A5055068430- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Circular RNAs in diseases
- RNA Research and Splicing
- Mycobacterium research and diagnosis
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Acute Lymphoblastic Leukemia research
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- Lymphoma Diagnosis and Treatment
- Extracellular vesicles in disease
- Chronic Lymphocytic Leukemia Research
- NF-κB Signaling Pathways
- Hematopoietic Stem Cell Transplantation
- Ubiquitin and proteasome pathways
- T-cell and B-cell Immunology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- CAR-T cell therapy research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Virus-based gene therapy research
- Immune Response and Inflammation
- interferon and immune responses
University of California, Los Angeles
2015-2025
UCLA Jonsson Comprehensive Cancer Center
2011-2024
Broad Center
2014-2024
University of Colorado Cancer Center
2011-2023
University of Colorado Denver
2011-2023
Ronald Reagan UCLA Medical Center
2022
APLA Health
2022
Comprehensive Blood & Cancer Center
2016-2021
UCLA Health
2014-2019
Olive View-UCLA Medical Center
2016
Excessive or inappropriate activation of the immune system can be deleterious to organism, warranting multiple molecular mechanisms control and properly terminate responses. MicroRNAs (miRNAs), ∼22-nt-long noncoding RNAs, have recently emerged as key posttranscriptional regulators, controlling diverse biological processes, including responses non-self. In this study, we examine role miR-146a using genetically engineered mice show that targeted deletion gene, whose expression is strongly...
MicroRNA-155 (miR-155) has emerged as a critical regulator of immune cell development, function, and disease. However, the mechanistic basis for its impact on hematopoietic system remains largely unresolved. Because miRNAs function by repressing specific mRNAs through direct 3'UTR interactions, we have searched targets miR-155 implicated in regulation hematopoiesis. In present study, identify Src homology-2 domain-containing inositol 5-phosphatase 1 (SHIP1) target miR-155, and, using gain...
Mammalian microRNAs are emerging as key regulators of the development and function immune system. Here, we report a strong but transient induction miR-155 in mouse bone marrow after injection bacterial lipopolysaccharide (LPS) correlated with granulocyte/monocyte (GM) expansion. Demonstrating sufficiency to drive GM expansion, enforced expression cells caused proliferation manner reminiscent LPS treatment. However, miR-155-induced populations displayed pathological features characteristic...
MicroRNA miR-146a has been implicated as a negative feedback regulator of NF-κB activation. Knockout the gene in C57BL/6 mice leads to histologically and immunophenotypically defined myeloid sarcomas some lymphomas. The are transplantable immunologically compromised hosts, showing that they true malignancies. animals also exhibit chronic myeloproliferation their bone marrow. Spleen marrow cells show increased transcription NF-κB–regulated genes tumors have higher nuclear p65. Genetic...
The production of blood cells depends on a rare hematopoietic stem-cell (HSC) population, but the molecular mechanisms underlying HSC biology remain incompletely understood. Here, we identify subset microRNAs (miRNAs) that is enriched in HSCs compared with other bone-marrow cells. An vivo gain-of-function screen found three these miRNAs conferred competitive advantage to engrafting cells, whereas attenuated Overexpression most advantageous miRNA, miR-125b, caused dose-dependent...
The NCCN Guidelines for Acute Myeloid Leukemia (AML) provide recommendations the diagnosis and treatment of adults with AML based on clinical trials that have led to significant improvements in treatment, or yielded new information regarding factors prognostic importance, are intended aid physicians decision-making. These Insights focus recent select updates Guidelines, including familial genetic alterations AML, postinduction postremission strategies low-risk acute promyelocytic leukemia...
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by the clonal expansion of blasts in peripheral blood, bone marrow, and/or other tissues. It most common form acute among adults and accounts for largest number annual deaths from leukemias United States. Like AML, blastic plasmacytoid dendritic cell neoplasm (BPDCN) malignancy. rare aggressive proliferation precursors cells that frequently involves skin, central nervous system, organs This discussion...
Posttranscriptional control of gene expression is important for defining both normal and pathological cellular phenotypes. In vitro, RNA-binding proteins (RBPs) have recently been shown to play roles in posttranscriptional regulation; however, the contribution RBPs cell specification not well understood. Here, we determined that RBP insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) specifically overexpressed mixed lineage leukemia-rearranged (MLL-rearranged) B-acute lymphoblastic...
MicroRNA-125b (miR-125b) is up-regulated in patients with leukemia. Overexpression of miR-125b alone mice causes a very aggressive, transplantable myeloid Before leukemia, these do not display elevation white blood cells the spleen or bone marrow; rather, hematopoietic compartment shows lineage-skewing, cell numbers dramatically increased and B-cell severely diminished. exerts this effect by up-regulating number common progenitors while inhibiting development pre-B cells. We applied sponge...
During inflammation and infection, hematopoietic stem progenitor cells are stimulated to proliferate differentiate into mature immune cells, especially of the myeloid lineage. MicroRNA-146a (miR-146a) is a critical negative regulator inflammation. Deletion miR-146a produces effects that appear as dysregulated inflammatory hematopoiesis, leading decline in number quality (HSCs), excessive myeloproliferation, and, ultimately, HSC exhaustion neoplasms. At cellular level, defects attributable...
Long non-coding RNAs (lncRNAs) play a variety of cellular roles, including regulation transcription and translation, leading to alterations in gene expression. Some lncRNAs modulate the expression chromosomally adjacent genes. Here, we assess roles lncRNA CASC15 nearby gene, SOX4, its function RUNX1/AML translocated leukemia. is conserved that was upregulated pediatric B-acute lymphoblastic leukemia (B-ALL) with t (12; 21) as well acute myeloid (AML) (8; 21), both which are associated...
Autoreactive CD4 T cells that differentiate into pathogenic Th17 can trigger autoimmune diseases. Therefore, investigating the regulatory network modulates differentiation may yield important therapeutic insights. miR-146a has emerged as a critical modulator of immune reactions, but its role in regulating autoreactive and organ-specific autoimmunity remains largely unknown. Here, we have reported miR-146a-deficient mice developed more severe experimental encephalomyelitis (EAE), an animal...
Abstract Long noncoding RNAs (lncRNA) have been found to play a role in gene regulation with dysregulated expression various cancers. The precise that lncRNA plays the pathogenesis of B-acute lymphoblastic leukemia (B-ALL) is unknown. Therefore, unbiased microarray profiling was performed on human B-ALL specimens, and it determined correlates cytogenetic abnormalities, which confirmed by qRT-PCR large set cases. Importantly, high BALR-2 correlated poor overall survival diminished response...