A5005042373- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Neutropenia and Cancer Infections
- Lymphoma Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Hematopoietic Stem Cell Transplantation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- COVID-19 Clinical Research Studies
- Cancer Cells and Metastasis
- Hematological disorders and diagnostics
- Mycobacterium research and diagnosis
- Neurological Complications and Syndromes
- Acute Lymphoblastic Leukemia research
- COVID-19 and healthcare impacts
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- Erythrocyte Function and Pathophysiology
- Viral-associated cancers and disorders
- Cancer Treatment and Pharmacology
- RNA modifications and cancer
All India Institute of Medical Sciences
2015-2025
All India Institute of Medical Sciences Raipur
2019-2024
All India Institute of Medical Sciences Bhopal
2019-2024
Rajiv Gandhi Cancer Institute and Research Centre
2016-2023
Creative Commons
2023
National Institute of Medical Statistics
2023
Safdarjang Hospital
2010-2021
Vardhman Mahavir Medical College & Safdarjung Hospital
2015-2021
Lok Nayak Jai Prakash Narayan Hospital
2017
BLK Super Speciality Hospital
2016-2017
Background Mesenchymal stem cells (MSCs) mediate immunomodulation through various mechanisms, including apoptosis, efferocytosis, and mitochondrial transfer. Our study investigates the impact of hypoxia preconditioning on immune metabolic reprogramming immunomodulatory potential MSCs in acute graft-versus-host disease (aGVHD). Additionally, we explored differential effects tissue-specific MSCs, specifically bone marrow (BM) Wharton Jelly (WJ), elucidated mechanisms underlying variability...
Background: Mesenchymal stem cell-based therapy faces challenges that have driven interest in MSCs-derived culture-conditioned media (CCM) as a cell-free alternative. Our study aims to optimize the dose, and collection timing of CCM enhance its therapeutic efficacy aGVHD, while also standardizing co-culture conditions for CD3+ T-cell interaction with CCM. Material Methods: Human MSCs were isolated from BM WJ subsequently preconditioned under hypoxic (1% O₂) 24 hours tri-gas incubator....
ABSTRACT Deficiency of adenosine deaminase 2 (DADA2) is a rare autosomal recessive disorder characterized by vasculopathy, immunodeficiency, and hematological abnormalities. Its presentation as infantile pure red cell aplasia (PRCA) often mimics Diamond Blackfan anemia (DBA), leading to diagnostic delays suboptimal management. This study retrospectively analyzed nine cases DADA2‐related PRCA diagnosed over 5 years at tertiary care hospital. All patients harbored homozygous ADA2 mutations,...
Abstract Background Acute Graft-versus-Host-Disease (aGvHD) is a major immune complication following allogenic hematopoietic stem cell transplantation (Allo-HSCT), initiated by conditioning regimen-associated tissue damage. It involves the complex interplay of cells and cytokines. Our study aims to leverage machine learning (ML) algorithms on cytokine profile Allo-HSCT recipients develop biomarker-based classification models predict onset aGvHD at time engraftment. Materials Methods Seventy...
Introduction: Iron-Deficiency Anemia (IDA) is a global burden affecting more than billion individuals. It most prevalent due to nutritional deficiencies. Researchers have linked Selenium (Se) anemia and erythropoiesis. Aim: This interventional-study was designed investigate the plasma Se concentration its supplementation impact in IDA patients receiving standard treatment. Methodology: In present study, total of 215 were enrolled from different departments AIIMS, New Delhi, after getting...
Abstract Background Patients post allogeneic stem cell transplantation (allo SCT ) are expected to be at high risk of tuberculosis ( TB owing underlying immunosuppression. We conducted a retrospective study in patients allo for clinical features and factors associated with . Methods Records all transplanted from January 1, 2012 until December 31, 2015 were reviewed. Diagnosis was considered if Mycobacterium cultured samples or acid‐fast bacilli AFB demonstrated on histopathology/smears. A...
Congenital dyserythropoietic anemia (CDA) are a diverse category of heritable anemia. The causative genetic abnormalities interfere with the normal developmental process erythrocyte maturation inside bone marrow. As consequence, red blood cell precursors die prematurely in marrow (ineffective erythropoiesis) and altered mature RBCs that come to peripheral have reduced survival. Due relative rarity resemblance other common disorders, diagnosis is often delayed. Apart from having symptoms...
Abstract Objectives Pediatric myelofibrosis is a rare entity with the largest reported series of 19 cases. We describe here clinicopathological spectrum and outcomes 15 cases pediatric myelofibrosis. Methods Case files patients less than 18 years were retrieved from January 2016 to 2019, idiopathic after exhaustive work‐up studied. Their profiles studied then followed up for resolution malignant transformation. Results Of myelofibrosis, transfusion‐dependent anemia (14/15) was most common...
Background Acute respiratory distress syndrome (ARDS) is a frequent complication of COVID-19 and associated with component thrombo-inflammation cytokine storm. also affects the hemostatic system causing multiple coagulation abnormalities that cause concern needs to be addressed. Objective We aimed assess parameters patients identify whether they could used as potential prognostic biomarkers predict ARDS immediate outcomes. Methods This was prospective study done on 68 at four serial time...