A5068641229- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Diet and metabolism studies
- Gut microbiota and health
- Histone Deacetylase Inhibitors Research
- Autophagy in Disease and Therapy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Wound Healing and Treatments
- Cancer therapeutics and mechanisms
- Cancer Immunotherapy and Biomarkers
- Exercise and Physiological Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Ubiquitin and proteasome pathways
- Lung Cancer Research Studies
- DNA and Nucleic Acid Chemistry
- Polyomavirus and related diseases
- Planarian Biology and Electrostimulation
- Vagus Nerve Stimulation Research
- Tryptophan and brain disorders
- Pressure Ulcer Prevention and Management
- Diabetes and associated disorders
- Long-Term Effects of COVID-19
- Gastrointestinal motility and disorders
University of Central Florida
2024-2025
Florida College
2025
Indian Institute of Chemical Biology
2019-2025
Council of Scientific and Industrial Research
2020-2022
Institute of Nuclear Medicine & Allied Sciences
2019
Abstract Background and Purpose Chemoresistance tumour relapse pose significant challenges in achieving successful chemotherapy outcomes. Targeting DNA polymerase eta (Pol ƞ)‐mediated mutagenic translesion synthesis (TLS) has emerged as a promising strategy for improving chemotherapy. However, the identification of small molecule inhibitors targeting Pol ƞ ‐ mediated TLS with high vivo efficacy remains challenge. Experimental Approach The was identified through silico screening. η inhibitory...
Sildenafil Citrate (SC) is a US FDA approved drug, have been used to treat wounds due their nitric oxide (NO) stimulating activity in the tissue. But, there are only few studies about topical effect of this drug on healing traumatic wounds. The purpose study develop SC hydrogel (SCH) and investigate its dermal toxicity wound efficacy Sprague dawley rats. In present study, containing showed no change stable with respect pH, homogeneity, spreadability effiecient encapsulation. SEM analysis...
USP30, a deubiquitinating enzyme family, forfeits the ubiquitination of E3 ligase and Parkin on surface mitochondria. Inhibition USP30 results in mitophagy cellular clearance. Herein, by understanding structural requirements, we discovered potential inhibitors from an imidazole series ligands via validated ubiquitin-rhodamine-110 fluorometric assay. A novel catalytic use Zn(l-proline)2 complex for synthesis tetrasubstituted imidazoles was identified. Among all compounds investigated, 3g 3f...
Background: Pembrolizumab has recently emerged as a PD-1 blockade immunotherapy treatment for lung cancer. It is critical that such strategies cancer should be chosen not only on the basis of histopathological features and expression targetable cell surface proteins (such PD-1), but rather selected based other determinants success or risk factors poor prognosis. One method to forecast trajectory identification biomolecular signatures microRNAs (miRNAs), non-protein-coding RNA molecules play...
Abstract Muscle wasting is a significant hurdle in patients due to immobilization, prolonged bed rest, and injury. In particular, the older population develops sarcopenia, characterized by progressive loss of muscle strength natural aging. However, there are no FDA-approved drugs for it critical explore novel therapeutics. Myostatin inhibition one such strategy that has had varying degrees success previously, yet desired levels have not been achieved. Here, we employed vaccine (V13)...
Abstract Chemoresistance and tumor relapse pose significant challenges in achieving successful chemotherapy outcomes. Targeting DNA polymerase eta (Pol ƞ) mediated-mutagenic translesion synthesis (TLS) has emerged as a promising strategy for improving chemotherapy. However, the identification of small molecule inhibitors specifically targeting Pol η - mediated TLS with high vivo efficacy remains challenge. In this study, we screened identified chrysin small-molecule inhibitor that sensitizes...
Abstract Pulmonary fibrosis is the major manifestation of idiopathic interstitial pneumonia as well post-COVID-19 complications. The pathogenesis PF a complex molecular process that involves many types cells, proteins, genes, and regulatory elements. non-coding RNA main element in this which mainly includes; miRNA, circRNA, lncRNA. These elements control expression important genes various pathways are involved pulmonary fibrosis. Identification mechanisms by these molecules works very...