A5051324146- Cancer, Hypoxia, and Metabolism
- Biochemical and Molecular Research
- Metabolism and Genetic Disorders
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Chemokine receptors and signaling
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Barrier Structure and Function Studies
- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Adenosine and Purinergic Signaling
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nutrition and Health in Aging
University of Oklahoma Health Sciences Center
2018-2025
Weatherford College
2024
Versus Arthritis
2024
Fudan University
2024
Chongqing University of Science and Technology
2023-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2019-2023
Sun Yat-sen University
2017-2023
Fudan University Shanghai Cancer Center
2023
Shanghai Cancer Institute
2023
Shanghai Medical College of Fudan University
2023
Background & AimsPancreatic cancer has the highest prevalence of cancer-associated cachexia among all cancers. ZIP4 promotes pancreatic progression by regulating oncogenic miR-373, and perturbation circular RNAs (circRNAs) is associated with aggressiveness. This study aimed to identify circRNAs involved in ZIP4/miR-373–driven growth decipher underlying mechanism.MethodsDifferentially expressed potential targets microRNA were identified through silico analysis. The RNA interactions determined...
With limited treatment options, cachexia remains a major challenge for patients with cancer. Characterizing the interplay between tumor cells and immune microenvironment may help identify potential therapeutic targets cancer cachexia. Herein, we investigate critical role of macrophages in potentiating pancreatic induced muscle wasting via promoting TWEAK (TNF-like weak inducer apoptosis) secretion from tumor. Specifically, depletion reverses degradation by cells. Macrophages induce...
Abstract Purpose: C-X-C chemokine receptor type 2 (CXCR2) is a key regulator that drives immune suppression and inflammation in tumor microenvironment. CXCR2-targeted therapy has shown promising results several solid tumors. However, the underlying mechanism of CXCR2-mediated cross-talk between gastric cancer cells macrophages still remains unclear. Experimental Design: The expression CXCR2 its ligands 155 human tissues was analyzed via immunohistochemistry, correlations with clinical...
Abstract T cell exhaustion plays critical roles in tumor immune evasion. Novel strategies to suppress evasion are urgent need. We aimed identify potential compounds target and increase response checkpoint inhibitors (ICIs). Differentially expressed genes (DEGs) were identified between tumors with different by comparing the transcriptome data. DEGs then analyzed Connectivity Map (CMap) platform ICIs. Gene set enrichment analysis, LDH release assay, Chromatin immunoprecipitation (ChIP), Co-IP...
ZIP4 is overexpressed in human pancreatic cancer and promotes tumor growth. However, little known about the role of advanced stages this dismal neoplasm. Our goal to study underlying mechanism define a novel signaling pathway controlled by ZIP4-modulating metastasis.
Immune checkpoint inhibitors (ICIs) have achieved impressive success in a subset of malignant tumors. Tumor mutation burden (TMB), programmed cell death ligand 1 expression, and deficient DNA mismatch repair are the few biomarkers known to be associated with response ICIs. Breast cancer type or 2 susceptibility gene (BRCA1 [OMIM 113705] BRCA2 600185]) play critical roles repair. However, BRCA1/2 alteration tumor immunotherapy remains uncharacterized, our knowledge. Several early phase...
BackgroundN6-methyladenosine (m6A) is the most abundant mRNA modification. Whether m6A regulators can determine tumor aggressiveness and risk of immune evasion in pancreatic ductal adenocarcinoma (PDAC) remains unknown.MethodsAn integrated model named "m6Ascore" constructed based on RNA-seq data PDAC. Association m6Ascore overall survival validated across several different datasets. Overlaps established molecular classifications PDAC examined. Immune infiltration, enriched pathways, somatic...
Abstract Background Gastrointestinal cancers represent a major challenge to public health. Pancreatic cancer is the most lethal among all gastrointestinal cancers. Most patients cannot meet criteria of resection at diagnosis, indicating these will have dismal prognosis. Main text Neoadjuvant chemotherapy helps some regain opportunity radical resection. An optimal regimen one that maximizes anti-tumor efficacy while maintaining relatively manageable safety profile. The development surgical...
Immune escape is a major challenge in tumour immunotherapy. Pleckstrin-2(PLEK2) plays critical role progression, but its immune gastric cancer (GC) remains uncharacterized. RNA sequencing was used to explore the differentially expressed genes GC cell line that resistant antitumor effect of Natural killer (NK) cells. Apoptosis and expression IFN-γ TNF-α were detected by flow cytometry (FCM). PLEK2 examined Western blotting immunohistochemistry (IHC). upregulated MGC803R cells NK knockout...
Epidermal growth factor receptor (EGFR) is an essential target for cancer treatment. However, EGFR inhibitor erlotinib showed limited clinical benefit in pancreatic therapy. Here, we the underlying mechanism of tumor microenvironment suppressing sensitivity through stellate cell (PSC). The expression alpha-smooth muscle actin (α-SMA) and hypoxia marker human tissues were detected by immunohistochemistry, their correlation with overall survival was evaluated. Human immortalized PSC...
RNA-binding proteins (RBPs) play essential roles in tumorigenesis and progression, but their functions gastric cancer (GC) remain largely elusive. Here, it is reported that Pumilio 1 (PUM1), an RBP, induces metabolic reprogramming through post-transcriptional regulation of DEP domain-containing mammalian target rapamycin (mTOR)-interacting protein (DEPTOR) GC. In clinical samples, elevated expression PUM1 associated with recurrence, metastasis, poor survival. vitro vivo experiments...
Gastric cancer is one of the most lethal cancers worldwide. FYN, a gene that differentially expressed in gastric cancer, considered critical metastasis regulator several solid tumors, but its role still unclear. This study aimed to evaluate FYN and test whether promotes migration invasion cells vitro vivo via STAT3 signaling. was overexpressed positively correlated with metastasis. knockdown significantly decreased cell invasion, whereas overexpression increased invasion. Genetic inhibition...
Methylthioadenosine phosphorylase (MTAP) is a key enzyme associated with the salvage of methionine and adenine that deficient in 20% to 30% pancreatic cancer. Our previous study revealed MTAP deficiency indicates poor prognosis for patients ductal adenocarcinoma (PDAC). In this study, bioinformatics analysis The Cancer Genome Atlas (TCGA) data indicated PDACs display signature elevated glycolysis. Metabolomics studies showed deletion-mediated metabolic reprogramming enhanced glycolysis de...
Chemoresistance remains a major challenge in gastric cancer (GC). Chromodomain helicase DNA-binding protein 4 (CHD4) mediated chromatin remodeling plays critical roles various tumor types, but its role chemoresistance GC uncharacterized. CHD4 expression was examined by immunohistochemistry and Western blotting. The of on cell proliferation vitro vivo. Immunoprecipitation liquid chromatography-mass spectrometry were used to identify CHD4-binding proteins proximity ligation assay explore...
Background: Cachexia is a systemic disease manifested with muscle atrophy and appetite loss, especially in patients pancreatic cancer. Emerging evidence showed that cachexia an inflammation-associated disease. But the role of tumor immune microenvironment remains elusive. ZIP4, zinc transporter, plays critical promoting cancer cachexia. We aimed to study how ZIP4 promotes via interacting microenvironment. Methods: evaluated association between several major cell types tissue Genetically...
Glioblastoma (GBM) is the most aggressive form of brain cancer, with limited therapeutic options. While microglia contribute to GBM progression, mechanisms by which they foster a protumorigenic immune environment remain poorly understood. We identify zinc transporter Zrt- And Irt-Like Protein 4 (ZIP4) as pivotal regulator landscape. In orthotopic mouse models, ZIP4 drives tumor growth and behavioral changes. Mechanistically, modulates microglial plasticity through tumor-derived extracellular...