A5101873811- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Chronic Myeloid Leukemia Treatments
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Chronic Lymphocytic Leukemia Research
- DNA Repair Mechanisms
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Vitamin D Research Studies
- Polyomavirus and related diseases
- BRCA gene mutations in cancer
- Pharmaceutical studies and practices
- Endoplasmic Reticulum Stress and Disease
All India Institute of Medical Sciences
2017-2024
DR. B.R.A. Institute Rotary Cancer Hospital
2020-2024
All India Institute of Medical Sciences Bhopal
2020-2024
All India Institute of Medical Sciences Raipur
2019-2024
All India Institute of Medical Sciences Rishikesh
2024
Sony Corporation (United States)
2023
Chandra Shekhar Azad University of Agriculture and Technology
2023
Gautam Buddha University
2022
Jinnah Postgraduate Medical Center
2021
Dow University of Health Sciences
2021
Background: The World Health Organization has recognized India as one of the nations with highest prevalence lifestyle sickness. It is quickly becoming capital lifestyle-related diseases due to starvation and a shortage food, which are main issues in developing countries like India. Studies suggest that significant proportion Indians, ranging from 4% 26%, living both rural urban areas, irrespective their age, may not have access sufficient amounts protein, calcium, other essential vitamins....
Acute lymphoblastic leukemia (ALL) is the most common pediatric hematological malignancy, with ETV6::RUNX1 being prevalent translocation whose exact pathogenesis remains unclear. IGF2BP1 (Insulin-like Growth Factor 2 Binding Protein 1) an oncofetal RNA binding protein seen to be specifically overexpressed in positive B-ALL. In this study, we have studied mechanistic role of leukemogenesis and its synergism fusion protein.
Breast cancer (BC) has emerged as the most common malignancy among females. The genomic profile of BC is diverse in nature and complex due to heterogeneity various geographically different ethnic groups. primary objective this study was carry out a comprehensive mutational analysis Indian cases by performing whole exome sequencing. cohort included patients with median age 48 years. TTN, TP53, MUC16, SYNE1, OBSCN were frequently altered genes found our cohort. PIK3CA KLC3 are driver...
Classical Non-Homologous End Joining (NHEJ) pathway is the mainstay of cellular response to DNA double strand breaks. While aberrant expression genes involved in this has been linked with genomic instability and drug resistance several cancers, limited information available about its clinical significance colon cancer. We performed a comprehensive analysis seven essential genes, including XRCC5, XRCC6, PRKDC, LIG4, XRCC4, NHEJ1 PAXX pathway, cancer using multi-omics datasets, studied their...
Glucocorticoid (GC), such as prednisolone, is an essential component of multidrug chemotherapy regimen for pediatric acute lymphoblastic leukemia (ALL). Resistance to GC in cells associated with disease progression and poor prognosis. Despite the extensive use many years, molecular mechanisms underlying its resistance ALL have not been fully uncovered. Recent studies shown a potential role EMP1, CASP1, NLRP3 genes prednisolone response. In this study on 148 B-ALL patients, we studied these...
Abstract T-acute lymphoblastic leukemia (T-ALL) is a heterogeneous malignancy characterized by the abnormal proliferation of immature T-cell precursors. Despite advances in immunophenotypic classification, understanding molecular landscape and its impact on patient prognosis remains challenging. In this study, we conducted comprehensive RNA sequencing cohort 35 patients with T-ALL to unravel intricate transcriptomic profile. Subsequently, validated prognostic relevance 23 targets,...
Melanoma associated antigen (MAGE) is an extensively studied family of tumor-associated genes that share a common MAGE homology domain (MHD). Based upon their expression pattern, have been broadly classified into type 1 MAGEs (T1Ms) and 2 (T2Ms) categories. Interestingly, several T2Ms are highly expressed in the brain involved regulation neuronal development, differentiation, survival. Available literature suggests possible tumor suppressor functions few T2Ms, while information available...
Around 85% of childhood Acute Lymphoblastic Leukemia (ALL) are B-cell origin and characterized by the presence different translocations including BCR-ABL1 , ETV6-RUNX1 E2A-PBX1 MLL fusion proteins. The current clinical investigations used to identify translocation include FISH transcript specific PCR. In study we assessed utility IGF2BP1 an oncofetal RNA binding protein, that is over expressed specifically in positive B-ALL be as a diagnostic marker clinic. Further, public transcriptomic...
A major issue in agriculture is the protection of crops against diseases and pests. Plant breeding has been primarily responsible for growth disease-resistant cultivars. The use gene editing techniques plant essential obtaining desired features. Clustered Regular Interspaced Palindromic Repeats (CRISPER)/Cas9 (CRISPR-related protein) a new advancement technology. It can be utilised defence mechanisms pathogen attack by recognising bacterial immune system destroying invasive genes. Advances...
Hepatocellular carcinoma (HCC) is an aggressive gastrointestinal malignancy with a high rate of mortality. Multiple studies have individually recognized members RAP gene family as critical regulators tumor progression in several cancers, including hepatocellular carcinoma. These suffer numerous limitations small sample size and lack analysis various clinicopathological molecular features. In the current study, we utilized authoritative multi-omics databases to determine association...
T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease, characterized by an abnormal transformation of T cells into highly proliferative leukemic lymphoblasts. Identification common genetic alterations has provided promising opportunities for better risk stratification in T-ALL. Current treatment T-ALL still poses the major challenge integrating knowledge molecular clinical setting. We utilized Multiplex Ligation Dependent Probe Amplification (MLPA) method to...
Resistance to therapy in esophageal squamous cell carcinoma (ESCC) is a critical clinical problem and identification of novel therapeutic targets highly warranted. Dipeptidyl peptidase III (DPP3) zinc-dependent aminopeptidase functions the terminal stages protein turnover. Several studies have reported overexpression oncogenic DPP3 numerous malignancies. The present study aimed determine expression pattern functional role ESCC. was assessed normal tumor tissues using quantitative real-time...
Acute myeloid leukemia with normal cytogenetics (CN-AML) represents a heterogeneous group having diverse genetic mutations. Understanding the significance of each these mutations is necessary. In this study, we evaluated prognostic role MN1 expression in adult CN-AML patients.
Introduction Tuberculous meningitis (TBM) brings significant morbidity and mortality worldwide. Hyponatremia has long been documented as a potentially grave metabolic result of TBM. The syndrome inappropriate antidiuretic hormone (SIADH) secretion supposed to be accountable for the majority cases hyponatremia in Cerebral salt wasting (CSWS) is being progressively reported basis some these cases. Differentiating CSWS from SIADH can challenging but vital because treatment two conditions...
Measurable/minimal residual disease (MRD) is considered the single most powerful high-risk factor in acute leukemia, including T-cell lymphoblastic leukemia (T-ALL). In this study, we evaluated impact of flow cytometry (FC)-based detection MRD on survival outcomes pediatrics, adolescents, and young adults (AYA) with T-ALL.
The molecular heterogeneity of T-cell acute lymphoblastic leukemia (T-ALL) makes this disease complex. Early precursor ALL (ETP-ALL) is a recognized subtype T-ALL associated with high probability induction failure conventional therapy. Higher expression myocyte enhancer factor 2C (MEF2C) and the absence biallelic deletion (ABD) are designated markers for ETP-ALL. Co-deletion contiguous genes cyclin-dependent kinase inhibitor 2A/2B (CDKN2A/2B) methylthioadenosine phosphorylase (MTAP) cluster,...