A5100678274- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Oral and Maxillofacial Pathology
- Ubiquitin and proteasome pathways
- Salivary Gland Tumors Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Biochemical and Molecular Research
- RNA modifications and cancer
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Mechanisms of cancer metastasis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Cell death mechanisms and regulation
- Pancreatic function and diabetes
Chinese Academy of Medical Sciences & Peking Union Medical College
2004-2025
Fudan University
2019-2024
Shanghai Cancer Institute
2018-2024
Fudan University Shanghai Cancer Center
2017-2024
Shanghai Medical College of Fudan University
2018-2024
Zhejiang Cancer Hospital
2024
Chinese Academy of Sciences
2015-2024
National Cancer Center
2017
Ruijin Hospital
2015
Shanghai Jiao Tong University
2003-2015
FBW7 functions as a tumor suppressor by targeting oncoproteins for degradation. Our previous study found was low expressed in pancreatic cancer due to sustained activation of Ras-Raf-MEK-ERK pathway, which destabilized phosphorylating at Thr205. MicroPET/CT imaging results revealed that substantially decreased 18F-fluorodeoxyglucose uptake xenograft tumors. Mechanistically, inhibited glucose metabolism via c-Myc/TXNIP axis. But these studies, we observed down-regulated genes were widely...
The epigenetic factor protein arginine methyltransferase 5 (PRMT5) has been reported to play vital roles in a wide range of cellular processes, such as gene transcription, genomic organization, differentiation and cell cycle control. However, its role pancreatic cancer remains unclear. Our study aimed investigate the PRMT5 prognosis progression explore underlying molecular mechanism.Real-time PCR, immunohistochemistry analysis dataset from Cancer Genome Atlas (TCGA) were performed expression...
Abstract Background There is no evidence supporting the feasibility of laparoscopic pancreaticoduodenectomy (LPD) compared to open pancreatoduodenectomy (OPD) following neoadjuvant chemotherapy (NACT) for pancreatic ductal adenocarcinoma (PDAC). Methods The clinical data consecutive patients with borderline resectable PDAC who received NACT and underwent either LPD or OPD between January 2020 December 2022 at Fudan University Shanghai Cancer Center was prospectively collected retrospectively...
// Wensheng Liu 1, 2 , Fei Yue 1 Minhua Zheng Angelica Merlot Dong-Hun Bae Michael Huang Darius Lane Patric Jansson Goldie Yuan Lam Vera Richardson Sumit Sahni Danuta Kalinowski Zaklina Kovacevic Des. R. Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School Medicine, 200025, P.R.China Molecular Pharmacology and Pathology Program, Bosch Institute, Blackburn Building (D06), Sydney, New South Wales 2006, Australia Correspondence to: Des Richardson, e-mail:...
Patients with pancreatic ductal adenocarcinoma have much worse prognoses, and effort has been directed toward understanding the molecular biological aspects of this disease. Accumulated evidence suggests that constitutive activation Wnt/β-catenin signalling contributes to oncogenesis progression cancer. Transcription factor 7-like2/transcription 4 (TCF7L2/TCF4), a β-catenin transcriptional partner, plays vital role in pathway. In present study, we investigated clinicopathological...
Accumulated evidence suggests that Pin1 contributes to oncogenesis of diverse cancers. However, the underlying mechanism oncogenic function in PDAC requires further exploration.IHC was performed using tissues. Western blot, PCR, immunofluorescence and transwell were cell lines. GSEA applied for possible downstream pathways. ChIP assay dual luciferase used assessment transcriptional activity.Both IL-18 levels are increased primary tissues their positively correlated. High expression is a...
// Xiongzhi Wangpu 1, 2, 3 , Xiao Yang 4 Jingkun Zhao 2 Jiaoyang Lu Shaopei Guan Jun Zaklina Kovacevic Wensheng Liu 1 Lan Mi Runsen Jin Jing Sun Fei Yue Junjun Ma Aiguo Des R. Richardson Lishun Wang 5 Minhua Zheng Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School Medicine, Shanghai, 200025, China Minimally Invasive Surgery Center, Molecular Pharmacology and Pathology Program, Bosch Institute, Sydney, New South Wales, 2006, Australia Institute Digestive The...
Abstract Objectives To investigate the roles of homeodomain‐interacting protein kinase (HIPK) family proteins in pancreatic cancer prognosis and possible molecular mechanism. Materials Methods The expression HIPK genes their were analysed by using Cancer Genome Atlas (TCGA). HIPK2 proliferation glycolysis tested overexpression cells, followed cell assay, glucose uptake analysis Seahorse extracellular flux analysis. mechanism action was explored examining its effect on ERK/cMyc axis. Results...
Methylthioadenosine phosphorylase (MTAP) is a key enzyme associated with the salvage of methionine and adenine that deficient in 20% to 30% pancreatic cancer. Our previous study revealed MTAP deficiency indicates poor prognosis for patients ductal adenocarcinoma (PDAC). In this study, bioinformatics analysis The Cancer Genome Atlas (TCGA) data indicated PDACs display signature elevated glycolysis. Metabolomics studies showed deletion-mediated metabolic reprogramming enhanced glycolysis de...
Background and objective: Sacituzumab govitecan (SG), the first antibody-drug conjugate targeting human trophoblast cell-surface antigen 2 (Trop-2), has been approved by Food Drug Administration (FDA) for treatment of advanced or metastatic breast cancer urothelial cancer. However, there is currently a dearth information regarding safety profiles SG in large sample cohort. The objective present study to investigate SG-related adverse events (AEs) real-world settings leveraging FDA Adverse...
Abstract Objectives Decreased deoxycytidine kinase ( dCK ) expression is a reported indicator of gemcitabine efficacy in pancreatic cancer, due to the impact this on metabolism. The transcription factor NF ‐E2 p45‐related 2 NRF 2, also called Nfe2l2), master regulator redox homoeostasis, has been tightly control numerous ROS ‐detoxification genes and participates drug resistance. However, contribution signalling axis seldom discussed needs investigation. Materials methods By overexpressing...
Hepatocyte nuclear factor 4α (HNF4α) is a tissue-specific transcription that regulates the expression of numerous genes in hepatocytes and pancreatic β cells. HNF4α has been reported to affect cell proliferation chemoresistance several cancers. However, role adenocarcinoma (PDAC) not studied extensively remains unclear. By utilizing immunohistochemical (IHC) staining, we measured PDAC tissues. silencing lines, assessed impact on cancer gemcitabine sensitivity. We used CCK8 colony formation...
Abstract Tubeimoside 1, one of the new triterpenoid saponins from bulb Bolbostemma paniculatum (Maxim) Franquet, had an anti‐inflammatory effect on mouse ear edema induced by arachidonic acid and 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA). Furthermore, a potent anti‐tumorigenic tubeimoside I was observed in 2‐stage carcinogenesis skin after oral administration as well topical application. Thus, appears to be promising agent for cancer chemoprevention.
Constitutive ERK1/2 activation has been frequently observed in pancreatic adenocarcinoma (PDAC). How status potentiated and maintained by epigenetic mechanisms seldom discussed PDAC. In this study, we first examined the expression of p-ERK1/2 PDAC tissues immunohistochemical staining then screened possible factors that displayed different between high low groups RNA profiling, found SETD8 an increased expressional pattern p-ERK1/2high patient group. Then impact on proliferation cells were...