A5046795867- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Enzyme Structure and Function
- Retinal Diseases and Treatments
- PARP inhibition in cancer therapy
- Acute Lymphoblastic Leukemia research
- COVID-19 Clinical Research Studies
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Sexual Differentiation and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Synthesis and biological activity
- Microtubule and mitosis dynamics
- Electron Spin Resonance Studies
- Monoclonal and Polyclonal Antibodies Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Biochemical and Molecular Research
- Telomeres, Telomerase, and Senescence
- Adenosine and Purinergic Signaling
- Genetics, Aging, and Longevity in Model Organisms
- Mathematical Biology Tumor Growth
- Andrographolide Research and Applications
- Macrophage Migration Inhibitory Factor
- Advanced Nanomaterials in Catalysis
- Genomic variations and chromosomal abnormalities
Gautam Buddha University
2015-2024
DR. B.R.A. Institute Rotary Cancer Hospital
2022
All India Institute of Medical Sciences
2022
Indian Institute of Science Bangalore
2016
Bangalore University
2016
Chonnam National University
2009-2010
SARS-CoV-2 is causative agent of COVID-19, which responsible for severe social and economic disruption globally. Lack vaccine or antiviral drug with clinical efficacy suggested that repurposing approach may provide a quick therapeutic solution to COVID-19. Nonstructural protein-15 (NSP15) encodes an uridylate-specific endoribonuclease (EndoU) enzyme, essential virus life cycle attractive target development. We have performed in silico based virtual screening FDA approved compounds targeting...
With the progress in two distinct areas of nanotechnology and aptamer identification technologies, fields have merged to what is known as nanotechnology. Aptamers varying properties biomedical field include their small size, non-toxicity, ease manufacturing, negligible immunogenicity, ability identify a wide range targets, high immobilizing capacity. Nevertheless, aptamers can utilize characteristics offered by nanomaterials like optical, magnetic, thermal, electronic become more versatile...
Schistosomiasis, a neglected tropical disease, is leading cause of mortality in affected geographic areas. Currently, because no vaccine for schistosomiasis available, control measures rely on widespread administration the drug praziquantel (PZQ). The mass PZQ has prompted concerns regarding emergence resistance. Therefore, new therapeutic targets and potential compounds are necessary to combat schistosomiasis.
The novel Coronavirus disease 2019 (COVID-19) is potentially fatal and caused by Severe Acute Respiratory Syndrome 2 (SARS-CoV-2). Due to the unavailability of any proven treatment or vaccination, outbreak COVID-19 wreaking havoc worldwide. Hence, there an urgent need for therapeutics targeting SARS-CoV-2. Since, botanicals are important resource several efficacious antiviral agents, natural compounds gaining significant attention treatment. In present study, methyltranferase (MTase)...
Antimicrobial resistance (AMR) threatens global health with rising antibiotic-resistant infections, requiring novel antimicrobial targets. Therefore, it is of interest to report the molecular modeling and docking analysis TrmB from Pseudomonas aeruginosa suitable compounds. We show two compounds (5136 9865603) chemical library have optimal binding modelled for further consideration.
Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV2) is responsible for fetal pneumonia called COVID19. SARS-CoV2 emerged in Wuhan, Hubei Province of China December 2019. The COVID19 pandemic has now gripped the entire world with more than 70 million cases and over 1.5 deaths so far. There no treatment option term a drug or vaccine currently available. Therefore repurposing may only provide quick method utilizing existing drugs therapeutic option. virus genome contains several...
Poly(ADP-ribose) polymerase (PARP) is a critical nuclear enzyme which helps in DNA repair. In this study we report, synthesis and biological studies of novel pyridazine derivatives as PARP inhibitors.
In recent years, the outbreak of infectious disease caused by Zika Virus (ZIKV) has posed a major threat to global public health, calling for development therapeutics treat ZIKV disease. Several possible druggable targets involved in virus replication have been identified. search additional potential inhibitors, we screened 2895 FDA-approved compounds using Non-Structural Protein 5 (NS5) as target utilizing virtual screening in-silco methods. The top 28 with threshold binding energy -7.2...
Protein kinases are the family of attractive enzyme targets for drug design with relevance to cancer biology. Serine arginine protein kinase 1 (SRPK1) is responsible phosphorylation serine/arginine (SR)-rich proteins. Alternative Splicing Factor/Splicing Factor 2 (ASF/SF2) involved in mRNA editing. ASF/SF2 over expressed many cancers and plays crucial roles cell survival. Phosphorylation decisive its functions cancer. In search potential anticancer therapeutic agents attenuating ASF/SF2, we...
Pyridoxal kinase (PDXK) is a vitamin B6-dependent transferase enzyme encoded by the
Serine-arginine protein kinase-1 (SRPK1) is a highly specific kinase that recognizes serine-arginine dipeptide repeats and phosphorylates SR rich splicing factor ASF/SF2 in cell-cycle regulated manner. SRPK1 processively serine residues on its substrate ASF/SF2. Elevated expression pattern of both their association with various carcinomas have established as potent target for drug design against cancers. In order to develop inhibitors the binding desired be selectively interrupted. We...
A leucine-rich protein, ARR19 (androgen receptor corepressor-19 kDa), is highly expressed in male reproductive organs and moderately others. Previously, we have reported that differentially adult Leydig cells during the testis development inhibits steroidogenesis by reducing expression of steroidogenic enzymes. Whereas prostate, represses transcriptional activity AR receptor), it important for sexual differentiation maturation prostate epididymis, through recruitment HDAC4. In this study...
T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease, characterized by an abnormal transformation of T cells into highly proliferative leukemic lymphoblasts. Identification common genetic alterations has provided promising opportunities for better risk stratification in T-ALL. Current treatment T-ALL still poses the major challenge integrating knowledge molecular clinical setting. We utilized Multiplex Ligation Dependent Probe Amplification (MLPA) method to...
Coronavirus belongs to the coronaviridae family, having a single-stranded RNA as genetic material of 26-42 kb in size. The first coronavirus infection emerged 2002, caused by SARS-CoV1. Since then, genome sequences and three-dimensional structures crucial proteins enzymes virus have been studied detail. novel (nCoV) outbreak has COVID19 pandemic, which is responsible for deaths millions people worldwide. nCoV was later renamed SARS-CoV2. details most COV are available at atomic molecular...