A5100690356- Salivary Gland Tumors Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Pancreatic and Hepatic Oncology Research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Cancer Cells and Metastasis
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Sarcoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Glycosylation and Glycoproteins Research
- Gastric Cancer Management and Outcomes
- Inflammatory Bowel Disease
- Gastrointestinal Tumor Research and Treatment
- Microscopic Colitis
- Lung Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Soft tissue tumor case studies
- Viral-associated cancers and disorders
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Endometrial and Cervical Cancer Treatments
Baylor College of Medicine
2020-2025
Shuguang Hospital
2025
Shanghai University of Traditional Chinese Medicine
2025
China-Japan Friendship Hospital
2024
Peking University
2024
Peking University Third Hospital
2024
The University of Texas Health Science Center at Houston
2013-2022
Indiana University – Purdue University Indianapolis
2022
Creative Commons
2022
Yichang Central People's Hospital
2021-2022
Abstract NUT midline carcinoma (NMC) is an aggressive subtype of squamous cell that typically harbors BRD4/3–NUT fusion oncoproteins block differentiation and maintain tumor growth. In 20% cases, fused to uncharacterized non-BRD gene(s). We established a new patient-derived NMC line (1221) demonstrated it novel NSD3–NUT oncogene. find both necessary sufficient for the blockade maintenance proliferation in cells. binds BRD4, BRD bromodomain inhibitors induce arrest 1221 further NSD3 required...
Thymoquinone (TQ) is a compound extracted from Black Caraway seeds of Nigella Sativa and active against various cancers. Cisplatin (CDDP) the most chemotherapeutic agent in Lung Cancer. Here we report activity TQ non-small cell lung cancer (NSCLC) small (SCLC) lines alone combination with (CDDP).For proliferation MTT assay, viability trypan blue assay for apoptosis Annexin-V FITC were used NCI-H460 NCI-H146 lines. Inhibition invasion by was assessed using Matrigel its affect on release...
Clinical studies and animal experimentation have shown that colonic inflammation is associated with an increased number reactivity of platelets, coagulation abnormalities, enhanced thrombus formation. The objective this study was to define the contribution IL-6 thrombocytosis, exaggerated agonist-induced platelet aggregation, extra-intestinal thrombosis occur during experimental colitis. mature immature life span, thrombin-induced aggregation response, light/dye-induced formation in...
Examination of the prevalence and patterns multimorbidity among elderly in China.Cross-sectional study.More than 10 000 households 28 34 provinces mainland China.11 707 Chinese adults aged 60 over.Prevalence participants. Relative risks were calculated to estimate probability up 14 chronic conditions coexisting with each other. Observed-to-expected (O/E) ratios used analyse multimorbidity.Multimorbidity was present 43.6% respondents from sample population, women having greater compared men....
Abstract Background Activation of nuclear factor erythroid 2-related (Nrf2), which belongs to the basic leucine zipper transcription family, is a strategy for cancer chemopreventive phytochemicals. It an important regulator genes induced by oxidative stress, such as glutathione S-transferases, heme oxygenase-1 and peroxiredoxin 1, activating antioxidant response element (ARE). We hypothesized that (1) citrus coumarin auraptene may suppress premalignant mammary lesions via activation...
Aim: Patients with congenital heart disease-related pulmonary arterial hypertension (CHD-PAH) often require regular follow-up through invasive right catheterization (RHC) to assess disease progression and potential interventions. This study aims evaluate the relationship between arteriovenous oxygen content difference (Ca−vO2) RHC parameters identify blood gas that can aid in a clue about pre-selecting patients CHD-PAH for surgical or percutaneous shunt closure. Methods: In this...
Diseases of the Colon & Rectum ():10.1097/DCR.0000000000003695, February 07, 2025. | DOI: 10.1097/DCR.0000000000003695
// Meixiang Sang 1, 7, * , Mohit Hulsurkar 5, Xiaochong Zhang Haiping Song 8 Dayong Zheng 9 Yan 10 Min Li 2 Jianming Xu 3 Songlin Michael Ittmann 4 Wenliang 6 1 Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University Health Science Center at Houston, TX, USA Department Pathology and Laboratory Cell Biology, Baylor College Immunology, E. DeBakey VAMC, 5 Graduate School Biomedical Sciences, Division Oncology, Internal Memorial Herman Cancer Center, 7 Tumor...
Abstract Ovarian cancer presents as malignant tumors in the female reproductive system with high mortality. MicroRNAs are involved progression of ovarian cancer; however, regulatory relationship among miRs remains unclear. In our study, we verified that both miR‐145 and miR‐133b messenger RNA (mRNA) levels tissues were lower than normal tissues, their mRNA level serum patients was reduced. We demonstrated targeted c‐myc, c‐myc interacted physically DNMT3A cells. confirmed recruited to...
Rationale: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a co-inhibitory checkpoint receptor that expressed by naïve T-cells in lymph nodes (LNs) to inhibit activation against "self" antigens (Ags).In cancer, anti-CTLA-4 blocks inhibitory action, enabling robust of tumor Ags presented draining LNs (TDLNs).However, administered intravenously with limited exposure within TDLNs and immune related adverse events (irAEs) are associated over-stimulation the system.Methods: Herein, we...
Case Reports| February 14 2011 Fine Needle Aspiration of Salivary Glands: 5-Year Experience from a Single Academic Center Subject Area: Pathology and Cell Biology Songlin Zhang; Zhang From the Department Pathology, Louisiana State University Health Science Center, Shreveport, Louisiana, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Richard Bao; Bao Jessica Bagby; Bagby Fleurette Abreo Acta Cytologica (2009) 53 (4): 375–382. https://doi.org/10.1159/000325336...
To the authors' knowledge, diagnostic value of cell block (CB) as an adjunct to ThinPrep liquid-based cytology (LBC) bronchial washing specimens in detection and subclassification pulmonary neoplasms has not been well evaluated. The objective current study was evaluate utility CB this setting.A total 74 concurrently prepared CBs with a diagnosis malignant or suspicious/atypical obtained from bronchoscopy procedures performed during 2009 were reviewed along 28 randomly selected negative...
Epithelial-mesenchymal transition (EMT) is one of the key mechanisms mediating cancer progression. Snail1 has a pivotal role in regulation EMT, involving loss E-cadherin and concomitant upregulation vimentin, among other biomarkers. We have found FSCN1 promoted EMT ovarian cells, but precise mechanism process not been clearly elucidated.The levels snail1 were determined epithelial cancer(EOC) specimen cells by RT-qPCR. The changes makers effects on examined overexpression or depletion EOC...
ABSTRACT Secreted toxins play important roles in the pathogenesis of bacterial infections. In this study, we examined presence secreted cytotoxic factors coagulase-negative staphylococci (CoNS) from bovine clinical and subclinical mastitis. A 34- to 36-kDa protein with cell-rounding activity was found many CoNS strains, especially Staphylococcus chromogenes strains. The caused cell detachment rounding several lines, including HEp-2, Int 407, CHO-K1, Y-1 cells. Native recovered nondenatured...
BACKGROUND. Fine-needle aspiration (FNA) is widely accepted as the initial test to evaluate thyroid nodules; however, inadequate and suboptimal specimens have been 1 of its limitations. Unsatisfactory rates 4.1% 43% reported, but with adequate epithelial cells other limiting factors, such clotting, often are not addressed. The authors' institution has a low unsatisfactory rate, especially for biopsies performed under ultrasound in Interventional Radiology (IR) Department. In addition on-site...
Epithelial-mesenchymal transition (EMT) contributes to tumor invasion, metastasis and drug resistance. AKT activation is key in a number of cellular processes. While many positive regulators for either EMT or have been reported, few negative are established. Through kinase cDNA screen, we identified brain-type creatine (CKB BCK) as potent suppressor both. As ubiquitously expressed normal tissues, CKB significantly downregulated several solid cancer types. Lower expression associated with...
Abstract BACKGROUND: Fine‐needle aspiration (FNA) has been used in the evaluation of lymphadenopathy for a long time and is highly reliable identification metastatic malignancies. However, role FNA assessment new lymphoproliferative disorders continues to be subject debate. The objective current study was evaluate molecular cytogenetic studies diagnoses disorders. METHODS: A retrospective, computer‐based search lymph node FNAs from 2006 2007 performed. Cases with either fluorescence situ...