A5005234731- Fish Ecology and Management Studies
- Veterinary Oncology Research
- Pancreatitis Pathology and Treatment
- Inflammatory mediators and NSAID effects
- Cancer, Stress, Anesthesia, and Immune Response
- Water Quality and Resources Studies
- Pancreatic and Hepatic Oncology Research
- Ruminant Nutrition and Digestive Physiology
- Botanical Research and Chemistry
- Biological Control of Invasive Species
- Pancreatic function and diabetes
- Botany, Ecology, and Taxonomy Studies
- Estrogen and related hormone effects
- Hydrology and Sediment Transport Processes
- Phagocytosis and Immune Regulation
- Plant Ecology and Taxonomy Studies
- Plant and animal studies
- Veterinary Medicine and Surgery
- Fibroblast Growth Factor Research
- Weed Control and Herbicide Applications
- Microbial infections and disease research
- Click Chemistry and Applications
- Diabetes and associated disorders
- Reproductive System and Pregnancy
- Blood Coagulation and Thrombosis Mechanisms
University of Minnesota
2017-2023
University of Minnesota Medical Center
2021
California Animal Hospital
2007-2011
University of Illinois Urbana-Champaign
2004-2008
Hospital of the University of Pennsylvania
2005
Hebrew University of Jerusalem
1982-1997
Legacy Mount Hood Medical Center
1986-1988
Abstract Immune tolerance to allografts has been pursued for decades as an important goal in transplantation. Administration of apoptotic donor splenocytes effectively induces antigen-specific murine studies. Here we show that two peritransplant infusions leukocytes under short-term immunotherapy with antagonistic anti-CD40 antibody 2C10R4, rapamycin, soluble tumor necrosis factor receptor and anti-interleukin 6 induce long-term (≥1 year) islet 5 nonsensitized, MHC class I-disparate, one II...
Cyclooxygenase-2 (COX-2) is an inducible member of the family cyclooxygenase enzymes that has been implicated in genesis numerous cancers. The role COX-2 canine mammary neoplasia remains to be more clearly elucidated. goal study reported here was determine whether a direct association between levels expression and tumor histologic subtype exists carcinoma. Immunohistochemical analysis performed using polyclonal antiprostaglandin G/H synthase 2 IgG antibody. Sections from kidneys young dogs,...
Chronic pancreatitis (CP) is a potentially fatal disease of the exocrine pancreas, with no specific or effective approved therapies. Due to difficulty in accessing pancreas tissues, little known about local immune responses pathogenesis human CP. We sought characterise pancreatic using tissues derived from patients different aetiologies CP and non-CP organ donors order identify key signalling molecules associated CP.We performed single-cell level cellular indexing transcriptomes epitopes by...
Summary: Résumé: Zusammenfassung The alien weed flora of Israel comprises forty species out a total seventy‐seven adventive represented here. Twenty‐nine them occur in other countries the Middle East and they probably reached through these countries: rest me regarded as direct imports from their origin. About nine have already become major weeds, while twenty‐nine species, which are known noxious weeds parts world, active process spreading reaching this status. Details given ecology,...
In this retrospective study medical records of 11 cats with gastrointestinal lymphoma were evaluated to determine the efficacy radiation therapy when used in a rescue setting. All had relapsed or resistant lymphoma. Two fractions delivered over 2 days for total 800cGy. Acute effects not noted, except one cat that self-limiting loss appetite. Response was noted 10/11 cats. Median survival post-radiation 214 and overall median 355 days. This suggests abdominal irradiation feline well tolerated...
To determine whether cyclooxygenase-2 (COX-2) is expressed in canine hemangiosarcoma (HsA), histiocytic sarcoma (Hs), and grade-II mast cell tumor (MCT), we performed immunohistochemistry using COX-2 antibodies the aforementioned tumors. Twenty cases of each type were selected initially from Laboratory Pathology archives submitted through Matthew J. Ryan Veterinary Hospital University Pennsylvania. Immunohistochemistry was performed, a polyclonal antiprostaglandin endoperoxide synthase...
Background: Cyclooxygenase-2 (COX-2) and its principle enzymatic metabolite, prostaglandin E2 (PGE2), are implicated in cancer progression. Based upon immunohistochemical (IHC) evidence that several tumor types animals overexpress COX-2 protein, inhibitors used as anticancer agents dogs cats. Hypothesis: IHC is inaccurate for assessing tumor-associated protein activity. Methods: Five mammalian cell lines were assessed expression by Western blot analysis (WB), functional activity was based...
Background : Cyclooxygenase‐2 (COX‐2) and its principle enzymatic metabolite, prostaglandin E 2 (PGE ), are implicated in cancer progression. Based upon immunohistochemical (IHC) evidence that several tumor types animals overexpress COX‐2 protein, inhibitors used as anticancer agents dogs cats. Hypothesis IHC is inaccurate for assessing tumor‐associated protein activity. Methods Five mammalian cell lines were assessed expression by Western blot analysis (WB), functional activity was based...
Pancreatic fat may adversely affect β-cell mass and function, possibly via local release of non-esterified fatty acids, proinflammatory vasoactive factors released by adipose tissue. However, the effects intrapancreatic in patients with chronic pancreatitis undergoing total pancreatectomy islet autotransplantation (TPIAT) have not been studied. This study investigated whether pancreatic infiltration has a negative effect on metabolic outcomes following TPIAT.The association between diabetes...
This study sought to quantify in vitro antiproliferative effects of pamidronate feline cancer cells and assess feasibility use cats by assessing short-term toxicity dosing schedule with bone-invasive cancer. A retrospective pilot included eight bone invasive treated intravenous pamidronate. In vitro, reduced proliferation (P < 0.05). One cat combination chemotherapy two as a single agent after failing prior therapy had subjective clinically stable disease; median progression free interval...
Abstract Islet yield is an important predictor of acceptable glucose control after total pancreatectomy with islet autotransplantation (TP‐IAT). We assessed if pancreas volume calculated preoperative MRI could assess and postoperative outcomes. reviewed dynamic studies from 154 adult TP‐IAT patients (2009‐2016), associations between volumes digest equivalents (IEQs) were tested. In multivariate regression analysis, ( P < .001) HbA1c levels = .009) independently associated IEQs. The IEQ...
ABSTRACT Objective Chronic pancreatitis (CP) is a potentially fatal disease of the exocrine pancreas, with no specific or effective approved therapies. Due to difficulty in accessing pancreas tissues, little known about local immune responses pathogenesis human CP. We sought characterize using tissues derived from patients different etiologies CP and non-CP organ donors order identify key signaling molecules associated Design performed single-cell level cellular indexing transcriptomes...
Introduction: After pancreas digestion for TPIAT, we occasionally observe highly enriched, “naturally purified” (NP) islets, where exocrine tissue has been eliminated by chronic pancreatitis. These NP islets appear similar to COBE purified (CP) islets. We sought understand whether these maintain function, and the impact of transplanted on graft function. Methods: Patients, age ≥20 years, who received IAT products with volume ratio ≤ 2:1 were grouped as (n=21) or CP (n=9), their demographics,...
Background: In TPIAT, current final islet product (IP) sterility testing identifies microbial contamination for rapid antibiotic prophylaxis. We sought to (1) quantify “bioburden” (BB) during manufacturing, (2) understand which processes may reduce BB, and (3) develop patient-specific strategies lessen BB in IP. Methods: Pancreas preservation solution (PS) IP were assessed via BACTEC system, growth reported qualitatively (Y/N), species identified by clinical laboratory. Quantitative data...