Thymoquinone (TQ) is a compound extracted from Black Caraway seeds of Nigella Sativa and active against various cancers. Cisplatin (CDDP) the most chemotherapeutic agent in Lung Cancer. Here we report activity TQ non-small cell lung cancer (NSCLC) small (SCLC) lines alone combination with (CDDP).For proliferation MTT assay, viability trypan blue assay for apoptosis Annexin-V FITC were used NCI-H460 NCI-H146 lines. Inhibition invasion by was assessed using Matrigel its affect on release...

Cancer cachexia affects many advanced non-small-cell lung cancer (NSCLC) patients. Cachexia index (CXI) was developed to assess the degree of in these patients.Patients with metastatic NSCLC diagnosed between January 1, 2000, and June 30, 2011, at our institution were retrospectively studied. Abdominal computed tomography scans done within 1 month diagnosis reviewed estimate skeletal muscle area (SMA) (SMI) L3 level. CXI as follows: [Formula: see text] where SMI is index, Alb serum albumin,...

The incidence rates of travelers' diarrhea (TD) have remained high for the last 50 years. More recently, there been increasing recommendations self-initiated therapy and use prophylactic drugs TD. We examined in vitro susceptibilities commonly used antibiotics against TD pathogens 1997. now examine 456 enteropathogens isolated from adult travelers to Mexico, India, Guatemala with acquired between 2006 2008 determine changes susceptibility 10 different antimicrobials by agar dilution method....

A 65-year-old male presented after a positive Cologuard testing. He was asymptomatic at presentation, with no reported complaints of fever, chills, abdominal pain, diarrhea, constipation, hematochezia, or unexpected weight loss. CT imaging the abdomen and pelvis revealed 2 cm mass rectosigmoid junction single enlarged lymph node nearby measuring 2.7 x 1.6 cm, raising suspicion for regional metastatic adenopathy. underwent colonoscopy, which confirmed mass. Biopsy results showed...

Patients with severe aortic stenosis (AS) and left ventricular (LV) dysfunction demonstrate improvement in injection fraction (LVEF) after valve replacement (AVR). The timing magnitude of recovery patients very low LVEF (≤ 25%) surgical or transcatheter AVR is not well studied.

Lung cancer is the leading cause of cancer-related mortality and strongly linked with smoking. We sought to determine whether major stressful life events (e.g. divorce) are also a risk factor for developing lung cancers.We performed matched case-control study. Cases (CA) were patients diagnosed within previous 12 months. Controls (CO) without prior history malignancy. Data on collected using modified Holmes-Rahe stress scale. The primary endpoint was odds having event between CA CO. A sample...

Small cell lung cancer (SCLC) is a very aggressive with poor outcome if left untreated, but it also one of the most chemotherapy responsive cancers. Overall has prognosis especially resistant to first line treatment. Second not been beneficial in SCLC as opposed breast and lymphoma. In last few years topotecan only drug that approved by food administration (FDA) for second treatment Japan another drug, amrubicin approved. There are many combinations different chemotherapies available...

A man in his 60s presented with a gradual progressive right-sided neck mass. Initial core biopsy was inconclusive and he treated short course of oral prednisone for presumed sarcoidosis. Two months later, the patient developed worsening dysphagia, hoarseness voice, dyspnea, weight loss. Physical examination revealed bilateral cervical right axillary lymphadenopathy. lymph node excisional performed immunohistochemistry diffusely positive OCT4, SALL4, CD117, PLAP, confirming diagnosis...

Abstract Background: In the progression of their disease, Alzheimer's disease (AD) patients have been observed to demonstrate various clinical features reminiscent children. Based on behavioral, neurological and neuropathological findings, Reisberg et al . noted relationships between development dementia proposed ‘retrogenesis’ model. Methods: The functional assessment staging procedure (FAST) was used for ability, Tanaka–Binet intelligence scale (TB scale) assess intellectual ability in 24...

Background: HAART has significantly reduced AIDS-related morbidity in children.However, limited evidence is available from developing countries regarding patterns of opportunistic illnesses.We describe these events and their associated factors children with AIDS Brazil.Methods: This study based on two representative retrospective multi-center cohorts including a total 1,859 AIDS, infected via mother-to-child transmission (MTCT), between 1983-2002.Opportunistic illnesses were described...

Abstract Purpose: To determine whether SUV max(Maximum Standardized Uptake Value) of primary lung tumor on FDGPET/CT scan (Fluorodeoxy Glucose -Positron Emission Tomography/Computed Tomography) at baseline has any role in predicting survival patients with Stage IV NSCLC. Background: Lung Cancer is the leading cause mortality both sexes United States and Worldwide. About 70% cancer present locally advanced or metastatic disease diagnosis. In general poor prognosis 5-year 2 percent. Limited...

1575 Background: Lung cancer is the leading cause of cancer-related mortality linked with smoking, though only 6-18% heavy smokers die lung cancer. We hypothesized that major stressful life events are a risk factor for developing Methods: In our matched case-control study, cases (CA) were patients diagnosed within past 12 months. Controls (CO) without prior history malignancy. CA and CO age, gender smoking status. Smokers had at least 10 packs/years smoking. Data was collected using...

Unintentional weight loss, a first clinical sign of muscle wasting, is major threat to cancer survival without defined etiology. We previously identified in mice that p38β MAPK mediates cancer-induced wasting by stimulating protein catabolism. However, whether this mechanism relevant humans unknown. In study, we recruited men with and loss (CWL) or stable (CWS), non-cancer controls (NCC), who were consented rectus abdominis (RA) biopsy blood sampling (n = 20/group). the RA both CWS CWL,...

e16009 Background: SCHNC is a common malignancy and approximately 60% of patients present with locally advanced disease. There paucity data directly comparing Cx CDDP concurrent radiation in SCHNC. We retrospectively reviewed charts treated and/or along efficacy outcomes an academic cancer center. Methods: Ninety-five were (100 mg/m2 day 1, 22, 43) or (400mg/m2 on -7 250mg/m2 weekly) at our institution between January 2006 June 2011. Forty-four (group A), 24 B) 27 initially started but...

Stiff person syndrome (SPS) is a rare, debilitating neurological illness characterised by rigidity and spasms of the axial muscles, causing severe restrictions to mobility. SPS can be classic, partial or paraneoplastic. We report case young woman who presented with seizures painful thoracolumbar muscles was subsequently diagnosed SPS. Serological work revealed glutamic acid decarboxylase (GAD) antibodies imaging showed large mediastinal mass. The patient underwent surgical resection mass...

Abstract Introduction/Objective Chordoma is a rare tumor most commonly arising in the sacrococcygeal region from notochord remnants. Usually, these tumors are locally invasive and recurrent, but do not have capability to metastasize. A newly described aggressive variant called poorly differentiated chordoma different than conventional that it does well-differentiated histologic appearance of also exhibits loss SMARCB1/INI1. Methods Herein, we describe case with SMARCB1/INI1 loss, concurrent...