A5020686510- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Multiple Myeloma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Neuroendocrine Tumor Research Advances
- Ovarian cancer diagnosis and treatment
- Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Treatments and Studies
- Hematopoietic Stem Cell Transplantation
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Chronic Myeloid Leukemia Treatments
- Pleural and Pulmonary Diseases
- PI3K/AKT/mTOR signaling in cancer
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Gastric Cancer Management and Outcomes
All India Institute of Medical Sciences
2016-2025
DR. B.R.A. Institute Rotary Cancer Hospital
2016-2025
All India Institute of Medical Sciences Raipur
2018-2025
All India Institute of Medical Sciences Bhopal
2018-2025
University of Arkansas for Medical Sciences
2025
Lung cancer is one of the commonest and most lethal cancers throughout world. The epidemiological pathological profile varies among different ethnicities geographical regions. At present adenocarcinoma histological subtype non-small cell lung (NSCLC) in Western Asian countries. However, India squamous carcinoma has been reported as type series. aim study was to analyze current clinico-pathological survival at our centre.We analyzed 434 pathologically confirmed cases registered centre over a...
Hand-foot syndrome (HFS) is a dose-limiting side effect of capecitabine. Celecoxib prevents HFS by inhibiting cyclooxygenase-2 (COX-2) that upregulated because the underlying associated inflammation. However, systemic effects celecoxib have limited routine prescription. Topical diclofenac inhibits COX-2 locally with minimal risk adverse events. Therefore, we conducted this study to assess efficacy topical in prevention capecitabine-induced HFS.
ABSTRACT Background: Nivolumab has shown significant therapeutic benefits in treating non-small-cell lung carcinoma (NSCLC) and renal cell (RCC). Objectives: The primary objective of the study was to assess safety tolerability nivolumab Indian patients with advanced NSCLC or RCC. secondary evaluate frequency severity TRAEs. Materials Methods: In this single-arm, open-label, multicenter, prospective Phase IV study, we enrolled 100 (70 locally advanced/metastatic 30 RCC) from seven sites India...
<b><i>Introduction:</i></b> Inactivating mutations of the <i>SMARCA4</i> (SWI/SNF-related, matrix-associated, actin-dependent regulator chromatin, subfamily A, member 4) gene and/or loss BRG1 (brahma-related 1) protein defines SMARCA4-deficient thoracic sarcoma (SMARCA4-dTS), an aggressive neoplasm with a usually fatal outcome. Similar mutations/BRG1 is also seen in subset non-small cell lung carcinomas (NSCLCs; SMARCA4-dNSCLCs) that lack alterations...
Background & objectives: Survival of patients with multiple myeloma (MM) has improved in the past two decades following use novel agents and autologous stem cell transplantation. To determine predictors long-term outcome, data MM who underwent transplantation (ASCT) at a tertiary care centre north India were retrospectively analyzed. Methods: Between 1995 2016, 349 ASCT. Patients' median age was 52 yr, ranging from 29 to 68 68.2 per cent males. Thirty three had international staging system...
The incidence of symptomatic brain metastasis at diagnosis in non-small-cell lung cancer (NSCLC) is 5%-10%, and up to 40% develop during the disease course. There a paucity data supporting role imaging asymptomatic cases particularly from resource-constraint settings. Here, we present our experience mandatory baseline with contrast-enhanced computed tomography (CECT) scans all patients NSCLC.This was prospective observation study NSCLC CECT CNS examination. All histology proven diagnosed...
Background: MicroRNAs (miRNAs) play an important regulatory role and serve as biomarkers in various human cancers. However, their the prognosis predicting response to therapy Indian lung cancer patients is not fully explored. Methods: We collected surgically resected tumors paired adjacent normal tissues from 29 early-stage tissue biopsies 103 locally advanced metastatic this prospective study. quantified expression levels of miR-375-3p, miR-197-3p, miR-15a-5p using TaqMan Advanced miRNA...
PURPOSE Prevention of chemotherapy-induced nausea and vomiting with currently recommended NK1 receptor antagonist–based triplet during carboplatin (AUC ≥4) chemotherapy appears inadequate. A comparative study between olanzapine combination is lacking. METHODS This was a single-center, phase III, prospective randomized, double-blind, placebo-controlled superiority comparing (olanzapine, ondansetron, dexamethasone [OOD]-experimental arm) fosaprepitant (fosaprepitant, [FOD]-standard in...
Introduction: Small cell lung carcinomas (SCLC) are characterized by loss of function mutations in genes encoding for p53 (tumor protein p53— TP53 ) and retinoblastoma transcriptional corepressor 1 ( RB1 proteins the majority tumors. They aggressive, usually present with metastatic disease, treated platinum-based chemotherapy overall poor outcomes. Epidermal growth factor receptor EGFR) mutations, classically associated primary adenocarcinomas, have been reported rare de novo SCLC outside...
BEAM (BCNU, etoposide, cytrabine, melphalan) is the most widely used high dose chemotherapy regimen for autologous transplant in lymphoid malignancies. We report our early experience with an alternative LEAM where BCNU was replaced oral analogue CCNU (lomustine) to tide over non-availability of BCNU. Fifty one patients relapsed or refractory lymphoma who received (n= 34) and 17) from September 2001 February 2012 were analyzed. From October 2009 onwards as conditioning instead conventional...