A5038974374- Pancreatitis Pathology and Treatment
- Food Quality and Safety Studies
- Pancreatic and Hepatic Oncology Research
- Dermatology and Skin Diseases
- Herbal Medicine Research Studies
- Liver Disease Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Phagocytosis and Immune Regulation
- Reproductive System and Pregnancy
- Phytochemical Studies and Bioactivities
- Diabetes and associated disorders
- Immune cells in cancer
- Adipose Tissue and Metabolism
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Plant Virus Research Studies
- Cancer, Hypoxia, and Metabolism
- Gastrointestinal disorders and treatments
- Retinoids in leukemia and cellular processes
- Natural Products and Biological Research
- Agricultural Practices and Plant Genetics
- Phytochemistry and Bioactive Compounds
- Ginseng Biological Effects and Applications
Sejong University
2022-2025
Chungnam National University
2024
Stanford University
2020-2023
Yong In University
2023
Palo Alto University
2022
Seeders (South Korea)
2014-2020
University of Tennessee at Knoxville
2019
Soonchunhyang University Hospital
2018
University of Minnesota Medical Center
2014-2017
National Institute of Environmental Research
2017
The tomato (Solanum lycopersicum L.) is a model plant for genome research in Solanaceae, as well studying crop breeding.Genome-wide single nucleotide polymorphisms (SNPs) are valuable resource genetic and breeding.However, to do discovery of genome-wide SNPs, most methods require expensive high-depth sequencing.Here, we describe method SNP calling using modified version SAMtools that improved its sensitivity.We analyzed 90 Gb raw sequence data from nextgeneration sequencing two resequencing...
Licorice (Glycyrrhiza glabra L., Leguminosae) is frequently used in traditional medicine to treat inflammatory and allergic diseases. In this study, the main components (glycyrrhizin, 18β-glycyrrhetinic acid, isoliquiritin, liquiritigenin) were isolated from licorice, their anti-allergic effects, such as antiscratching behavior IgE production-inhibitory activity, evaluated both vitro vivo. Liquiritigenin acid most potently inhibited degranulation of RBL-2H3 cells induced by with antigen...
The aim of this study was to evaluate the effects Anemarrhena asphodeloides BUNGE (AA) on cholinergic memory deficits in mice. This agent has previously been used as an antipyretic, anti-inflammatory, anti-diabetic, and antidepressant traditional Chinese medicine. Mangiferin isolated from AA showed a dose-dependent inhibition acetylcholinesterase (AChE) activity (IC50 value, 62.8 μM). Cholinergic dysfunction induced mice by administering scopolamine, animals were then tested using passive...
Increasing evidence suggests that linker histone H1 can influence distinct cellular processes by acting as a gene-specific regulator. However, the mechanistic basis underlying such specificity and whether acts in concert with other chromatin-altering activities remain unclear. Here, we show one of subtypes, H1.2, stably interacts Cul4A E3 ubiquitin ligase PAF1 elongation complexes interaction potentiates target gene transcription via induction H4K31 ubiquitylation, H3K4me3, H3K79me2. Cul4A,...
Changes in intracellular Ca 2+ concentration ([Ca ] i ) play an important role the function and plasticity of synapses. We characterized changes [Ca produced by action potentials (APs) along two identified motor terminals found on separate muscle fibers Drosophila larvae examined factors that influence amplitude duration residual signal. were able to measure transients both single APs AP trains using Oregon Green 488 BAPTA-1 streaming images at 20–50 Hz. The decay after or was well fit a...
Adipose tissue macrophage (ATM) recruitment and activation play a critical role in obesity-induced inflammation insulin resistance (IR). The mechanism regulating ATM infiltration remains unclear. In this study, we found receptor interacting protein 140 (RIP140) can regulate the dynamics of that contribute to adipose remodeling. A high-fat diet (HFD) elevates RIP140 expression macrophages. We generated mice with knockdown macrophages using transgenic bone marrow transplantation procedures...
Macrophage classical (M1) versus alternative (M2) polarization is critical for the homeostatic control of innate immunity. Uncontrolled macrophage frequently implicated in diseases. This study reports a new functional role receptor-interacting protein 140 (RIP140) regulating this phenotypic switch. RIP140 required M1 activation, and its degradation to LPS-induced endotoxin tolerance (ET). Here, we found that failure establish degradation-mediated ET prevents M2 polarization, reducing level...
Chronic pancreatitis (CP) is a potentially fatal disease of the exocrine pancreas, with no specific or effective approved therapies. Due to difficulty in accessing pancreas tissues, little known about local immune responses pathogenesis human CP. We sought characterise pancreatic using tissues derived from patients different aetiologies CP and non-CP organ donors order identify key signalling molecules associated CP.We performed single-cell level cellular indexing transcriptomes epitopes by...
Abstract Background Conventional drug discovery has focused on developing synthetic chemicals. However, a number of chemical drugs have been withdrawn during preclinical stages or from the market due to toxicity concerns. Natural herbs receiving more attention lately because their relatively low levels and abundance historical medical documentation supporting use. Nevertheless, efforts find those that might help treat diseases frequently ad hoc need for knowledge regarding these compounds;...
<h3>Objectives</h3> To evaluate the effectiveness and cost-utility of addition different doses Pilates to an advice for non-specific chronic low back pain (NSCLBP) from a societal perspective. <h3>Design</h3> Randomised controlled trial with economic evaluation. <h3>Setting</h3> Physiotherapy clinic in São Paulo, Brazil. <h3>Participants</h3> 296 patients NSCLBP. <h3>Interventions</h3> All received were randomly allocated four groups (n=74 per group): booklet group (BG), once week (Pilates...
Chronic pancreatitis (CP) is considered an irreversible fibroinflammatory pancreatic disease. Despite numerous animal model studies, questions remain about local immune characteristics in human CP. We profiled cell control organ donors and CP patients including those with hereditary idiopathic undergoing total pancreatectomy islet autotransplantation. Flow cytometric analysis revealed a significant increase the frequency of CD68+ macrophages In contrast, samples showed CD3+ T frequency,...
Among drug-induced adverse events, pancreatitis is life-threatening and results in substantial morbidity. A prototype example the caused by asparaginase, a crucial drug used to treat acute lymphoblastic leukemia (ALL). Here, we systems approach identify factors affecting asparaginase-associated (AAP). Connectivity Map analysis of transcriptomic data showed that asparaginase-induced gene signatures were potentially reversed retinoids (vitamin its analogs). Analysis large electronic health...
Transient receptor potential cation channel, subfamily V, member 6 (TRPV6) is an epithelial Ca2+ channel protein expressed in calcium absorbing organs. In the present study, we investigated expression and regulation of uterine placental TRPV6 during gestation rodents. Uterine peaked at pregnancy day (P) 0.5, P5.5 and, P13.5 was detected epithelium glands rats, while mRNA levels increased mid-gestation. rats appear to cyclically change pregnancy, suggesting that may participate implantation...
All-trans Retinoic acid (RA) and its derivatives are potent therapeutics for immunological functions including wound repair. However, the molecular mechanism of RA modulation in innate immunity is poorly understood, especially macrophages. We found that topical application significantly improves healing IL-4 synergistically activate Arg1, a critical gene tissue repair, M2 polarized This involves feed forward regulation Raldh2, rate-limiting enzyme biosynthesis, requires Med25 to coordinate...
To investigate the antiallergic effect of rhizome Anemarrhena asphodeloides (AA, family Liliaceae), which was found to inhibit mouse passive cutaneous anaphylaxis (PCA) reaction induced by antigen-immunoglobulin E (IgE) complex in preliminary experiments, main steroidal saponins, timosaponins AIII, BIII, and D, were isolated their inhibitory effects against PCA scratching behaviors investigated mice. Oral administration three sapogenins blocked behaviors, timosaponin AIII most potent....
Osteolytic bone diseases, such as osteoporosis, are characterized by diminished quality and increased fracture risk. The therapeutic challenge remains to maintain homeostasis with a balance between osteoclast-mediated resorption osteoblast-mediated formation. Osteoclasts formed the fusion of monocyte/macrophage-derived precursors. Here we report, our knowledge for first time, that receptor-interacting protein 140 (RIP140) expression in osteoclast precursors its regulation crucial...