A5080574067- Osteoarthritis Treatment and Mechanisms
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Knee injuries and reconstruction techniques
- Genomics, phytochemicals, and oxidative stress
- Coronary Interventions and Diagnostics
- Glutathione Transferases and Polymorphisms
- Lower Extremity Biomechanics and Pathologies
- Periodontal Regeneration and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Bone health and treatments
- Systemic Lupus Erythematosus Research
- Molecular Biology Techniques and Applications
- Poisoning and overdose treatments
- Public Administration and Political Analysis
- Drug-Induced Hepatotoxicity and Protection
- Animal testing and alternatives
- Antiplatelet Therapy and Cardiovascular Diseases
- Pesticide Exposure and Toxicity
- Parkinson's Disease Mechanisms and Treatments
- Law and Political Science
- Synthetic Organic Chemistry Methods
- Neurological disorders and treatments
- Cancer Research and Treatments
- Rheumatoid Arthritis Research and Therapies
Rice University
2020-2024
Louisiana State University Health Sciences Center Shreveport
2010-2017
Louisiana State University Health Sciences Center New Orleans
2010
Istituto Nazionale di Fisica Nucleare, Galileo Galilei Institute for Theoretical Physics
1885
Strateji Araşdırmalar Mərkəzi
1885
Abstract Background Activation of nuclear factor erythroid 2-related (Nrf2), which belongs to the basic leucine zipper transcription family, is a strategy for cancer chemopreventive phytochemicals. It an important regulator genes induced by oxidative stress, such as glutathione S-transferases, heme oxygenase-1 and peroxiredoxin 1, activating antioxidant response element (ARE). We hypothesized that (1) citrus coumarin auraptene may suppress premalignant mammary lesions via activation...
Improved spread of transduction in the central nervous system (CNS) was achieved from intravenous administration adeno-associated virus serotype-9 (AAV9) to neonatal rats. Spinal lower motor neuron efficiency estimated be 78% using highest vector dose tested at a 12-week interval. The widespread expression could aid studying diseases that affect both spinal cord and brain, such as amyotrophic lateral sclerosis (ALS). protein most relevant neuropathology ALS is transactive response...
Pathological inclusions containing transactive response DNA-binding protein 43 kDa (TDP-43) are common in several neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). TDP-43 normally localizes predominantly to the nucleus, but during disease progression, it mislocalizes cytoplasm. We expressed rats by an adeno-associated virus (AAV9) gene transfer method that transduces neurons throughout central nervous system (CNS). To mimic aberrant cytoplasmic found disease, we a...
Inflammatory arthritis is a chronic disease, resulting in synovitis and subchondral bone area destruction, which can severely affect patient's quality of life. The most common form inflammatory rheumatoid (RA) many the disease mechanisms are not well understood. collagen-induced (CIA) mouse model similar to RA as it exhibits joint space narrowing erosion involves factors cellular players that have been implicated pathogenesis. Quantitative data for progression models difficult obtain serum...
Parkinson's disease (PD) is characterized by the loss of dopamine-producing neurons in nigrostriatal system. Numerous researchers past have attempted to track progression dopaminergic depletion PD. We applied a quantitative non-invasive PET imaging technique follow this degeneration process an MPTP-induced mouse model The VMAT2 ligand 18F-DTBZ (AV-133) was used as radioactive tracer our experiments monitor changes Intraperitoneal administrations MPTP (a neurotoxin) were delivered mice at...
Osteochondral tissue repair represents a common clinical need, with multiple approaches in engineering and regenerative medicine being investigated for the of defects articular cartilage subchondral bone. A full thickness rabbit femoral condyle defect is clinically relevant model an articulating load bearing joint surface investigation osteochondral by various cell-, biomolecule-, biomaterial-based implants. In this protocol, we describe methodology 1.5- to 2-h surgical procedure generation...
Nuclear factor erythroid 2‐related (Nrf2) is a positive regulator of the antioxidant response element (ARE). We hypothesized that Nrf2 knockout (KO) mice would be more susceptible to mammary carcinogenesis than their wild‐type littermates (WT). Female were dosed with medroxyprogesterone acetate and 7,12‐dimethylbenz[a]anthracene for premalignant study (n=10) tumor (34 WT, 30 KO mice). After 10 weeks (premalignant study), all treated carcinogen exhibited marked intraductal proliferation,...
Osteochondral defects present a unique clinical challenge due to their combination of phenotypically distinct cartilage and bone, which require specific, stratified biochemical cues for tissue regeneration. Furthermore, the articular exhibits significantly worse regeneration than bone its largely acellular avascular nature, prompting significant demand regenerative therapies. To address these challenges, we have developed bilayered, modular hydrogel system that enables click...