A5020924139- Helicobacter pylori-related gastroenterology studies
- Microscopic Colitis
- Inflammatory Bowel Disease
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Immune Response and Inflammation
- Hepatitis C virus research
- Diet and metabolism studies
- Inflammatory mediators and NSAID effects
- Probiotics and Fermented Foods
- Eosinophilic Esophagitis
- Cancer, Stress, Anesthesia, and Immune Response
- Digestive system and related health
- IL-33, ST2, and ILC Pathways
- Hepatitis B Virus Studies
- Sphingolipid Metabolism and Signaling
- Animal Virus Infections Studies
- Liver Diseases and Immunity
- Pancreatitis Pathology and Treatment
- Clostridium difficile and Clostridium perfringens research
- Immune Cell Function and Interaction
- Diet, Metabolism, and Disease
- Neonatal Respiratory Health Research
- Platelet Disorders and Treatments
National Defense Medical College
2015-2024
International Data Group (Sweden)
2024
Ministry of Health Labour and Welfare
2024
University of California, Los Angeles
2023
Tokyo Medical University Hospital
2023
UCLA Medical Center
2020-2023
Harbor–UCLA Medical Center
2020-2022
Children's Hospital of Orange County
2020
National Defense Medical College Hospital
2019
Kurume University
2013
Background and Purpose— Abnormal vascular remodeling triggered by hemodynamic stresses inflammation is believed to be a key process in the pathophysiology of intracranial aneurysms. Numerous studies have shown infiltration inflammatory cells, especially macrophages, into aneurysmal walls humans. Using mouse model aneurysms, we tested whether macrophages play critical roles formation Methods— Intracranial aneurysms were induced adult male mice using combination single injection elastase...
Although nonalcoholic steatohepatitis (NASH) is associated with hypercholesterolemia, the underlying mechanisms of this association have not been clarified. We aimed to elucidate precise role cholesterol in pathophysiology NASH. C57BL/6 mice were fed a control, high-cholesterol (HC), methionine-choline-deficient (MCD), or MCD+HC diet for 12 weeks HC, high-fat (HF), HF+HC 24 weeks. Increased intake accelerated liver fibrosis both mouse models without affecting degree hepatocellular injury...
Mechanisms of formation and growth intracranial aneurysms are poorly understood. To investigate the pathophysiology aneurysms, an animal model aneurysm yielding a high incidence large within short incubation period is needed. We combined two well-known clinical factors associated with human hypertension degeneration elastic lamina, to induce in mice. Roles matrix metalloproteinases (MMPs) this were investigated using doxycycline, broad-spectrum MMP inhibitor, knockout Hypertension was...
Aortic aneurysms are common among the elderly population. A large majority of aortic located at two distinct aneurysm-prone regions, abdominal aorta and thoracic involving ascending aorta. In this study, we combined factors that associated with human aneurysms, hypertension degeneration elastic lamina, to induce an aneurysm in mice. Roles hemodynamic conditions formation were assessed using different methods for inducing antihypertensive agents. 9-week-old C57BL/6J male mice, was induced by...
Background and Purpose— An increasing number of unruptured intracranial aneurysms are being detected, partly due to the increased use brain imaging techniques. Pharmacological stabilization for prevention aneurysmal rupture could potentially be an attractive alternative approach clipping or coiling in patients with aneurysms. We have developed a mouse model aneurysm that recapitulates key features In this model, subarachnoid hemorrhage from causes neurological symptoms can easily detected by...
PD-L1 (also B7-H1) and PD-L2 B7-DC) are ligands for programmed death-1 (PD-1), which is a member of the CD28/B7 superfamily costimulatory molecules plays an inhibitory role on periphery. Impaired regulation this system may cause disruption to self-tolerance leading autoimmunity; however, these in liver unknown. Therefore, we examined expression PD-1, PD-L1, autoimmune diseases.We hepatitis (AIH) primary biliary cirrhosis (PBC) with no previous medical treatment using immunohistochemical...
Summary Although beneficial roles of probiotics for inflammatory bowel diseases have been reported, their direct action on immune cells has not elucidated. In this study, we investigated how three species Bifidobacterium and Enterococcus faecalis differentially modulate production cytokines from lipopolysaccharide (LPS)‐stimulated macrophages in vitro using RAW264.7 cells. The mRNA levels proinflammatory were remarkably increased after exposure to LPS, E. alone LPS combined with . contrast,...
ABSTRACT HIF-1 is active in hypoxia, such as inflamed mucosa, and epithelium has been reported to control mucosa IBD models. Although T cells play an important role for pathogenesis of IBD, the function remains be elucidated. We aimed clarify with focus on balance between Treg Teff. Double immunohistochemistry colonic patients showed that was expressed infiltrating suggesting involved pathogenesis. DSS administration cell-specific HIF-1α KO mice more severe inflammation than up-regulation...
Lipoprotein lipase (LPL) plays a central role in incorporating plasma lipids into tissues and regulates lipid metabolism energy balance the human body. Conversely, LPL expression is almost absent normal adult livers. Therefore, its physiological liver remains unknown. We aimed to elucidate of pathophysiology nonalcoholic steatohepatitis (NASH), hepatic manifestation obesity. Hepatic stellate cell (HSC)-specific LPL-knockout (LplHSC-KO ) mice, LPL-floxed (Lplfl/fl or double-mutant toll-like...
Abstract Background and Aim: Vascular endothelial growth factor receptor 3 (VEGFR3) LYVE‐1 are specifically expressed in the endothelium of lymphatic systems. VEGF‐C, D, FOXC2, Prox 1, SOX18 known to play central roles development. We investigated expression regulatory molecules for lymphangiogenesis duodenal mucosa idiopathic intestinal lymphangiectasia. Methods: Biopsy samples were obtained from biopsies patients with lymphangiectasia complicated protein‐losing white spot lesions which was...
Although the immunoregulatory effects of omega-3 fatty acid and adiponectin have been postulated, their role in intestinal inflammation is controversial. The aim this study was to determine whether dietary fat intake influences activity colonic through modulating system.C57BL/6 mice received dextran sulfate sodium for induction colitis. Mice were fed a control diet, fat-rich omega-6 or saturated diet. Some administered peroxisome proliferator activated receptor-gamma; agonist, pioglitazone....
Sustained hemodynamic stresses, especially high blood flow, result in flow-induced outward vascular remodeling. Our previous study showed that macrophage depletion reduced remodeling of the rat common carotid artery, indicating macrophages are critical Macrophage is known to release proteinases, including matrix metalloproteinases (MMPs). Degradation and loosening extracellular by MMPs may facilitate Therefore, we assessed functions using flow-augmented artery model mice. We validated...
Human noroviruses (NoVs) are a major cause of non-bacterial gastroenteritis. Although histo-blood group antigens (HBGAs) have been implicated in the initial binding NoV, mechanism that before internalization is not clear. To determine involvement NoVs and HBGAs cell binding, we examined localization NoV virus-like particles (VLPs) human intestinal line ileum biopsy specimens by immunofluorescence microscopy. The localizations Ueno 7k VLPs (genogroup II.6) each HBGA (type H1-, H2- Leb-HBGAs)...
Takeshi Takajo, Kengo Tomita, Hanae Tsuchihashi, Shingo Enomoto, Masaaki Tanichi, Hiroyuki Toda, Yoshikiyo Okada, Hirotaka Furuhashi, Nao Sugihara, Akinori Wada, Kazuki Horiuchi, Kenichi Inaba, Yoshinori Hanawa, Naoki Shibuya, Kazuhiko Shirakabe, Higashiyama, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Shigeaki Nagao, Katsunori Kimura, Soichiro Miura, Kunio Shimizu, Ryota Hokari. Gut and Liver 2019;13:325-32. https://doi.org/10.5009/gnl18296
Chitinase 3-like 1 (CHI3L1), an 18-glycosyl hydrolase-related molecule, is a member of the enzymatically inactive chitinase-like protein family. Serum levels CHI3L1 are strongly correlated with hepatic fibrosis progression during many liver diseases. Therefore, this could be involved in development pathology; however, its role has not been elucidated. We aimed to elucidate pathophysiology fibrosis.
Abstract Background and Aim Dietary emulsifiers are widely used in processed foods officially approved as safe for intake. However, recent studies have demonstrated that some alter the colonic microbiota, leading to low‐grade inflammation, mice. The effect of dietary on small‐intestinal which is important gut immunity, has not been studied. We aimed investigate a representative emulsifier, polysorbate‐80 (P80), microbiota normal Methods Some mice were pretreated with P80 8 weeks or without...
Sustained hemodynamic stresses, especially sustained high blood flow, result in flow-induced outward vascular remodeling. Mechanisms that link stresses to remodeling are not well understood. Inflammatory cells, known for their release of proteinases, including matrix metalloproteinases (MMPs), emerging as key mediators various tissue Using a flow-augmented common carotid artery model rats, we tested whether macrophages play critical roles adaptive response an increase flow. Left ligation...
Numerous reports have shown that a diet containing large amounts of trans fatty acids (TFAs) is major risk factor for metabolic disorders. Although recent studies TFAs promote intestinal inflammation, the underlying mechanisms are unknown. In this study, we examined effects dietary fat on dextran sodium sulphate (DSS)-induced colitis. C57 BL/6 mice were fed 1·3% (mainly C16:1, C18:1, C18:2, C20:1, C20:2 and C22:1), then colitis was induced with 1·5% DSS. Colonic damage assessed, mRNA levels...
Although the incidence of inflammatory bowel diseases (IBD) in Japan has increased, prevalence celiac disease is considered very low with lowest genetic disposition. IBD reported as most common comorbidity because high positive rate serological markers. The aim this study was to examine current disease, especially patients Japan, where both wheat consumption and have increased. A total 172 190 controls were screened for serum antibody tissue transglutaminase deaminated gliadin peptide. In...