A5100723783- RNA modifications and cancer
- Phytochemical compounds biological activities
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune cells in cancer
- Redox biology and oxidative stress
- Metal complexes synthesis and properties
- Plant biochemistry and biosynthesis
- DNA Repair Mechanisms
- Biosensors and Analytical Detection
- Legume Nitrogen Fixing Symbiosis
- PARP inhibition in cancer therapy
- Plant Gene Expression Analysis
- Plant nutrient uptake and metabolism
- Gastric Cancer Management and Outcomes
- Ovarian cancer diagnosis and treatment
- Multiple and Secondary Primary Cancers
- Extracellular vesicles in disease
- Phytochemical Studies and Bioactivities
- Genomics, phytochemicals, and oxidative stress
- Stochastic Gradient Optimization Techniques
- Ferrocene Chemistry and Applications
- Cancer Mechanisms and Therapy
Zhujiang Hospital
2023-2025
Southern Medical University
2023-2025
Nanjing Agricultural University
2019-2025
Guangxi Medical University
2023-2024
Chinese University of Hong Kong
2019-2024
Lanzhou University
2006-2024
University of Macau
2023
The Seventh Affiliated Hospital of Sun Yat-sen University
2019-2022
Sun Yat-sen University
2019-2022
The People's Hospital of Guangxi Zhuang Autonomous Region
2015-2021
Abstract Background N6‐methyladenosine (m6A) methylation, a well‐known modification with new epigenetic functions, has been reported to participate in gastric cancer (GC) tumourigenesis, providing novel insights into the molecular pathogenesis of GC. However, involvement Wilms’ tumour 1‐associated protein (WTAP), key component m6A GC progression is controversial. Here, we investigated biological role and underlying mechanism WTAP Methods We determined expression using tissue microarrays The...
Abstract N6‐methyladenosine (m6A) is a well‐known modification of RNA. However, as key m6A methyltransferase, METTL16 has not been thoroughly studied in gastric cancer (GC). Here, the biological role GC and its underlying mechanism was studied. Immunohistochemistry used to detect expression relationship between level prognosis analysed. CCK8, colony formation assay, EdU assay xenograft mouse model were study effect METTL16. Regulatory progression through flow cytometry analysis, RNA...
Plants that grow in extreme environments represent unique sources of stress-resistance genes and mechanisms. Ammopiptanthus mongolicus (Leguminosae) is a xerophytic evergreen broadleaf shrub native to semi-arid desert regions; however, its drought-tolerance mechanisms remain poorly understood. Here, we report the assembly reference-grade genome for A. mongolicus, describe evolutionary history within legume family, examine The assembled 843.07 Mb length, with 98.7% sequences successfully...
Abstract The anthocyanin content in apple skin determines its red coloration, as seen a Fuji mutant. Comparative RNA-seq analysis was performed to determine differentially expressed genes at different fruit development stages between the wild-type and color A novel R2R3-MYB transcription factor, MdMYB90-like, uncovered key regulatory gene for enhanced coloration expression of MdMYB90-like 21.3 times higher regulates biosynthesis directly through activation indirectly other factors that...
Unprogrammed macrophage polarization, especially prolonged activation of proinflammatory macrophages, is associated with delayed wound healing in diabetic objectives. Macrophage-derived exosomes cargo a variety microRNAs (miRNAs), participating different stages healing. Here, were isolated from naive bone marrow-derived macrophages (BMDMs) (M0-Exos), interferon-γ plus lipopolysaccharide-polarized BMDMs (M1-Exos), and interleukin-4-polarized (M2-Exos). M1-Exos impaired migration tube...
Pentatricopeptide repeat (PPR) proteins constitute one of the largest protein families in land plants. Recent studies revealed functions PPR organellar RNA metabolism and plant development, but most proteins, especially PPRs localized nucleus, remain largely unknown. Here, we report isolation characterization a rice mutant named floury growth retardation1 (fgr1). fgr1 showed endosperm with loosely arranged starch grains, decreased amylose contents, retarded seedling growth. Map-based cloning...
To evaluate the prognostic and molecular mechanisms of sex racial differences in gastric cancer, data from two large centers were used to retrospectively analyze survival cancer patients with regard differences. In examining mechanism different races, The Cancer Genome Atlas database differentially expressed genes (DEGs), Gene Ontology (GO) enrichment DNA methylation analyses performed. Among White patients, it was found that prognosis for females better than males; conversely, among Chinese...
In the process of epithelial-mesenchymal transition (EMT), epithelial cancer cells transdifferentiate into mesenchymal-like with high motility and aggressiveness, resulting in spread tumor cells. Immune inflammation microenvironment are driving factors EMT, but few studies have explored core targets interaction between EMT immune We analyzed thousands cases gastric tissue specimens TCGA, CPTAC, GTEx analyzing QPCR IHC data 56 patients SYSU Gastric Cancer Research Center. It was known that...
In recent years, triple therapy (molecular targeted agent + PD-1 inhibitor transarterial therapy) has emerged as a promising strategy for unresectable hepatocellular carcinoma (uHCC). However, the optimal molecular choice within remains unclear. Donafenib is currently only drug with superior survival benefits compared sorafenib monotherapy. This study aimed to compare donafenib-based versus sorafenib-based in patients uHCC, providing preliminary evidence guide selection this emerging...
Background: N6-methyladenosine (m6A) modification plays a crucial role in the progression of various cancers, including pancreatic cancer, by regulating gene expression. However, specific mechanisms which m6A affects cancer metastasis remain unclear. This study aims to elucidate METTL16, an writer gene, core genes such as CAPN2 and MROH8, influencing tumor growth metastasis. Materials methods: Transcriptomic data from patients The Cancer Genome Atlas (TCGA) were analyzed identify m6A-related...
ABSTRACT Nitric oxide (NO) is a vital immune molecule eliciting resistance to diverse microbial pathogens in humans and animals. However, its functional integration into plant networks remains incompletely characterized. In this study, we reveal that both endogenous induction exogenous supplementation of NO significantly enhance rice stripe virus (RSV), Bunyavirus poses huge threat production. The nitrate transporter OsNPF6.1 potentiates by upregulating the expression reductase ( OsNR2 )...
Gastric cancer (GC) is the third leading cause of deaths worldwide.Conventional chemotherapy has been proven useful to only a portion patients.Previous developed targeted drugs are more effective and tolerable than conventional drugs.Thus development novel targeting markers an urgent task main direction for future research.Ethaselen, inhibitor thioredoxin reductase (TrxR), considered important anticancer target drug.Previous studies show that it on treating many kinds cancers.In this paper,...
Polyphyllin VII, a compound extracted from the rhizomes of Paris polyphylla, has strong antitumor effects on various human tumor cell lines. However, few studies have reported possible effect VII osteosarcoma (OS) The present study revealed that promoted OS apoptosis and inhibited proliferation via upregulating expression LC3II, Atg5, Atg7 Atg12‑Atg5 complex. By contrast, treatment cells with downregulated Atg12 p62 expression. Following class III PI 3‑kinase inhibitor (3‑MA; an autophagy...
Ten new tirucallane-type triterpenoids, represented by a rearranged skeleton dysolenticin A (1), B (2), rare trinortriterpenoid C (3), three tirucallane triterpenoid derivatives with hemiketal moiety dysolenticins D–F (4–6), G–I (7, 9, 10), and the alkaloid J (12), together seven known analogues were isolated from twigs leaves of Dysoxylum lenticellatum. Their structures elucidated extensive spectroscopic methods, those compounds 1, 3, 4, 6, 10 confirmed single-crystal X-ray diffraction...
Chemotherapy plays an irreplaceable role in the treatment of GC, but currently available chemotherapeutic drugs are not ideal.The application medicinal plants is important direction for new drug discovery.Through screening GC organoids, we determined that ailanthone has anticancer effect on cells vitro and vivo.We also found AIL can induce DNA damage apoptosis cells.Further transcriptome sequencing PDX tissue indicated inhibited expression XRCC1, which repair, results were confirmed by...
Oxaliplatin (OXA) resistance in the treatment of different types cancer is an important and complex problem. The culture tumor organoids derived from gastric can help us to provide a deeper understanding underlying mechanisms that lead OXA resistance. In this study, our purpose was understand resistance, survival benefits patients with through targeted combination therapies. Using sequence analysis OXA-resistant non-OXA-resistant organoids, we found PARP1 gene mediates Through patients’...
Abstract In our previous research, we proved that ailanthone (AIL) inhibits the growth of gastric cancer (GC) cells and causes apoptosis by inhibiting P23. However, still find some GC organoids are insensitive to AIL. We have done sequencing analysis found strains highly expressed in PARP1. this study, investigated whether AIL can enhance anti‐tumour effect PARPi GC. CCK8 spheroid colony formation assay were used measure effects. SynergyFinder software was calculate synergy score drug...
Abstract The effects of increased intraspecific competition on size hierarchies (size inequality) and reproductive allocation were investigated in populations the annual plant, spring wheat ( Triticum aestivum) . A series densities (100, 300, 1 000, 3 000 10 plants/m 2 ) along a gradient intensity designed this experiment. results showed that average shoot biomass decreased with density. Reproductive was negatively correlated to Gini coefficient R = 0.927), which suggested is inclined...
Abstract A simple and rapid electrochemical sensing method with high sensitivity specificity of aptamers was developed for the detection methylamphetamine (MAMP). short anti-MAMP thiolated aptamer (Apt) a methylene blue (MB) probe at 3ʹ-end immobilized on surface gold electrode (MB-Apt-S/GE). The signal appeared when MAMP presenting in sample solution competed cDNA binding MB-Apt-S. Under optimized conditions, liner range this signal-on aptasensor achieved from 1.0 to 10.0 nmol/L 10.0–400...
Abstract Monocultures of spring wheat (Triticum aestivum L.) were grown at overcrowded densities (10 000 and 3 plants per m 2 ) under well‐watered water‐stressed conditions to investigate the effects water deficits on self‐thinning. The results showed that density reduction in populations was delayed compared with populations. Populations conformed ‐3/2‐power law. Compared condition, there no significant decrease self‐thinning line underwater‐stressed this experiment, although rate average...