A5077493685- Lipid Membrane Structure and Behavior
- Electron Spin Resonance Studies
- Porphyrin and Phthalocyanine Chemistry
- Photochromic and Fluorescence Chemistry
- Magnetism in coordination complexes
- Lanthanide and Transition Metal Complexes
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Fuel Cells and Related Materials
- Graphene research and applications
- Nanopore and Nanochannel Transport Studies
- Metabolomics and Mass Spectrometry Studies
- Nanoparticle-Based Drug Delivery
Leiden University
2019-2024
Ionizable cationic lipids (ICLs) play an essential role in the effectiveness of lipid nanoparticles (LNPs) for delivery mRNA therapeutics and vaccines; therefore, critical evaluations their biological performance would extend existing knowledge field. In present study, we examined effects three clinically-approved ICLs, Dlin-MC3-DMA, ALC-0315 SM-102, as well DODAP, on vitro vivo LNPs vaccine efficacy. mRNA-LNPs containing these were successfully prepared, which all found to be very similar...
Lipid conjugates have advanced the field of lipid-based nanomedicine by promoting active-targeting (ligand, peptide, antibody), stability (PEGylation), controlled release (lipoid prodrug), and probe-based tracking (fluorophore). Recent findings indicate lipid dissociating from upon encountering a biological environment. Yet, implications for (pre)clinical outcomes remain unclear. In this study, using zebrafish model (Danio rerio), we investigated fate liposome-incorporated fluorophore (LFCs)...
Abstract Synthetic metal complexes can be used as paramagnetic probes for the study of proteins and protein complexes. Herein, two transition NMR (TraNPs) are reported. TraNPs attached through arms to a generate pseudocontact shift (PCS) using cobalt(II), or relaxation enhancement (PRE) with manganese(II). The PCS analysis three different shows that size anisotropic component magnetic susceptibility depends on probe surroundings at surface protein, contrary what is observed lanthanoid‐based...
<title>Abstract</title> An ideal proton exchange membrane should only permeate protons and be leak-tight for fuels. Graphene is impermeable to water poorly conducting protons. Next long-term stability an optimized therefore needs fulfil two main criteria: permeability selectivity. Within methanol fuel cells, the first ensures a high-power density, while second prevents cross-over between electrodes, which deteriorates catalyst performance and, thereby, drastically lowers performance....
The mobility of proteins in the bilayer membrane is affected by (local) changes lipid environment, which important to their biological functioning. Artificial molecular systems that – some extent imitate tasks membrane‐embedded are increasingly developed, however, they usually controlled through responsive units core structure. Here we present an alternative approach based on amphiphilic stiff‐stilbene derivative enables control fluidity light. increase upon E‐to‐Z isomerization shown...
The mobility of proteins in the bilayer membrane is affected by (local) changes lipid environment, which important to their biological functioning. Artificial molecular systems that - some extent imitate tasks membrane-embedded are increasingly developed, however, they usually controlled through responsive units core structure. Here we present an alternative approach based on amphiphilic stiff-stilbene derivative enables control fluidity light. increase upon E-to-Z isomerization shown...