercetin (D + Q) at 6 months age when begin exhibiting signs accelerated aging. Seven D Q treatment reduced expression p16 livers WT levels several senescence‐associated secretory phenotype factors...
<h3>Background</h3> Immune checkpoint inhibitors (ICPIs), used to treat different advanced malignancies, are associated with a wide range of immune-related adverse reactions (irAEs) that deserve close monitoring patients. Gastrointestinal and hepatotoxicity may occur, which warrant careful evaluation confirm the etiology attribution ICPIs as these events could affect future management. <h3>Case presentation</h3> We describe case patient with prostate adenocarcinoma, treated dual...
Background: Cachexia is a systemic disease manifested with muscle atrophy and appetite loss, especially in patients pancreatic cancer. Emerging evidence showed that cachexia an inflammation-associated disease. But the role of tumor immune microenvironment remains elusive. ZIP4, zinc transporter, plays critical promoting cancer cachexia. We aimed to study how ZIP4 promotes via interacting microenvironment. Methods: evaluated association between several major cell types tissue Genetically...
Digital orientation has attracted significant attention from policymakers and researchers due to its potential drive innovation success. While prior research largely examined the impact of digital on specific types a static lens, holistic dynamic perspective relationship with firms’ overall performance remains limited. Drawing capabilities theory, this study aims bridge gap by developing moderated mediation model that incorporates mediating role moderating effect environmental dynamism in...
ABSTRACT Baculovirus (BV) is a promising gene therapy vector and typically requires readministration because BV mediates transient expression. However, how the prime-boost regimen triggers BV-specific adaptive responses their impacts on readministration, transgene expression, therapeutic/vaccine efficacy remain unknown. Here we unraveled that injection into BALB/c mice induced production of antibodies, including IgG1 IgG2a, which could neutralize by antagonizing envelope protein gp64 impede...
In neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), chronic activation of microglia contributes to disease progression. Activated produce cytokines, chemokines, and other factors that normally serve clear infection or damaged tissue either directly through the recruitment immune cells. The molecular program driving this phenotype is classically linked transcription factor NF-κB characterized by upregulation proinflammatory IL-1β, TNF-α, IL-6. Here, we investigated role...
Organoids mimic the physiologic and pathologic events of organs. However, no consensus on esophageal organoid (EO) culture methods has been reached. Moreover, models reproducing squamous cell carcinoma (ESCC) initiation have unavailable. Herein, we sought to develop an minimum essential medium (E-MEOM) for culturing murine EOs establishing early ESCC model. We formulated E-MEOM grow from a single with clonal expansion, maintenance, passage. found that cultured in were equivalent epithelium...
Nanoparticles are popular tools utilized to selectively deliver drugs and contrast agents for identification treatment of disease. To determine the usefulness translational potential mesoporous silica nanoparticles (MSNs), further evaluations toxicity required. MSNs among most nano-delivery systems due ease synthesis, pore structure, functionalization. This study aims elucidate as a result intravenous injection 25 nm coated with chitosan (C) or polyethylene glycol (PEG) in mice. Following...
Therapeutic reduction of hydrophobic bile acids exposure is considered beneficial in cholestasis. The Cyp2c70 KO mice lack hydrophilic muricholic and have a human-like acid pool resulting hepatobiliary injury. This study investigates if combining an apical sodium-dependent transporter inhibitor GSK2330672 (GSK) fibroblast growth factor-15 (FGF15) overexpression, via simultaneous inhibition synthesis gut uptake, achieves enhanced therapeutic efficacy alleviating injury mice. effects GSK,...
Posttranscriptional gene regulation is governed by a network of RNA-binding proteins (RBPs) that interact with regulatory elements in the mRNA to modulate multiple molecular processes, including splicing, RNA transport, stability, and translation. Mounting evidence indicates there hierarchy within this whereby certain RBPs cross-regulate other coordinate expression. HuR, an protein we linked previously aberrant VEGF metabolism models SOD1-associated amyotrophic lateral sclerosis, has been...