A5050502418- Reproductive Physiology in Livestock
- Reproductive Biology and Fertility
- Genetic and phenotypic traits in livestock
- Ruminant Nutrition and Digestive Physiology
- Paraoxonase enzyme and polymorphisms
- Growth Hormone and Insulin-like Growth Factors
- MicroRNA in disease regulation
- Sperm and Testicular Function
- Effects of Environmental Stressors on Livestock
- Cynara cardunculus studies
- Genetics, Aging, and Longevity in Model Organisms
- Animal health and immunology
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Telomeres, Telomerase, and Senescence
- Circular RNAs in diseases
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Circadian rhythm and melatonin
- Ovarian function and disorders
- Endometriosis Research and Treatment
- Diet and metabolism studies
- RNA modifications and cancer
- RNA Research and Splicing
- Apelin-related biomedical research
Universidade Federal de Pelotas
2016-2025
Instituto Federal Catarinense
2021
University of Central Florida
2016-2019
Cornell University
2014-2017
Fundação de Estudo e Pesquisa em Medicina Veterinária e Zootecnia
2017
Universidade Estadual do Rio Grande do Sul
2015
Hy-Line (United States)
2007-2008
Swiss Tropical and Public Health Institute
2002
Purdue University West Lafayette
1955
Cellular senescence contributes to age-related disorders including physical dysfunction, disabilities, and mortality caused by tissue inflammation damage. Senescent cells accumulate in multiple tissues with aging at etiological sites of chronic disorders. The senolytic drug combination, Dasatinib plus Quercetin (D+Q), is known reduce senescent cell abundance aged mice. However, the effects long-term D+Q treatment on intestinal inflammatory burden microbiome composition mice remain unknown....
Abstract Ovarian aging leads to diminished fertility, dysregulated endocrine signaling and increased chronic disease burden. These effects begin emerge long before follicular exhaustion. Female humans experience a sharp decline in fertility around 35 years of age, which corresponds declines oocyte quality. Despite growing body work, the field lacks comprehensive cellular map transcriptomic changes mouse ovary identify early drivers ovarian decline. To fill this gap we performed single-cell...
The female reproductive tract (FRT) undergoes extensive remodeling during cycling. This recurrent and how it shapes organ-specific aging remains poorly explored. Using single-cell spatial transcriptomics, we systematically characterized morphological gene expression changes occurring in ovary, oviduct, uterus, cervix, vagina at each phase of the mouse estrous cycle, decidualization, into aging. These analyses reveal that fibroblasts play central-and highly organ-specific-roles FRT by...
Head and neck cancer is characterized by malignant tumors arising from the epithelium covering upper aerodigestive tract, majority of these epithelial malignancies are squamous cell carcinomas (SCCs) oral cavity (OSCCs). The aim current work was to identify miRNAs regulated in OSCC cancerous tissue when compared a healthy adjacent verify presence same circulation patients. For that serum samples biopsies tumor tissues were collected five patients diagnosed with cavity, RNA extracted...
The uterine fibrosis contributes to gestational outcomes. Collagen deposition in the uterus is related aging. Senolytic therapies are an option for reducing health complications We investigated effects of aging and senolytic drug combination dasatinib plus quercetin (D+Q) on fibrosis. Forty mice, 20 young females (03-months) old (18-months), were analyzed. Young (Y) (O) animals divided into groups 10 with one treatment (T) group (YT OT) another control © (YC OC). Comparative analysis...
Recent studies have demonstrated the remarkable potential of early life intervention strategies at influencing course postnatal development, thereby offering exciting possibilities for enhancing longevity and improving overall health. Metformin (MF), an FDA-approved medication type II diabetes mellitus, has recently gained attention its promising anti-aging properties, acting as a calorie restriction mimetic, delaying precocious puberty. Additionally, trodusquemine (MSI-1436),...
The objective of this study was to determine the effects uterine and systemic inflammatory responses bacterial contamination at calving in dairy cows on growth ovulatory outcomes first dominant follicle postpartum. Ovulatory capability postpartum predicted 53 multiparous by using a combination characteristics circulating estradiol concentrations. Endotoxin levels were assayed follicular fluid samples that aspirated day after outcome prediction. Plasma haptoglobin, proinflammatory acute phase...
Colorectal cancer is recognized as the fourth leading cause of cancer-related deaths worldwide. Thus, there ongoing search for potential new biomarkers allowing quicker and less invasive detection disease prediction treatment outcome. Therefore, aim our study was to identify colorectal specific miRNAs expressed in cancerous healthy tissue from same patient further correlate presence circulation diagnosis. In current we detected a set 40 differentially regulated tumor when comparing with...
MUCH controversy has occurred during the past few years regarding effect of restricted feeding upon various genetically influenced characters fowl. The position those supporting program is that it slows rate sexual maturity, allowing birds to develop a larger body size, in turn resulting initial and maintained egg weight. It further contended reduces adult mortality increases production. If these claims are true, use would not only increase returns from flock but also result considerable...