A5035051392- Epilepsy research and treatment
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Pharmacological Effects and Toxicity Studies
- Muscle activation and electromyography studies
- Trigeminal Neuralgia and Treatments
- Pain Mechanisms and Treatments
- Motor Control and Adaptation
- Parkinson's Disease Mechanisms and Treatments
- Vestibular and auditory disorders
- EEG and Brain-Computer Interfaces
- Genetic Neurodegenerative Diseases
- Neural dynamics and brain function
- Migraine and Headache Studies
- Autoimmune Neurological Disorders and Treatments
- Neuroscience and Neural Engineering
- Genetics and Neurodevelopmental Disorders
- Glycogen Storage Diseases and Myoclonus
- Laser Applications in Dentistry and Medicine
- Peripheral Neuropathies and Disorders
- Metabolism and Genetic Disorders
- Ophthalmology and Eye Disorders
Universidade Federal do Rio Grande
2025
Sapienza University of Rome
2013-2022
Policlinico Umberto I
2006-2021
Queen Mary University of London
2017
Center for Neuroscience and Cognitive Systems
2015
Istituto Neurologico Mediterraneo
2003-2012
University of Verona
1997-2009
Universidad Nacional de Córdoba
2001-2007
Neurological Surgery
2007
Istituto Pasteur
2005
1. The silent period evoked in the first dorsal interosseous (FDI) muscle after electrical and magnetic transcranial stimulation (TCS), of cervicomedullary junction ulnar nerve was studied ten healthy subjects. 2. With maximum‐intensity shocks, average duration 200 ms TCS, 300 43 at 100 peripheral stimulation. 3. period, amplitude motor‐evoked potential, twitch force produced were compared increasing intensities TCS. When stimulus strength increased from 30 to 70% stimulator output,...
DIRECT currents (DC) applied directly to central nervous system structures produce substantial and long-lasting effects in animal experiments. We tested the functional of very weak scalp DC (< 0.5 mA, 7 s) on human motor cortex by assessing changes potentials evoked transcranial magnetic brain stimulation. performed four different experiments 15 healthy volunteers. Our findings led conclusion that such mA) anodal DC, alternated with a cathodal significantly depresses excitability cortex,...
<h3>Objective:</h3> To assess incidence and predictors of acute symptomatic seizures in a prospective cohort patients with first stroke. <h3>Methods:</h3> Patients stroke hospitalized 31 Italian centers were recruited. Relevant demographic data, disease characteristics, risk factors collected. Acute (≤7 days) recorded correlated to age, gender, family history epilepsy, vascular factors. <h3>Results:</h3> A total 714 (315 women, 399 men; age 27–97 years) enrolled. 609 (85.3%) had cerebral...
The silent period after contralateral and ipsilateral transcranial magnetic brain stimulation was studied in patients with Parkinson's disease before dopaminergic anticholinergic therapy; normal subjects L-dopa administration drug-induced parkinsonism. In the also peripheral nerve stimulation. cortical shorter than subjects. prolonged Biperiden subjects, produced similar but smaller changes. parkinsonism did not change drug administration. conclusion is abnormal Dopaminergic drugs modulate...
We studied the performance of sequential arm movements in 14 patients with Parkinson's disease, nine Huntington's disease and seven dystonia. The results were compared those from normal subjects. Subjects had to perform each movement sequence as fast possible, stopping briefly possible between two successive movements. In one set experiments, drew four different geometrical patterns a counter-clockwise direction. consisted two, three, five segments identical length. second set, subjects...
The activity of motor cortical inhibitory circuits was studied with paired transcranial magnetic stimuli in 16 patients Parkinson's disease 'off' therapy, five and 'on' 11 normal subjects. Paired were delivered at short (3-20 ms) as well long (100-250 intervals during slight voluntary contraction. intensity the conditioning stimulus subthreshold (80%) short, suprathreshold (150%) intervals. In addition, silent period following a single shock given 150% threshold measured. With interstimulus...
To find out whether botulinum toxin alters the excitability of cortical motor areas, we studied intracortical inhibition with transcranial magnetic stimulation in patients upper limb dystonia before, 1 month after, and 3 months after injection type A affected muscles. Eleven normal subjects 12 involving limbs (7 generalized dystonia, 2 segmental focal dystonia) were studied. Patients assessed clinically Dystonia Movement Scale. Paired stimuli delivered by two Magstim 200 stimulators...
Patients with upper limb dystonia have abnormal reciprocal inhibition between flexor and extensor forearm muscles. To see whether botulinum toxin treatment alters segmental motor system function, we studied muscles, before after injection in muscles 12 patients dystonia. Reciprocal was by conditioning the H reflex flexors a radial nerve stimulus delivered at range of time intervals. Botulinum improved Before injection, dystonic had decreased second phase inhibition. After injections this...
Abstract From 1976 to 1986, 681 patients with drug-refractory trigeminal neuralgia (TN)—typical in 641, symptomatic of multiple sclerosis 23 and tumor 10, atypical 5, postherpetic 2—were treated various percutaneous procedures. Controlled differential thermocoagulation the gasserian ganglion and/or retrogasserian rootlets was performed 533 patients; glycerolization cistern 32; compression by balloon catheter 159, Results complications each procedure are assessed at a mean follow-up 6.5 years...
The precise localizations of the neural substrates voluntary inhibition are still debated. It has been hypothesized that, in humans, this executive function relies upon a right-lateralized pathway comprising inferior frontal gyrus and presupplementary motor area, which would control processes for movement acting through right subthalamic nucleus (STN). We assessed role STN, via countermanding reaching task, 10 Parkinson's patients receiving high-frequency electrical stimulation STN both...
Our current understanding of brainstem reflex physiology comes chiefly from the classic anatomical–functional correlation studies that traced central circuits underlying reflexes and establishing abnormalities as markers for specific areas lesion. These nevertheless had disadvantage deriving post-mortem findings in only a few patients. We developed voxel-based model human designed to import normalize MRIs, select groups patients with or without given dysfunction, compare their MRIs...
Abstract Cortical inhibitory mechanisms were investgated with the technique of paired transcranial magnetic stimulation in 10 patients dystonia right arm: six had focal, task‐specific (writer's cramp) and three segmental one generalized dystonia. Paired stimuli delivered a conditioning‐test design during slight voluntary activation target muscle, subthreshold conditioning at short intervals (3‐20 ms) suprathreshold long (100‐250 ms). The amount inhibition interstimulus did not differ...
While research on human sensory processing shows that warm input is conveyed from the periphery by specific, unmyelinated primary neurons, its pathways in central nervous system (CNS) remain unclear. To gain physiological information spinal convey warmth or nociceptive sensations, 15 healthy subjects, we studied cerebral evoked responses and reaction times response to laser stimuli selectively exciting Adelta nociceptors C receptors at different levels along spine. minimize conduction...
1. The differential block of cutaneous nerve fibres has been achieved with a simple method electrical stimulation, employing single pair active electrodes. 2. allows the selective activation 95% small myelinated (delta) axons, without larger (beta) ones; and unmyelinated (C) fibres, A fibre activation. Asynchronous firing axons was absent in majority experiments. 3. employs triangularly shaped pulses, steep rise front slow exponential decay. outward flow current at cathode fires conducted...
Transcranial stimulation (TCS) in intact human subjects was used to investigate the corticobulbar projections and functional organization of trigeminal motor system. Both electrical (with anode overlying face area cortex) magnetic TCS coil at vertex) excite upper motoneurons projecting nucleus, evoking potentials (C-MEPs) jaw-closing suprahyoid muscles, but only during voluntary contraction. At least 30% are reached by direct fast-conducting fibres; these mainly crossed. Suprahyoid also...
The trigeminal reflexes (corneal reflex, blink masseter inhibitory periods, jaw-jerk) and far field scalp potentials (nerve, root, brainstem, subcortical) evoked by percutaneous infraorbital stimulation were recorded in 30 patients with "idiopathic" neuralgia (ITN) 20 "symptomatic" pain (STP): seven postherpetic neuralgia, five multiple sclerosis, four tumour, two vascular malformation, one Tolosa-Hunt syndrome, traumatic fracture. All the STP of those ITN had reflex abnormalities; 80% 30%...
Abstract Objective Valproate (VPA) use in women with idiopathic generalized epilepsy (IGE) who are of reproductive age has been a matter concern and debate, which eventually led to the recent restrictions by regulatory agencies. The aim our study was investigate relationship between VPA avoidance/switch seizure outcome childbearing potential. Methods We retrospectively reviewed data from female patients IGE, 13‐50 years age, followed since 1980. evaluated prescription habits, rate switch for...
Abstract By analyzing the kinematics of repetitive, constant‐amplitude, finger oppositions, we compared impairment individual and nonindividual movements in patients with Parkinson's disease. In one task, subjects tapped only index against thumb (individual oppositions); other they all four fingers together pad (nonindividual oppositions). We used an optoelectronic motion analysis system to record three‐dimensional space recorded three 5‐second trials for each task. counted how many...