Johncy John Kachira

ORCID: 0000-0003-0544-9491
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Research Areas
  • Cancer Immunotherapy and Biomarkers
  • Chronic Myeloid Leukemia Treatments
  • Peptidase Inhibition and Analysis
  • Sarcoma Diagnosis and Treatment
  • Acute Myeloid Leukemia Research
  • Cancer, Stress, Anesthesia, and Immune Response
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Colorectal Cancer Treatments and Studies
  • Immune Cell Function and Interaction
  • Rheumatoid Arthritis Research and Therapies
  • Heparin-Induced Thrombocytopenia and Thrombosis
  • Myasthenia Gravis and Thymoma
  • Cancer Diagnosis and Treatment
  • Testicular diseases and treatments
  • Glycogen Storage Diseases and Myoclonus
  • Chronic Lymphocytic Leukemia Research
  • Autoimmune Neurological Disorders and Treatments
  • Multiple Myeloma Research and Treatments

The University of Texas MD Anderson Cancer Center
2022-2025

Objective In this study, we explored physicians’ level of experience with patients rheumatoid arthritis (RA) who used tobacco; their views on the effects tobacco use efficacy RA treatments; and experiences attitudes respect to cessation programs. Methods We conducted qualitative, semi‐structured interviews 20 physicians (10 primary‐care [PCPs] 10 rheumatologists). Results The had been in clinical practice for a mean 9.9 years. Research themes included 1) risk perception smoking, 2) aids...

10.1002/acr.25500 article EN Arthritis Care & Research 2025-01-19

Patients with pre-existing autoimmune disorders and cancer considering immune checkpoint inhibitors (ICIs) need to receive balanced information about the benefits risk of developing immune-related adverse events (irAEs) flare-ups their disease. To assess learning needs patients disease regarding ICI treatment, we interviewed 29 from a comprehensive center, whom 20 had received 9 were candidates at US Cancer Center. In-depth semi-structured interviews conducted August 2021 January 2022....

10.3390/cancers15154004 article EN Cancers 2023-08-07

A man in his 60s presented with a gradual progressive right-sided neck mass. Initial core biopsy was inconclusive and he treated short course of oral prednisone for presumed sarcoidosis. Two months later, the patient developed worsening dysphagia, hoarseness voice, dyspnea, weight loss. Physical examination revealed bilateral cervical right axillary lymphadenopathy. lymph node excisional performed immunohistochemistry diffusely positive OCT4, SALL4, CD117, PLAP, confirming diagnosis...

10.1080/08998280.2023.2167184 article EN Baylor University Medical Center Proceedings 2023-01-24

Stiff person syndrome (SPS) is a rare, debilitating neurological illness characterised by rigidity and spasms of the axial muscles, causing severe restrictions to mobility. SPS can be classic, partial or paraneoplastic. We report case young woman who presented with seizures painful thoracolumbar muscles was subsequently diagnosed SPS. Serological work revealed glutamic acid decarboxylase (GAD) antibodies imaging showed large mediastinal mass. The patient underwent surgical resection mass...

10.1136/bcr-2022-250639 article EN BMJ Case Reports 2022-07-01

Carfilzomib is a selective proteosome inhibitor that commonly used in the treatment of relapsed or refractory multiple myeloma. has been associated with respiratory side effects. It can rarely also cause fatal pulmonary toxicity. We present case man his 50s plasma cell leukaemia who was initiated on carfilzomib and dexamethasone. He developed severe pneumonitis requiring oxygen via high-flow nasal cannula. After an extensive workup, temporal relationship between use exacerbation symptoms...

10.1136/bcr-2022-251173 article EN BMJ Case Reports 2022-07-01
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