A5038546152- Prostate Cancer Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- Pancreatic function and diabetes
- Bladder and Urothelial Cancer Treatments
- Mycobacterium research and diagnosis
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Renal and related cancers
- Diabetes and associated disorders
- Xenotransplantation and immune response
- Antimicrobial Peptides and Activities
- Diagnosis and treatment of tuberculosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Genital Health and Disease
- Adrenal and Paraganglionic Tumors
- Immunotherapy and Immune Responses
- Urinary and Genital Oncology Studies
- Bariatric Surgery and Outcomes
All India Institute of Medical Sciences Bhopal
2007-2024
University of Minnesota
2015-2024
All India Institute of Medical Sciences
2011-2024
Erlanger Health System
2014-2024
All India Institute of Medical Sciences Raipur
2007-2024
University of Tennessee at Chattanooga
2014-2024
Cancer Research Center
2023
Mission Bio (United States)
2023
The Royal Wolverhampton NHS Trust
2021
DR. B.R.A. Institute Rotary Cancer Hospital
2021
Background. Overexpression of programmed death 1 (PD-1) receptor is thought to inhibit the effector T-cell response in human tuberculosis. However, precise mechanism such inhibition remains unclear. The present study addresses role PD-1 dampening host function among patients with pulmonary Methods. Expression and its ligands (PD-L1/L2) on T cells, B monocytes was evaluated by flow cytometry (FACS). In vitro stimulation peripheral blood mononuclear cells presence Mycobacterium tuberculosis...
The inadequacy of effector T-cell response in containment tubercle bacilli is believed to result the development disseminated forms tuberculosis (TB), such as miliary (MTB). Regulatory T cells (Treg) plausibly play a critical role immunopathogenesis TB by suppression immune against Mycobacterium at pathologic site(s). To understand Treg tuberculosis, we studied frequency and function derived from local disease site specimens (LDSS) patients with pleural effusion MTB clinical models contained...
CD4+CD25+Foxp3+ Regulatory T cells (Treg) and programmed death-1 (PD-1) molecules have emerged as pivotal players in immune suppression of chronic diseases. However, their impact on the disease severity, therapeutic response restoration human tuberculosis remains unclear. Here, we describe possible role Treg cells, M. driven expansion contribution PD-1 pathway to suppressive function among pulmonary (PTB) patients. Multicolor flow cytometry, cell culture, sorting ELISA were employed execute...
No AccessJournal of UrologyCLINICAL UROLOGY: Urologists at Work1 Feb 2004Use Gelatin Matrix Thrombin Tissue Sealant as an Effective Hemostatic Agent During Laparoscopic Partial Nephrectomy JOHN B. BAK, AMAR SINGH, and BIJAN SHEKARRIZ BAKJOHN BAK , SINGHAMAR SINGH SHEKARRIZBIJAN View All Author Informationhttps://doi.org/10.1097/01.ju.0000104800.97009.c6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract...
Suppression of T cell response is thought to be involved in the pathogenesis visceral leishmaniasis (VL). Regulatory (Treg) mediated immune-suppression reported animal models Leishmania infection. However, their precise role among human patients still requires pathologic validation. The present study aimed at understanding frequency dynamics and function Treg cells blood bone marrow (BM) VL patients. included 42 parasitologically confirmed patients, 17 healthy contact 9 normal specimens...
Previous work from our laboratory has demonstrated that during acute viral brain infection, glial cells modulate antiviral T cell effector responses through the PD-1: PD-L1 pathway, thereby limiting deleterious consequences of unrestrained neuroinflammation. Here, we evaluated pathway in development brain-resident memory (bTRM) following murine cytomegalovirus (MCMV) infection. Flow cytometric analysis immune was performed at 7, 14, and 30 days post-infection (dpi) to assess shift...
To evaluate the impact of a genomic classifier (GC) test for predicting metastasis risk after radical prostatectomy (RP) on urologists' decision-making about adjuvant treatment patients with high-risk prostate cancer.Patient case history was extracted from medical records each 145 pT3 disease or positive surgical margins (PSMs) RP treated by six high-volume urologists, five community practices. GC results were available 122 (84%) these patients. US board-certified urologists (n = 107)...
Abstract Immune tolerance to allografts has been pursued for decades as an important goal in transplantation. Administration of apoptotic donor splenocytes effectively induces antigen-specific murine studies. Here we show that two peritransplant infusions leukocytes under short-term immunotherapy with antagonistic anti-CD40 antibody 2C10R4, rapamycin, soluble tumor necrosis factor receptor and anti-interleukin 6 induce long-term (≥1 year) islet 5 nonsensitized, MHC class I-disparate, one II...
Though islet transplantation is now being considered as a gold standard to cure type 1 diabetes in patients without the threat of unaware hypoglycemia and severe episode, post-transplantation loss due intra-islet vasculature during isolation process compromises full functionality transplanted mass. Therefore, besides instant blood-mediated inflammatory reaction (IBMIR) induced within first 60 minutes intraportal vein, two weeks avascular window, prior adequate vascularization, responsible...
We prospectively evaluated the impact of body mass index (BMI) and prostate gland size on operative time, estimated blood loss (EBL) hospital stay (LOS) in patients undergoing laparoscopic radical prostatectomy at our institution.A total 70 consecutive prostatectomies were performed institution from May 2002 to April 2003. Patients who had pelvic lymphadenectomy excluded. A 62 cases available for analysis. Two converted open surgery. Perioperative data each group recorded, including patient...
No AccessJournal of UrologyAdult Urology: Oncology: Renal/Upper Tract/Bladder1 May 2005HIGHER THAN EXPECTED ASSOCIATION OF CLINICAL PROSTATE AND BLADDER CANCERSis companion ofHigher Than Expected Association Clinical Prostate and Bladder Cancers AMAR SINGH, YOSHIHISA KINOSHITA, PETER M. ROVITO, STEVE LANDAS, JON SILBERSTEIN, IMAD NSOULI, CHING Y. WANG, GABRIEL P. HAAS SINGHAMAR SINGH More articles by this author , KINOSHITAYOSHIHISA KINOSHITA ROVITOPETER ROVITO LANDASSTEVE LANDAS...
Peptidoglycan recognition proteins (PGRPs) are involved in the of pathogen-associated molecular patterns. The well known patterns include LPS from Gram-negative bacteria and lipoteichoic acid (LTA) Gram-positive bacteria. In this work, crystal structures two complexes short form camel PGRP (CPGRP-S) with LTA determined at 1.7- 2.1-Å resolutions, respectively, reported. Both compounds were held firmly inside complex formed four CPGRP-S molecules designated A, B, C, D. binding cleft is located...
Accumulation and retention of regulatory T-cells (Tregs) has been reported within post viral-encephalitic brains, however, the full extent to which these cells modulate neuroinflammation is yet be elucidated. Here, we used Foxp3-DTR (diphtheria toxin receptor) knock-in transgenic mice, upon administration low dose diphtheria (DTx) results in specific deletion Tregs. We investigated proliferation status various immune cell subtypes inflamed central nervous system (CNS) tissue. Depletion Tregs...
Objective:To assess the effect of an individualized genomic classifier (GC) test, for predicting metastasis following radical prostatectomy (RP), on urologists' adjuvant treatment decisions when caring high-risk patients.
Ureteral access sheaths were developed to facilitate difficult ureteroscopic in adults. We report our use of the ureteral sheath during standard procedures pediatric stone population.Eight patients underwent flexible ureteroscopy and holmium laser lithotripsy for symptomatic renal calculi between October 2003 2004. Average patient age was 9.3 years (range 4 13). There males females. Five 8 had bilateral stones endoscopic treatment at same operation. A 14Fr 20 cm Flexor used dilation ureter....
Epithelial–mesenchymal transition (EMT) is a highly dynamic process that occurs under normal circumstances; however, EMT also known to play central role in tumor progression and metastasis. Furthermore, of immune microenvironment (TIME) shaping anticancer immunity inducing the well recognized. Understanding key features critical for development effective therapeutic interventions. Given escape cancer treatment, we have carried out pan-cancer TIME analysis The Cancer Genome Atlas (TCGA)...