A5090127084- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Tryptophan and brain disorders
- Attention Deficit Hyperactivity Disorder
- Autism Spectrum Disorder Research
- Chronic Myeloid Leukemia Treatments
- Genetics and Neurodevelopmental Disorders
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Animal Diversity and Health Studies
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Milk Quality and Mastitis in Dairy Cows
- Childhood Cancer Survivors' Quality of Life
- Livestock Management and Performance Improvement
- Chronic Lymphocytic Leukemia Research
- Bipolar Disorder and Treatment
- Animal health and immunology
- Genetically Modified Organisms Research
- Erythrocyte Function and Pathophysiology
- Congenital heart defects research
- Computational Drug Discovery Methods
- Blood transfusion and management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Johns Hopkins University
2023-2025
Sidney Kimmel Comprehensive Cancer Center
2024-2025
All India Institute of Medical Sciences
2014-2024
Johns Hopkins Medicine
2024
All India Institute of Medical Sciences Bhopal
2019-2024
All India Institute of Medical Sciences Raipur
2019-2024
University of Baltimore
2023
DR. B.R.A. Institute Rotary Cancer Hospital
2014-2021
Desh Bhagat Ayurvedic College and Hospital
2021
Manovikas Kendra Rehabilitation and Research Institute
2013-2020
Cancer persists as a global challenge necessitating continual innovation in treatment strategies. Despite significant advancements comprehending the disease, cancer remains leading cause of mortality worldwide, exerting substantial economic burdens on healthcare systems and societies. The emergence drug resistance further complicates therapeutic efficacy, underscoring urgent need for alternative approaches. Drug repurposing, characterized by utilization existing drugs novel clinical...
School health education issupposed to be one of the most efficient strategies for providing instruction and experiences that prepare young people their roles as healthy, productive adolescentsandalso prevent major social troubles.As per WHO data status school students is much compromised a good way address this problem (SHS guidelines 2021). Lifestyle disorder totally depends on social, mental, physical behavioral practices. So, inculcation healthy practices among through Health Education...
Abstract Triple negative breast cancer, an inherently aggressive disease, is further impaired by the limited therapeutic options and chemotherapy-resistance; hence, elucidating signaling nodes underlying chemotherapy resistance of major interest. Focusing on differentially expressed genes in recurrent TNBC, we identified TRIM29, a ubiquitin ligase belonging to TRIM family, as uniquely enriched protein chemoresistant TNBC. Here, demonstrate that TNBC cells are aggressive, exhibiting elevated...
Information about fusion transcripts in acute lymphoblastic leukemia (ALL) is used to risk-stratify patients, decide on the treatment and detect minimal residual disease. This study was conducted determine frequency of common BCR-ABL, TEL-AML1, MLL-AF4 E2A-PBX1 for B-ALL SIL-TAL1 T-ALL as seen at a tertiary care center India.Up 304 new cases ALL (271 33 T-ALL) diagnosed morphology, cytochemistry immunophenotyping were studied. All screened by RT-PCR.Both our B- (218/271; 80.4%) (26/33;...
Platelet hyperserotonemia in a subset of Autism Spectrum Disorder (ASD) probands, efficacy selective serotonin reuptake inhibitors (SSRIs) reducing behavioral deficits and gender-bias normal (5-hydroxy tryptamine or 5-HT) synthesis suggest disruption stringent regulation metabolism ASD. Therefore, we investigated the changes 5-HT 5-hydroxy indole acetic acid (5-HIAA) ASD probands to assess its effect on behavior male female probands. cases (n = 215) were examined using childhood autism...
Mutation of nucleophosmin (NPM1) gene in the absence FLT3-ITD (FMS related tyrosine kinase 3 - internal tandem duplications) mutation carries a good prognosis cytogenetically normal acute myeloid leukaemia (AML). NPM1, multifunctional nucleolar phosphoprotein that shuttles between nucleus and cytoplasm, gets trapped cytoplasm when mutated. Immunohistochemical (IHC) demonstration its aberrant cytoplasmic location (NPMc+) has been suggested as simple substitute for standard screening molecular...
Glucocorticoid (GC), such as prednisolone, is an essential component of multidrug chemotherapy regimen for pediatric acute lymphoblastic leukemia (ALL). Resistance to GC in cells associated with disease progression and poor prognosis. Despite the extensive use many years, molecular mechanisms underlying its resistance ALL have not been fully uncovered. Recent studies shown a potential role EMP1, CASP1, NLRP3 genes prednisolone response. In this study on 148 B-ALL patients, we studied these...
Attention deficit hyperactivity disorder (ADHD) is characterized by symptoms of inattention, excessive motor activity and impulsivity detected mostly during childhood. These traits are known to be controlled monoamine neurotransmitters, chiefly dopamine, serotonin norepinephrine. Monoamine oxidase A (MAOA) B (MAOB), two isoenzymes bound the outer membrane mitochondria, involved in degradation monoamines were explored for association with ADHD different ethnic groups. In present study, few...
Abstract T-acute lymphoblastic leukemia (T-ALL) is a heterogeneous malignancy characterized by the abnormal proliferation of immature T-cell precursors. Despite advances in immunophenotypic classification, understanding molecular landscape and its impact on patient prognosis remains challenging. In this study, we conducted comprehensive RNA sequencing cohort 35 patients with T-ALL to unravel intricate transcriptomic profile. Subsequently, validated prognostic relevance 23 targets,...
Breast cancer is a heterogeneous disease comprising multiple molecularly distinct subtypes with varied prevalence, prognostics, and treatment strategies. Among them, triple-negative breast cancer, though the least prevalent, most aggressive subtype, limited therapeutic options. Recent emergence of competing endogenous RNA (ceRNA) networks has highlighted how long noncoding RNAs (lncRNAs), microRNAs (miRs), mRNA orchestrate complex interplay meticulously modulating functionality. Focusing on...
T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease, characterized by an abnormal transformation of T cells into highly proliferative leukemic lymphoblasts. Identification common genetic alterations has provided promising opportunities for better risk stratification in T-ALL. Current treatment T-ALL still poses the major challenge integrating knowledge molecular clinical setting. We utilized Multiplex Ligation Dependent Probe Amplification (MLPA) method to...
Introduction: Alloimmunisation to red blood cell antigens, resulting from genetic disparities between donors and recipients, is one of the risks associated with transfusions. Antibody screening cells are used detect unexpected antibodies. The risk alloimmunisation higher in patients who have undergone multiple Aim: To estimate frequency various Red Blood Cell (RBC) alloantibodies determine types antibodies present repeatedly transfused patients. Materials Methods: This cross-sectional study...
Acute myeloid leukemia with normal cytogenetics (CN-AML) represents a heterogeneous group having diverse genetic mutations. Understanding the significance of each these mutations is necessary. In this study, we evaluated prognostic role MN1 expression in adult CN-AML patients.