A5024739498- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Hepatitis Viruses Studies and Epidemiology
- Pancreatitis Pathology and Treatment
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Liver Diseases and Immunity
- Extracellular vesicles in disease
- Organ Transplantation Techniques and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Viral Infections and Immunology Research
- Alcohol Consumption and Health Effects
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- CRISPR and Genetic Engineering
- Autophagy in Disease and Therapy
- Bacteriophages and microbial interactions
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- COVID-19 Clinical Research Studies
- Animal Disease Management and Epidemiology
All India Institute of Medical Sciences
2016-2025
All India Institute of Medical Sciences Bhopal
2023
All India Institute of Medical Sciences Raipur
2023
ICMR-National Institute of Virology
2019
Government of India
2019
Institute of Life Sciences
2019
Post Graduate Institute of Medical Education and Research
2019
University of Michigan
2017
University Gastroenterology
2017
Northwestern University
2005-2011
Hepatitis E virus (HEV) causes acute hepatitis in many parts of the world including Asia, Africa and Latin America. Though self-limiting normal individuals, it results ~30% mortality infected pregnant women. It has also been reported to cause chronic organ transplant patients. Of seven viral genotypes, genotype-1 infects humans is a major public health concern South Asian countries. Sporadic cases genotype-3 4 infection human animals such as pigs, deer, mongeese have primarily from...
Exosomes are nanovesicles (30–120 nm) of endosomal origin. These exosomes contain various functional proteins and RNAs that could be used for therapeutic purposes. Currently, having a standard method exosome isolation retaining its biological properties with increased yield purity is major challenge. The most commonly differential ultracentrifugation but it has own disadvantages, which include high time consumption, low due to disruption integrity, protein contaminants. In this study, we...
Hepatitis E virus (HEV) causes an acute, self-limiting hepatitis in healthy individuals and leads to chronic disease immunocompromised individuals. HEV infection pregnant women results a more severe outcome, with the mortality rate going up 30%. Though usually sporadic infection, epidemics have been reported developing resource-starved countries. No specific antiviral exists against HEV. A combination of interferon ribavirin therapy has used control some success. Zinc is essential...
The aim of this study was to assess the use thromboelastography (TEG)-directed blood product transfusion in cirrhotic patients with acute variceal bleeding compared conventional for correction coagulopathy.Coagulopathy is common cirrhosis. Recommendations parameters coagulation-platelets and international normalized ratio before endoscopy bleeding-need more validation.In randomized controlled trial, severe coagulopathy were either TEG-guided or from March 2017 December 2017. primary outcome...
Summary Novel direct‐acting antivirals ( DAA s) are now the standard of care for management hepatitis C virus HCV ) infection. Branded s associated with high sustained virological response at 12 weeks post‐completion therapy SVR 12), but costly. We aimed to assess efficacy generic oral in a real‐life clinical scenario. Consecutive patients known infection who were treated generic‐oral regimens (May 2015 January 2017) included. Demographic details, prior and documented. Four hundred ninety...
Summary Background In cirrhosis patients with acute variceal bleeding (AVB), the optimal duration of vasoconstrictor therapy after endoscopic haemostasis is unclear. Aims We aimed to compare efficacy 1‐day versus 3‐day terlipressin in AVB post‐endoscopic intervention. The primary objective was rebleeding at 5 days between two arms. Secondary objectives included and mortality rates 6 weeks. Methods this open‐label, randomised controlled trial, were either or therapy. Results A total 150...
Background Mesenchymal stem cells (MSCs) mediate immunomodulation through various mechanisms, including apoptosis, efferocytosis, and mitochondrial transfer. Our study investigates the impact of hypoxia preconditioning on immune metabolic reprogramming immunomodulatory potential MSCs in acute graft-versus-host disease (aGVHD). Additionally, we explored differential effects tissue-specific MSCs, specifically bone marrow (BM) Wharton Jelly (WJ), elucidated mechanisms underlying variability...
Background/Objectives: Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy. Barcelona Clinic Liver Cancer (BCLC) guidelines recommend antiangiogenic agents with immune checkpoint inhibitors as first-line therapy for advanced HCC. We present our experience of treating HCC patients Atezolizumab-Bevacizumab, their response rates, adverse events, survival, and survival predictors. Methods: This retrospective analysis included diagnosed at All India Institute Medical...
There is a paucity of data on the clinical presentations and outcomes Corona Virus Disease-19 (COVID-19) in patients with underlying liver disease. We aimed to summarize COVID-19-positive compare historical controls.Patients known chronic disease who presented superimposed COVID-19 (n = 28) between 22 April 2020 June were studied. Seventy-eight cirrhotic without included as controls for comparison.A total 28 (two cirrhosis, one compensated sixteen acute decompensation [AD], nine...
Highly-pathogenic avian influenza virus (HPAIV) and Newcastle disease (NDV) are the two most important poultry viruses in world. Natural low-virulence NDV strains have been used as vaccines over past 70 years with proven track records. We previously developed a reverse genetics system to produce low-virulent vaccine strain LaSota from cloned cDNA. This allows us use vector for other pathogens.Here, we constructed recombinant NDVs (rNDVs) each of which expresses hemagglutinin (HA) gene HPAIV...
Highly pathogenic avian influenza virus (HPAIV) subtype H5N1 causes severe disease and mortality in poultry. Increased transmission of HPAIV from birds to humans is a serious threat public health. We evaluated the individual contributions each three surface proteins, namely, hemagglutinin (HA), neuraminidase (NA), M2 induction HPAIV-neutralizing serum antibodies protective immunity chickens. Using reverse genetics, recombinant Newcastle viruses (rNDVs) were engineered, expressing HA, NA, or...
Abstract Background and Aim: Acute on chronic liver failure (ACLF) because of precipitating factors (variceal bleed/infections) identifies cirrhotics at risk for high short‐term mortality. Information ACLF acute hepatic insults is lacking. The aim the study was to evaluate in their effect course outcome. Methods: In a prospective study, 213 consecutive patients were included. Etiology insult, frequency silent, overt disease (CLD), organ (OF), outcomes assessed. Prognostic models such as...
Comprehensive knowledge of host-pathogen interactions is central to understand the life cycle a pathogen and devise specific therapeutic strategies. Protein-protein (PPIs) are key mediators interactions. Hepatitis E virus (HEV) major cause viral hepatitis in humans. Recent reports also demonstrate its extrahepatic manifestations brain. Toward understanding molecular details HEV cycle, we screened human liver fetal brain cDNA libraries identify host interaction partners proteins encoded by...
Results of endovascular interventions in hepatic venous outflow tract obstruction (HVOTO) have been reported from limited studies. Treatment outcomes and prognostic scores need further validation.To evaluate treatment for an Indian population.Consecutive patients with diagnosed at a tertiary centre were included. Technical success clinical response after interventional therapy documented. Predictors survival assessed Cox-proportional model. A new score was derived the factors significant on...
Acute-on-chronic liver failure (ACLF) may be precipitated by various hepatic insults. The present study evaluated the outcomes of ACLF with different acute insults.A total 368 patients were included. Data collected included etiologies insult and underlying chronic disease, organ failure. Model for end-stage disease (MELD), consortium (CLIF)-C ACLF, physiology health evaluation (APACHE) II scores calculated. Predictors survival assessed Cox proportional hazard model.The most frequent was...
Butyrate, a histone deacetylase inhibitor, has several therapeutic applications, including cancer. However, the effect of butyrate in HBV replication is not known so far. It was hypothesized that might inhibit and host cell proliferation via SIRT‐1. found increased expression SIRT‐1 Hep G2.2.15 cells (HBV expressing cells) than G2 cells. Next Acetylated p53 (Ac‐p53) were measured liver biopsy samples chronic hepatitis B (CHB) patients with high viral load compared to CHB low there Ac‐p53...