A5064634732- Synthesis and biological activity
- Computational Drug Discovery Methods
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Lung Cancer Treatments and Mutations
- Quinazolinone synthesis and applications
- HER2/EGFR in Cancer Research
- Tuberculosis Research and Epidemiology
- Click Chemistry and Applications
- Bioactive Compounds and Antitumor Agents
- Multicomponent Synthesis of Heterocycles
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cholinesterase and Neurodegenerative Diseases
- Electrochemical sensors and biosensors
- Natural Antidiabetic Agents Studies
- Biochemical and Molecular Research
- Essential Oils and Antimicrobial Activity
- Synthesis of β-Lactam Compounds
- Parkinson's Disease Mechanisms and Treatments
- Phytochemistry and Biological Activities
- Chemical Synthesis and Analysis
- Antimicrobial Peptides and Activities
- Pneumocystis jirovecii pneumonia detection and treatment
- Genomics, phytochemicals, and oxidative stress
Shri Vile Parle Kelavani Mandal
2016-2025
ACPM Dental College and Hospital
2023
University of Anbar
2023
Covenant University
2022
North Maharashtra University
2022
University of KwaZulu-Natal
2014-2021
Durban University of Technology
2015
University of Mississippi Medical Center
2001-2004
Jackson Memorial Hospital
2001
The polyelectrolyte complexes (PECs) are versatile formulations formed by electrostatic interactions between oppositely charged biopolymers. PECs have been investigated widely the researchers to explore virtues of this formulation viz. high biocompatibility, excellent biodegradability, low toxicity, cost-effective, environment-friendly, and energy-efficient production. prime object present review is prominent features including mechanism PEC formation, structural models PECs, involved in...
Considering the current dramatic and fatal situation due to high spreading of SARS-CoV-2 infection, there is an urgent unmet medical need identify novel effective approaches for prevention treatment Coronavirus disease (COVID 19) by re-evaluating repurposing known drugs. For this, tomatidine patchouli alcohol have been selected as potential drugs combating virus. The hit compounds were subsequently docked into active site molecular docking analyses revealed that both can bind 3CLpro, PLpro,...
Breast cancer is the most frequent female and second cause of cancer-related deaths among women around world. Two thirds breast patients have hormone-dependent tumors, which very likely be treated with hormonal therapy. Aromatase involved in biosynthesis estrogen thus a critical target for cancer. In this study, order to identify new aromatase enzyme inhibitors, series benzimidazole-1,3,4-oxadiazole derivatives were synthesized characterized by 1H NMR, 13C MS spectra analyses. vitro...
The seaweed industries generate considerable amounts of waste that must be appropriately managed. This biomass from marine is a rich source high-value bioactive compounds. Thus, this can adequately utilized by recovering the compounds for therapeutic purposes. Histone deacetylases (HDACs) are key epigenetic regulators established as one most promising targets cancer chemotherapy. In present study, our objective to find HDAC 2 inhibitor. We performed top-down in silico methodologies identify...
An essential target for COVID-19 is the main protease of SARS-CoV-2 (Mpro). With objective targeting this receptor, a novel set pyrido[1,2-a]pyrrolo[2,3-d]pyrimidines with terminal carboxamide fragments was designed, synthesized, and considered as an initial motif creation effective pan-coronavirus inhibitors. Accordingly, nine derivatives (21-29) have been introduced in vitro assay to evaluate their antiviral activity cytotoxicity effect against virus using Vero cells. The obtained data...
The condensation of phthalic anhydride afforded structurally modified isoindoline-1,3-dione derivatives with selected amino-containing compounds. title compounds (2-30) have been characterized by thin-layer chromatography (TLC), infrared spectroscopy, 1H and 13C NMR mass spectroscopy. All the were assessed for their antimycobacterial activity toward H37Rv strain a dual read-out assay method. Among synthesized compounds, compound 27 possessed significant IC50 18 μM, making it most potent...
Thirteen isopropyl chalcones (CA1-CA13) were synthesized and evaluated for their inhibitory activity against monoamine oxidase (MAO). All compounds inhibited MAO-B more effectively than MAO-A. Compound CA4 most potently with an IC50 value of 0.032 μM, similar to that CA3 (IC50 = 0.035 μM) high selectivity index (SI) values over MAO-A (SI 49.75 353.23, respectively). The -OH (CA4) or -F (CA3) group at the para position on A ring provided higher inhibition other substituents (-OH ≥ > -Cl -Br...
Anethum graveolens L. has been known as an aromatic, medicinal, and culinary herb since ancient times. The main purpose of this study was to determine the chemical composition, antibacterial, antibiofilm, anti-quorum sensing activities essential oil (EO) obtained by hydro-distillation aerial parts. Twelve components were identified, representing 92.55% analyzed oil. Limonene (48.05%), carvone (37.94%), cis-dihydrocarvone (3.5%), trans-carvone (1.07%) identified constituents. Results showed...
A class of 2-(1H-imidazol-1-yl)-1-phenylethyl cinnamates 6a-6j and 2-(1H-benzo[d]imidazol-1-yl)-1-phenylethyl 7a-7j were synthesized, their synthesis was validated using various spectroscopic techniques like IR, NMR, Mass spectrometry. In addition, the compounds assessed for in-vitro antibacterial against gram-positive gram-negative strains antifungal six different fungal strains. Compounds 6 g, 7 b, 7f, g exhibited significant activity all bacterial ranging from MIC = 12.5-50 µg/mL,...
Abstract Belonging to the Fabaceae family, Dalbergia sissoo , a versatile plant, has gained prominence for its potent medicinal attributes, especially antipyretic, anti-inflammatory, and cardioprotective properties, as well use of leaf juice in cancer treatment. Despite these recognized applications by natives tribals, comprehensive insight into biological activities chemical composition remains limited. This study aimed explore cytotoxic potential sequentially extracted extracts from using...