A5080788837- Lipid Membrane Structure and Behavior
- Glycosylation and Glycoproteins Research
- Characterization and Applications of Magnetic Nanoparticles
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Spectroscopy and Quantum Chemical Studies
- Erythrocyte Function and Pathophysiology
- Lysosomal Storage Disorders Research
- Nanoparticle-Based Drug Delivery
- Metabolomics and Mass Spectrometry Studies
- Force Microscopy Techniques and Applications
Czech Academy of Sciences, J. Heyrovský Institute of Physical Chemistry
2021-2024
Charles University
2022-2023
Lipid conjugates have advanced the field of lipid-based nanomedicine by promoting active-targeting (ligand, peptide, antibody), stability (PEGylation), controlled release (lipoid prodrug), and probe-based tracking (fluorophore). Recent findings indicate lipid dissociating from upon encountering a biological environment. Yet, implications for (pre)clinical outcomes remain unclear. In this study, using zebrafish model (Danio rerio), we investigated fate liposome-incorporated fluorophore (LFCs)...
Gangliosides are important glycosphingolipids involved in a multitude of physiological functions. From physicochemical standpoint, this is related to their ability self-organize into nanoscopic domains, even at molar concentrations one per 1000 lipid molecules. Despite recent experimental and theoretical efforts suggesting that hydrogen bonding network crucial for nanodomain stability, the specific ganglioside moiety decisive development these nanodomains has not yet been identified. Here,...
Plasma membranes as well their simplified model systems show an inherent nanoscale heterogeneity. As a result of strong interleaflet interactions, these nanoheterogeneities (called here lipid nanodomains) can be found in perfect registration (i.e., nanodomains the inner leaflet are registered with outer leaflet). Alternatively, they might independent, antiregistered, or located asymmetrically one bilayer only. To distinguish scenarios from each other appears to experimental challenge. In...
ABSTRACT Plasma membranes as well their simplified model systems show an inherent nanoscale heterogeneity. As a result of strong interleaflet interactions, these nanoheterogeneities (called here lipid nanodomains) can be found in perfect registration ( i.e. nanodomains the inner leaflet are registered with outer leaflet). Alternatively, they might inter-leaflet independent, anti-registered or located asymmetrically one bilayer only. To distinguish scenarios from each other appears to...