A5042592485- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Invertebrate Immune Response Mechanisms
- Health Literacy and Information Accessibility
- Hippo pathway signaling and YAP/TAZ
- Cancer-related molecular mechanisms research
- Cellular Mechanics and Interactions
- Cancer-related gene regulation
- Renal and related cancers
- DNA Repair Mechanisms
- FOXO transcription factor regulation
- Genetic factors in colorectal cancer
- Pain Mechanisms and Treatments
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Carcinogens and Genotoxicity Assessment
- Escherichia coli research studies
- Vibrio bacteria research studies
- Diet and metabolism studies
- CRISPR and Genetic Engineering
- Pregnancy-related medical research
- Congenital Anomalies and Fetal Surgery
- Silk-based biomaterials and applications
- Adenosine and Purinergic Signaling
Gachon University
2023-2025
The University of Texas MD Anderson Cancer Center
2016-2024
Jeonnam Bioindustry Foundation
2023
Yonsei University
2008-2020
Seoul National University Dental Hospital
2019
Daejeon Sun Hospital
2017
Geriatric Research Education and Clinical Center
2005
Saint Louis University
2005
Ajou University
2001
Abstract Despite the implication of Wnt signalling in radioresistance, underlying mechanisms are unknown. Here we find that high is associated with radioresistance colorectal cancer (CRC) cells and intestinal stem (ISCs). We LIG4 , a DNA ligase double-strand break repair, direct target β-catenin. enhances non-homologous end-joining repair CRC, which mediated by transactivated During radiation-induced regeneration, mainly expressed crypts conditionally upregulated ISCs, accompanied...
Background and Aims How Wnt signaling is orchestrated in liver regeneration tumorigenesis remains elusive. Recently, we identified transmembrane protein 9 (TMEM9) as a amplifier. Approach Results TMEM9 facilitates v‐ATPase assembly for vesicular acidification lysosomal degradation. highly expressed regenerating hepatocellular carcinoma (HCC) cells. expression enriched the hepatocytes around central vein acutely induced by injury. In mice, Tmem9 knockout impairs hepatic with aberrantly...
The DREAM complex orchestrates cell quiescence and the cycle. However, how is deregulated in cancer remains elusive. Here, we report that PAF (PCLAF/KIAA0101) drives exit to promote lung tumorigenesis by remodeling complex. highly expressed adenocarcinoma (LUAD) associated with poor prognosis. Importantly, Paf knockout markedly suppressed LUAD development mouse models. depletion induced growth arrest. required for global expression of cell-cycle genes controlled repressive Mechanistically,...
Fine control of stem cell maintenance and activation is crucial for tissue homeostasis regeneration. However, the mechanism quiescence exit Tert+ intestinal cells (ISCs) remains unknown. Employing a Tert knockin (TertTCE/+) mouse model, we found that are long-term label-retaining self-renewing cells, which partially distinguished from previously identified +4 ISCs. become mitotic upon irradiation (IR) injury. Conditional ablation impairs IR-induced regeneration but not homeostasis. Upon IR...
Organoids mimic the physiologic and pathologic events of organs. However, no consensus on esophageal organoid (EO) culture methods has been reached. Moreover, models reproducing squamous cell carcinoma (ESCC) initiation have unavailable. Herein, we sought to develop an minimum essential medium (E-MEOM) for culturing murine EOs establishing early ESCC model. We formulated E-MEOM grow from a single with clonal expansion, maintenance, passage. found that cultured in were equivalent epithelium...
The mechanism underlying immune system recognition of different types pathogens has been extensively studied over the past few decades; however, by which healthy self-tissue evades an attack its own is less well-understood. Here, we established autoimmune model melanotic mass formation in Drosophila genetically disrupting basement membrane. We found that membrane endows otherwise susceptible target tissues with self-tolerance prevents autoimmunity, and further demonstrated laminin a key...
Rho‐family small GTPases regulate epithelial cell sheet migration by organizing actin and myosin during wound healing. Here, we report that Pak3, but not Pak1, is a downstream target protein for Rac1 in closure of the Drosophila larval epidermis. Pak3‐deficient larvae failed to close hole this defect was rescued Pak1 expression, indicating differential functions two proteins. Pak3 localized margin, which selectively required Rac1. showed severe defects actin‐myosin organization at margin...
Cell plasticity, changes in cell fate, is crucial for tissue regeneration. In the lung, failure of regeneration leads to diseases, including fibrosis. However, mechanisms governing alveolar plasticity during lung repair remain elusive. We previously showed that PCLAF remodels DREAM complex, shifting balance from quiescence towards proliferation. Here, we find expression specific proliferating progenitor cells, along with target genes transactivated by injury. Genetic ablation Pclaf impairs...
All living organisms have a biological clock that orchestrates every process and function, this internal operates following circadian rhythm. This is known to influence various clinical indicators such as blood pressure body temperature. Also, the fluctuation of signs symptoms diseases including pain disorders are affected by It has been reported intensity somatic neuropathic show unique patterns depend on passage time. The generation could be explained extrinsic (e.g., physical activity,...