A5088469510- Lymphatic System and Diseases
- Optical Imaging and Spectroscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Sympathectomy and Hyperhidrosis Treatments
- Diagnosis and Treatment of Venous Diseases
- Systemic Sclerosis and Related Diseases
- Lymphatic Disorders and Treatments
- Nanoplatforms for cancer theranostics
- Vascular Malformations and Hemangiomas
- Cerebrospinal fluid and hydrocephalus
- Medical Imaging Techniques and Applications
- Breast Cancer Treatment Studies
- Body Contouring and Surgery
- Cancer Diagnosis and Treatment
- Photodynamic Therapy Research Studies
- Optical Coherence Tomography Applications
- Advanced Fluorescence Microscopy Techniques
- Thermoregulation and physiological responses
- Angiogenesis and VEGF in Cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiation Dose and Imaging
- Pressure Ulcer Prevention and Management
- Effects of Vibration on Health
- Head and Neck Cancer Studies
- Cancer Cells and Metastasis
Brown Foundation
2014-2024
The University of Texas Health Science Center at Houston
2014-2024
Institute for Molecular Medicine
2011-2021
Rasmussen College
2017
Institute of Molecular Medicine
2014
Baylor College of Medicine
2006-2011
Baylor University
2008
BD Technologie (United States)
2006
Mitchell Institute
2005
Texas A&M University
2004-2005
Purpose: To prospectively demonstrate the feasibility of using indocyanine green, a near-infrared (NIR) fluorophore at minimum dose needed for noninvasive optical imaging lymph nodes (LNs) in breast cancer patients undergoing sentinel node mapping (SLNM). Materials and Methods: Informed consent was obtained from 24 women (age range, 30–85 years) who received intradermal subcutaneous injections 0.31–100 μg green this IRB-approved, HIPAA-compliant, escalation study to find microdose imaging....
Mutations in gene RASA1 have been historically associated with capillary malformation–arteriovenous malformation, but sporadic reports of lymphatic involvement yet to be investigated detail. To investigate the impact mutations system, we performed investigational near-infrared fluorescence imaging and confirmatory radiographic lymphangiography a Parkes–Weber syndrome (PKWS) patient suspected correlated abnormalities against that imaged an inducible Rasa1 knockout mouse. Whole-exome...
Although the importance of lymphatic function is well recognized, lack real-time imaging modalities limits our understanding its role in many diseases. In a phase 0 exploratory study, we used dynamic, near-infrared (NIR) fluorescence to assess extremes architecture and transport healthy human subjects clinically diagnosed with unilateral lymphedema (LE), disease that can be prevalent cancer survivors.Active propulsion was imaged after intradermal injections 25 µg indocyanine green (total...
We compare and contrast the development of optical molecular imaging techniques with nuclear medicine a didactic emphasis for initiating readers into field imaging. The gamma scintigraphy, single-photon emission computed tomography, positron tomography are first briefly reviewed. bioluminescence fluorescence using gene reporter/probes reporters described prior to introducing governing factors autofluorescence excitation light leakage. use dual-labeled, near-infrared excitable radio-labeled...
Functional lymphatic imaging was demonstrated in the abdomen and anterior hindlimb of anesthetized, intact Yorkshire swine by using near-infrared (NIR) fluorescence following intradermal administration 100-200 microl 32 microM indocyanine green (ICG) 64 hyaluronan NIR conjugate to target lymph vascular endothelial receptor (LYVE)-1 on endothelium. employed illumination 780 nm excitation light ( approximately 2 mW/cm(2)) collection 830 generated from agents. Our results show ability image...
Lymphedema affects up to 50% of all breast cancer survivors.Management with pneumatic compression devices (PCDs) is controversial, owing the lack methods directly assess benefit.This pilot study employed an investigational, near-infrared (NIR) fluorescence imaging technique evaluate lymphatic response PCD therapy in normal control and cancer-related lymphedema (BCRL) subjects.Lymphatic propulsion rate, apparent lymph velocity, vessel recruitment were measured before, during, after advanced...
Abstract Objective Lipedema is an inflammatory subcutaneous adipose tissue disease that develops in women and may progress to lipolymphedema, a condition similar lymphedema, which lymphatic dysfunction results irresolvable edema. Because it has been shown dilated vessels, impaired pumping, dermal backflow are associated with presymptomatic, cancer‐acquired this study sought understand whether these abnormal characteristics also characterize early stages of lipedema prior lipolymphedema...
Although fluorescence molecular imaging is rapidly evolving as a new combinational drug/device technology platform for molecularly guided surgery and noninvasive imaging, there remains no performance standards efficient translation of "first-in-humans" fluorescent agents using these devices.The authors employed stable, solid phantom designed to exaggerate the confounding effects tissue light scattering mimic low concentrations (nM-pM) near-infrared dyes expected clinically in order evaluate...
Background Biological evidence reported in the literature supports role of CELSR1 as being essential for valvular function murine lymphatics. Yet thus far, there have been no variants inCELSR1associated with lymphatic dysfunction humans. Case Presentation In this report, a rare early inactivating mutation CELSR1is found to be causal non-syndromic, lower extremity lymphedema family across three generations. Near-infrared fluorescence imaging shows that instead propelled within lumen...
Backprojection tomography is applied to teleseismic P‐wave travel‐time residuals produce a detailed image of the upper mantle beneath Washington and western Oregon. Beneath Cascades volcanic arc from central Oregon subducted Juan de Fuca plate imaged as high‐velocity quasi‐planar feature dipping ∼65°E. Resolution analysis shows that southern Washington, where resolution best, steeply slab extends depth only about 300 km. The may end near this depth, or low‐velocity structure in vicinity...
We report the development of radiative transport model-based fluorescence optical tomography from frequency-domain boundary measurements. The coupled model for describing NIR propagation in tissue is solved by a novel software based on established Attila particle simulation platform. proposed scheme enables prediction measurements with non-contact sources and detectors at minimal computational cost. An adjoint solution-based algorithm implemented dual grids to efficiently assemble...
Current treatment of unilateral breast cancer-related lymphedema (BCRL) is only directed to the afflicted arm.Near-infrared fluorescent imaging (NIRF) arm lymphatic vessel architecture and function in BCRL control subjects revealed a trend increased abnormalities both unafflicted arms with increasing time after onset.These pilot results show that may progress affect clinically "normal" arm, suggest become systemic, rather than local, malady.These findings support further study understand...
BackgroundRecent advancements in near-infrared fluorescence lymphatic imaging (NIRFLI) technology provide opportunities for non-invasive, real-time assessment of contribution the etiology and treatment ulcers. The objective this study was to assess lymphatics subjects with venous leg ulcers using NIRFLI impact a single session sequential pneumatic compression (SPC).MethodsFollowing intradermal microdoses indocyanine green (ICG) as contrast agent, used pilot image 12 active (Clinical,...
To date, no emerging preclinical or clinical near-infrared fluorescence (NIRF) imaging devices for noninvasive and/or surgical guidance have their performances validated on working standards with SI units of radiance that enable comparison quantitative quality assurance. In this work, we developed and deployed a methodology to calibrate stable, solid phantom emission International System Units (SI) mW ·sr <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Ten head and neck cancer survivors diagnosed with lymphedema (HNL) were imaged using near‐infrared fluorescence lymphatic imaging (NIRFLI) prior to immediately after an initial advance pneumatic compression device treatment again 2 weeks of daily at‐home use. Images assessed the impact therapy on drainage. Facial composite measurement scores reduction/increase in external swelling, survey results obtained. After a single treatment, NIRFLI showed enhanced uptake drainage all subjects. areas...
Rationale: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a co-inhibitory checkpoint receptor that expressed by naïve T-cells in lymph nodes (LNs) to inhibit activation against "self" antigens (Ags).In cancer, anti-CTLA-4 blocks inhibitory action, enabling robust of tumor Ags presented draining LNs (TDLNs).However, administered intravenously with limited exposure within TDLNs and immune related adverse events (irAEs) are associated over-stimulation the system.Methods: Herein, we...