A5006106260- Microscopic Colitis
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Immune Response and Inflammation
- Gastrointestinal motility and disorders
- Immune Cell Function and Interaction
- Diet and metabolism studies
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Inflammatory mediators and NSAID effects
- Probiotics and Fermented Foods
- Eosinophilic Esophagitis
- Cancer, Stress, Anesthesia, and Immune Response
- Liver Diseases and Immunity
- Digestive system and related health
- Clostridium difficile and Clostridium perfringens research
- Cell Adhesion Molecules Research
- Pancreatitis Pathology and Treatment
- Fatty Acid Research and Health
- Esophageal and GI Pathology
- Sphingolipid Metabolism and Signaling
- Metastasis and carcinoma case studies
National Defense Medical College
2015-2024
International Data Group (Sweden)
2024
Ministry of Health Labour and Welfare
2024
Yamaguchi University
2023
National Defense Medical College Hospital
2008-2022
National Defence Medical Centre
2017-2020
Louisiana State University Health Sciences Center Shreveport
2013
Kurume University
2013
Keio University
2000-2005
Tokyo Metropolitan Ohtsuka Hospital
2005
Although nonalcoholic steatohepatitis (NASH) is associated with hypercholesterolemia, the underlying mechanisms of this association have not been clarified. We aimed to elucidate precise role cholesterol in pathophysiology NASH. C57BL/6 mice were fed a control, high-cholesterol (HC), methionine-choline-deficient (MCD), or MCD+HC diet for 12 weeks HC, high-fat (HF), HF+HC 24 weeks. Increased intake accelerated liver fibrosis both mouse models without affecting degree hepatocellular injury...
Clinical studies and animal experimentation have shown that colonic inflammation is associated with an increased number reactivity of platelets, coagulation abnormalities, enhanced thrombus formation. The objective this study was to define the contribution IL-6 thrombocytosis, exaggerated agonist-induced platelet aggregation, extra-intestinal thrombosis occur during experimental colitis. mature immature life span, thrombin-induced aggregation response, light/dye-induced formation in...
First reported in 1955, Cronkhite-Canada syndrome (CCS), a rare characterized by ectodermal abnormalities and inflammatory changes of the gastrointestinal tract mucosa, has been associated with poor prognosis life-threatening malignant complications. In large population survey, we endeavored to characterize course treatment outcome CCS through clinical endoscopic assessment, explore its optimal surveillance strategy.A retrospective analysis 210 patients was conducted via questionnaire-based...
Summary Although beneficial roles of probiotics for inflammatory bowel diseases have been reported, their direct action on immune cells has not elucidated. In this study, we investigated how three species Bifidobacterium and Enterococcus faecalis differentially modulate production cytokines from lipopolysaccharide (LPS)‐stimulated macrophages in vitro using RAW264.7 cells. The mRNA levels proinflammatory were remarkably increased after exposure to LPS, E. alone LPS combined with . contrast,...
ABSTRACT HIF-1 is active in hypoxia, such as inflamed mucosa, and epithelium has been reported to control mucosa IBD models. Although T cells play an important role for pathogenesis of IBD, the function remains be elucidated. We aimed clarify with focus on balance between Treg Teff. Double immunohistochemistry colonic patients showed that was expressed infiltrating suggesting involved pathogenesis. DSS administration cell-specific HIF-1α KO mice more severe inflammation than up-regulation...
Lipoprotein lipase (LPL) plays a central role in incorporating plasma lipids into tissues and regulates lipid metabolism energy balance the human body. Conversely, LPL expression is almost absent normal adult livers. Therefore, its physiological liver remains unknown. We aimed to elucidate of pathophysiology nonalcoholic steatohepatitis (NASH), hepatic manifestation obesity. Hepatic stellate cell (HSC)-specific LPL-knockout (LplHSC-KO ) mice, LPL-floxed (Lplfl/fl or double-mutant toll-like...
Abstract Background and Aim: Vascular endothelial growth factor receptor 3 (VEGFR3) LYVE‐1 are specifically expressed in the endothelium of lymphatic systems. VEGF‐C, D, FOXC2, Prox 1, SOX18 known to play central roles development. We investigated expression regulatory molecules for lymphangiogenesis duodenal mucosa idiopathic intestinal lymphangiectasia. Methods: Biopsy samples were obtained from biopsies patients with lymphangiectasia complicated protein‐losing white spot lesions which was...
Takeshi Takajo, Kengo Tomita, Hanae Tsuchihashi, Shingo Enomoto, Masaaki Tanichi, Hiroyuki Toda, Yoshikiyo Okada, Hirotaka Furuhashi, Nao Sugihara, Akinori Wada, Kazuki Horiuchi, Kenichi Inaba, Yoshinori Hanawa, Naoki Shibuya, Kazuhiko Shirakabe, Higashiyama, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Shigeaki Nagao, Katsunori Kimura, Soichiro Miura, Kunio Shimizu, Ryota Hokari. Gut and Liver 2019;13:325-32. https://doi.org/10.5009/gnl18296
Chitinase 3-like 1 (CHI3L1), an 18-glycosyl hydrolase-related molecule, is a member of the enzymatically inactive chitinase-like protein family. Serum levels CHI3L1 are strongly correlated with hepatic fibrosis progression during many liver diseases. Therefore, this could be involved in development pathology; however, its role has not been elucidated. We aimed to elucidate pathophysiology fibrosis.
Abstract Background and Aim Dietary emulsifiers are widely used in processed foods officially approved as safe for intake. However, recent studies have demonstrated that some alter the colonic microbiota, leading to low‐grade inflammation, mice. The effect of dietary on small‐intestinal which is important gut immunity, has not been studied. We aimed investigate a representative emulsifier, polysorbate‐80 (P80), microbiota normal Methods Some mice were pretreated with P80 8 weeks or without...
Numerous reports have shown that a diet containing large amounts of trans fatty acids (TFAs) is major risk factor for metabolic disorders. Although recent studies TFAs promote intestinal inflammation, the underlying mechanisms are unknown. In this study, we examined effects dietary fat on dextran sodium sulphate (DSS)-induced colitis. C57 BL/6 mice were fed 1·3% (mainly C16:1, C18:1, C18:2, C20:1, C20:2 and C22:1), then colitis was induced with 1·5% DSS. Colonic damage assessed, mRNA levels...
Although the incidence of inflammatory bowel diseases (IBD) in Japan has increased, prevalence celiac disease is considered very low with lowest genetic disposition. IBD reported as most common comorbidity because high positive rate serological markers. The aim this study was to examine current disease, especially patients Japan, where both wheat consumption and have increased. A total 172 190 controls were screened for serum antibody tissue transglutaminase deaminated gliadin peptide. In...
Abstract Background and Aim Studies on the characteristics of elderly‐onset ulcerative colitis (EOUC) non‐elderly‐onset (NEOUC) have reported conflicting findings. The aim this study was to compare disease EOUC NEOUC by analyzing database Japanese nationwide inflammatory bowel (IBD) registry. Methods We analyzed age onset, sex, severity, extent in patients with that were newly diagnosed registered within 1 year between 2004 2009 ( n = 28 179). also medical treatment, rate IBD‐related...
The artificial sweetener acesulfame potassium (ACK) is officially approved as safe for intake and has been used in processed foods. However, ACKs have reported to induce metabolic syndrome, along with alteration of the gut microbiota mice. In recent years, studies suggested that this promotes myeloperoxidase reactivity Crohn's disease-like ileitis. We aimed investigate effect ACK on intestinal mucosa normal mice.Acesulfame was administered C57BL/6J mice (8 weeks old) via free drinking....
Dietary fat is known to modulate immune functions. Intake of an animal fat-rich diet has been linked increased risk inflammation; however, little about how ingestion directly affects intestinal function. The objective this study was assess the effect butter feeding on lymphocyte migration in mucosa and changes adhesion molecules cytokines involved effect.T-lymphocytes isolated from spleen were fluorescence-labeled injected into recipient mice. Butter administered duodenum, villus...
Background/Aims Anti-tumor necrosis factor drugs (anti-TNF) and thiopurines are important treatment options in patients with inflammatory bowel disease (IBD), including during pregnancy. However, there limited data on the benefit/risk profile of anti-TNF pregnancy Asia. The aim this study was to analyze outcomes female Japanese IBD treated and/or thiopurines. Methods This cross-sectional assessed 72 women IBD. Pregnancy were compared among 31 pregnancies without exposure infliximab (IFX),...
Summary Clinical studies using omega-3 polyunsaturated fatty acids (ω3-PUFA) to Crohn's disease (CD) are conflicting. Beneficial effects of dietary ω3-PUFA intake in various experimental inflammatory bowel (IBD) models have been reported. However, animal large intestinal inflammation used all previous studies, and the effect ω3 fat an model small has not We hypothesized that different between intestine. The aim this study was determine whether direct is beneficial for inflammation....
Psychological stress is an environmental factor considered to be a precipitating of inflammatory bowel disease. Interleukin (IL)-18 plays role in stress-induced aggravation some diseases. The aim this study was establish model murine colitis exacerbated by psychological and clarify the IL-18 model. Male C57Bl/6 mice IL-18(-/-) were used for study. received dextran sulfate sodium (DSS) induction colitis. Some exposed using communication box. Body weight, colonic length, histological...
Liver fibrosis is a life-threatening disorder for which no approved therapy available. Recently, we reported that mouse hepatic stellate cell (HSC) activation increased free cholesterol (FC) accumulation, partly by enhancing signaling through sterol regulatory element-binding protein 2 (SREBP2) and microRNA-33a (miR-33a), resulted in HSC sensitization to transforming growth factor-β (TGFβ)-induced "vicious cycle" of liver fibrosis.Human HSCs were isolated from surgical specimens control...
In Crohn's disease (CD), assessment of activity and extension is important for clinical management. Endoscopy the most reliable tool evaluating in these patients it distinguishes between lesions based on ulcer, erosion, redness. Magnetic resonance imaging (MRI) less invasive than endoscopy; however, sensitivity MRI detecting believed to be lower, whether can detect milder has not been studied. The aim this study was compare detection ability magnetic enterocolonography (MREC) with...
Lymphatic failure is a histopathological feature of inflammatory bowel disease (IBD). Recent studies show that interaction between platelets and podoplanin on lymphatic endothelial cells (LECs) suppresses lymphangiogenesis. We aimed to investigate the role in process colitis, which likely be through modulation Lymphangiogenesis colonic mucosal specimens from patients with IBD was investigated by studying mRNA expression lymphangiogenic factors histologically examining vessel (LV) densities....