A5036938163- Enzyme Structure and Function
- Glycosylation and Glycoproteins Research
- Toxin Mechanisms and Immunotoxins
- Infant Nutrition and Health
- Chemical Synthesis and Analysis
- Venomous Animal Envenomation and Studies
- Enzyme Production and Characterization
- RNA and protein synthesis mechanisms
- Transgenic Plants and Applications
- Protein Structure and Dynamics
- Carbohydrate Chemistry and Synthesis
- Viral gastroenteritis research and epidemiology
- Antimicrobial Peptides and Activities
- Biochemical effects in animals
- RNA Interference and Gene Delivery
- Crystal structures of chemical compounds
- Peptidase Inhibition and Analysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Biochemical and Molecular Research
- Synthesis and biological activity
- Porphyrin Metabolism and Disorders
- Computational Drug Discovery Methods
- Biochemical and Structural Characterization
- Ion channel regulation and function
- Protein Kinase Regulation and GTPase Signaling
All India Institute of Medical Sciences
2016-2025
Sarojini Naidu Medical College
2013-2024
Amity University
2024
University of Pennsylvania
2023
Himachal Pradesh University
2023
Institut de Biologie Structurale
2008
Université Joseph Fourier
2008
Laboratoire de Cristallographie et Sciences des Matériaux
2008
Chang Gung University
2004
Department of Science and Technology
2004
Aggregation of unfolded proteins occurs mainly through the exposed hydrophobic surfaces. Any mechanism inhibition this aggregation should explain prevention these interactions. Though arginine is prevalently used as an suppressor, its action not clearly understood. We propose a based on interactions arginine.We have analyzed solution for hydrotropic effect by pyrene solubility and presence environment 1-anilino-8-naphthalene sulfonic acid fluorescence. Mass spectroscopic analyses show that...
Lactoferrin is a multifunctional, iron-binding glycoprotein which displays wide array of modes action to execute its primary antimicrobial function. It contains various peptides are released upon hydrolysis by proteases. These display similarity with the cationic found in nature. In current scenario increasing resistance antibiotics, there need for discovery novel drugs. this context, structural and functional perspectives on some N-lobe lactoferrin have been reviewed. This paper provides...
SARS-CoV-2 is the causative agent of COVID-19 and has been declared as pandemic disease by World Health Organization. Lack targeted therapeutics vaccines for COVID-2019 have triggered scientific community to develop new or drugs against this novel virus. Many synthetic compounds antimalarial are undergoing clinical trials. The traditional medical practitioners widely use Indian medicinal plant Withania somnifera (Ashwagandha) natural constituents, called withanolides curing various diseases....
The accumulation of massive data in the plethora Cheminformatics databases has made role big and artificial intelligence (AI) indispensable drug design. This necessitated development newer algorithms architectures to mine these fulfil specific needs various discovery processes such as virtual screening, de novo molecule design this era. deep learning neural networks their variants with corresponding increase chemical resulted a paradigm shift information mining pertaining space. present...
The purpose of the present paper was to study spectrum stone composition upper urinary tract calculi by X-ray diffraction crystallography technique, in patients managed at All India Institute Medical Sciences.Between 30 April 1998 and 31 March 2003, a total 1050 (900 renal, 150 ureteric) were analyzed. fragments collected after extracorporeal shock-wave lithotripsy, or retrieval endoscopic (percutaneous nephrolithotomy, ureterorenoscopy), laparoscopic various open surgical procedures....
X-ray diffraction data at atomic resolution to 0.98 Å with 136 380 observed unique reflections were collected using a high quality proteinase K crystals grown under microgravity conditions and cryocooled. The structure has been refined anisotropically REFMAC SHELX-97 R-factors of 11.4 12.8%, Rfree-factors 12.4 13.5%, respectively. model coordinates have an overall rms shifts 0.23 relative the same determined room temperature 1.5 resolution. Several regions main chain side chains, which not...
Cross-linked enzyme aggregates (CLEAs) are prepared by precipitation of an and then chemical cross-linking the precipitate. Three CLEAs lipase with glutaraldehyde concentrations 10 mM (CLEA A), 40 B) 60 C) were prepared. Studies show that there is a trade-off between thermal stability vs transesterification/hydrolysis rate enantioselectivity. The initial rates for transesterification β-citronellol uncross-linked A, B C 243, 167, 102 µmol mg−1 h−1, respectively. Their stabilities in aqueous...