A5101727201- Biochemical and Molecular Research
- Cancer, Hypoxia, and Metabolism
- Metabolism and Genetic Disorders
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Advancements in Battery Materials
- Conducting polymers and applications
- Perovskite Materials and Applications
- Advanced Battery Materials and Technologies
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Organic Light-Emitting Diodes Research
- Supramolecular Self-Assembly in Materials
- Telecommunications and Broadcasting Technologies
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Advanced Battery Technologies Research
- Nanocluster Synthesis and Applications
- Advanced battery technologies research
- Advanced MIMO Systems Optimization
- Immunotherapy and Immune Responses
- Evaluation Methods in Various Fields
- Cell Adhesion Molecules Research
- Cooperative Communication and Network Coding
Fudan University Shanghai Cancer Center
2019-2025
Jimei University
2024-2025
Wuhan Children's Hospital
2024
Huazhong University of Science and Technology
2024
Leiden University
2021-2024
Southwest University
2023-2024
Beijing Institute of Technology
2024
Tianjin University
2024
Shanghai Medical College of Fudan University
2020-2023
Shanghai Cancer Institute
2020-2023
FBW7 functions as a tumor suppressor by targeting oncoproteins for degradation. Our previous study found was low expressed in pancreatic cancer due to sustained activation of Ras-Raf-MEK-ERK pathway, which destabilized phosphorylating at Thr205. MicroPET/CT imaging results revealed that substantially decreased 18F-fluorodeoxyglucose uptake xenograft tumors. Mechanistically, inhibited glucose metabolism via c-Myc/TXNIP axis. But these studies, we observed down-regulated genes were widely...
Abstract Efficient cytosolic delivery of RNA molecules remains a formidable barrier for therapeutic strategies. Lipid nanoparticles (LNPs) serve as state-of-the-art carriers that can deliver intracellularly, exemplified by the recent implementation several vaccines against SARS-CoV-2. Using bottom-up rational design approach, we assemble LNPs contain programmable lipid phases encapsulating small interfering (siRNA). A combination cryogenic transmission electron microscopy, tomography and...
Ionizable cationic lipids (ICLs) play an essential role in the effectiveness of lipid nanoparticles (LNPs) for delivery mRNA therapeutics and vaccines; therefore, critical evaluations their biological performance would extend existing knowledge field. In present study, we examined effects three clinically-approved ICLs, Dlin-MC3-DMA, ALC-0315 SM-102, as well DODAP, on vitro vivo LNPs vaccine efficacy. mRNA-LNPs containing these were successfully prepared, which all found to be very similar...
The induction of a potent T cell response is essential for successful tumor immunotherapy and protection against many infectious diseases. In the past few years, mRNA vaccines have emerged as immune activators inducers robust response. recent approval Moderna Pfizer/BioNTech based on lipid nanoparticles (LNP) encapsulating antigen-encoding has revolutionized field vaccines. advantages LNPs are their ease design formulation resulting in potent, effective, safe However, there still plenty room...
Abstract Management of functional groups in hole transporting materials (HTMs) is a feasible strategy to improve perovskite solar cells (PSCs) efficiency. Therefore, starting from the carbazole–diphenylamine‐based JY7 molecule, JY8 and JY9 molecules are incorporated into different electron‐withdrawing fluorine cyano on side chains. The theoretical results reveal that introduction can these highest occupied molecular orbital (HOMO) energy levels, intermolecular stacking arrangements, stronger...
An ideal nanomedicine system improves the therapeutic efficacy of drugs. However, most nanomedicines enter cells via endosomal/lysosomal pathways and only a small fraction cargo enters cytosol inducing effects. To circumvent this inefficiency, alternative approaches are desired. Inspired by fusion machinery found in nature, synthetic lipidated peptide pair E4/K4 is used to induce membrane previously. Peptide K4 interacts specifically with E4, it has lipid affinity resulting remodeling....
Heart failure is a serious condition that results from the extensive loss of specialized cardiac muscle cells called cardiomyocytes (CMs), typically caused by myocardial infarction (MI). Messenger RNA (mRNA) therapeutics are emerging as very promising gene medicine for regenerative therapy. To date, lipid nanoparticles (LNPs) represent most clinically advanced mRNA delivery platform. Yet, their efficiency has been limited endosomal entrapment after endocytosis. Previously, we demonstrated...
Introducing 2D perovskite onto the surface of 3D could not only passivate defects in perovskite, but also protect from humidity invasion, which improve device stability. The choice spacer cations perovskites directly influences overall properties layer, is crucial to efficiency and stability devices. Herein, trifluoromethyl benzylamine developed as cation, effects –CF 3 at different substitution positions on morphology, carrier dynamics, performances are systematically investigated. Results...
Abstract Low‐temperature lithium‐sulfur batteries (LSBs) face challenges such as Li₂S accumulation and the slow conversion of lithium polysulfides (LiPSs), significantly affecting their capacity cycling life. While functionalizing cathode shows potential to overcome these problems, there has been little focus on understanding deposition behavior at low temperatures specific catalysis processes newly identified platforms. Here we report an island‐like Bi₂O₃ uniformly distributed reduced...
RNA therapeutics offer a promising approach to cancer treatment by precisely regulating cancer-related genes. While lipid nanoparticles (LNPs) are currently the most advanced nonviral clinically approved vectors for therapeutics, their antitumor efficacy is limited unspecific hepatic accumulation after systemic administration. Thus, there an urgent need enhance delivery efficiency of LNPs target tumor-residing tissues. Here, we conjugated cluster differentiation 44 (CD44)-specific targeting...
Endothelial cell migration is essential for tumor angiogenesis, and interleukin-8 (IL-8) has been shown to play an important role in growth, metastasis.This study aimed investigate the molecular mechanism of IL-8 induced endothelial migration.Our results indicated that a rapid rearrangement actin cytoskeleton EA.Hy926 cells, generating extensions resembling membrane ruffling stress fibers.These processes required parallel upregulation small GTPases Rac1 RhoA.Moreover, we demonstrated...
Methylthioadenosine phosphorylase (MTAP) is a key enzyme associated with the salvage of methionine and adenine that deficient in 20% to 30% pancreatic cancer. Our previous study revealed MTAP deficiency indicates poor prognosis for patients ductal adenocarcinoma (PDAC). In this study, bioinformatics analysis The Cancer Genome Atlas (TCGA) data indicated PDACs display signature elevated glycolysis. Metabolomics studies showed deletion-mediated metabolic reprogramming enhanced glycolysis de...
Several targeted drug delivery systems have recently been developed to increase the bioavailability of a at its site action, allowing simultaneous reduction total necessary dose as well side effects. Here, we designed cationic gene vector containing matrix metalloproteinase-2 (MMP2)-cleavable substrate peptides that specifically target tumor sites where MMP2 levels are high. The system is fabricated by linking enzyme-cleavable polyethylene glycol (PEG) derivatives...
Abstract Many drug delivery systems end up in the lysosome because they are built from covalent or kinetically inert supramolecular bonds. To reach other organelles, nanoparticles hence need to either be made a labile interaction that allows re‐assembly of inside cell following endocytic uptake, or, taken by mechanism short‐circuits classical endocytosis pathway. In this work, intracellular fate nanorods self‐assemble via Pt…Pt cyclometalated platinum(II) compounds, is studied. These...
Magnetic-activated cell sorting (MACS) is an affinity-based technique used to separate cells according the presence of specific markers. Current MACS systems generally require antigen be expressed at surface; these antigen-presenting subsequently interact with antibody-labeled magnetic particles, facilitating separation. Here, we present alternative method based on coiled-coil peptide interactions. We demonstrate that HeLa, CHO, and NIH3T3 can either incorporate a lipid-modified...
Constitutive ERK1/2 activation has been frequently observed in pancreatic adenocarcinoma (PDAC). How status potentiated and maintained by epigenetic mechanisms seldom discussed PDAC. In this study, we first examined the expression of p-ERK1/2 PDAC tissues immunohistochemical staining then screened possible factors that displayed different between high low groups RNA profiling, found SETD8 an increased expressional pattern p-ERK1/2high patient group. Then impact on proliferation cells were...