A5080152123- Cancer-related molecular mechanisms research
- Leprosy Research and Treatment
- Immune cells in cancer
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Mycobacterium research and diagnosis
- Oral microbiology and periodontitis research
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Pancreatic function and diabetes
- interferon and immune responses
- Psoriasis: Treatment and Pathogenesis
- Diabetes and associated disorders
- Extracellular vesicles in disease
- Cytomegalovirus and herpesvirus research
- Xenotransplantation and immune response
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Yersinia bacterium, plague, ectoparasites research
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Pluripotent Stem Cells Research
- Chronic Lymphocytic Leukemia Research
- Vector-borne infectious diseases
- Pharmacological Effects of Natural Compounds
University of Illinois Chicago
2020-2025
University of Illinois Urbana-Champaign
2023
University of Minnesota
2017-2021
All India Institute of Medical Sciences
2011-2018
Indiana University School of Medicine
2018
Indiana University
2018
Jamia Millia Islamia
2008-2012
Regulatory B cells are known to exhibit their regulatory functions through Interleukin 10 (IL-10) cytokine which suppresses inflammation. There only a few studies explaining the phenotype and functioning of these in contribution host immunity leprosy. Here, we evaluated role interleukin-10 producing B-cells (Bregs) pathogenesis leprosy assessed immunoregulatory effects on Tregs effector T cells. We found an increased frequency Bregs expression immune modulatory molecules (IL-10, FoxP3 PDL-1)...
Macrophages (Mφ) are long-lived myeloid cells that can polarize towards the proinflammatory M1 or proresolving M2 phenotype to control diverse biological processes such as inflammation, tissue damage, and regeneration. Noncoding RNA a class of nonprotein-coding transcriptome with numerous interdependent roles; however, their functional interaction in regulation Mφ polarization immune responses remain unclear. Here, we show antagonistic relationship between lncRNA (MALAT1) microRNA (miR-30b)...
Background: SARS-CoV-2 infection can lead to long-term health problems affecting multiple body systems termed long COVID. Currently, limited information exists about oral manifestations in COVID-19 patients with healthcare access. Methods: We conducted a sequential, cross-sectional study (December 2020-March 2024) assess how racial/ethnic differences (Black/Hispanic vs White/Asian) and disparities affect non-oral COVID symptoms their relationship vaccination. retrospectively reviewed record...
Purpose: Although the mechanisms underlying herpes simplex virus type-1 (HSV-1) ocular infection have been extensively studied, role of host microRNAs (miRNAs) in pathobiology herpetic keratitis (HK) is not well understood. The aim this study was to identify endogenous miRNA regulators involved progression HSV-1 infection. Methods: C57BL/6 mice were infected with strain McKrae following epithelial debridement, and corneal profiles analyzed at various time points using sequencing (miRNA-seq)....
Though islet transplantation is now being considered as a gold standard to cure type 1 diabetes in patients without the threat of unaware hypoglycemia and severe episode, post-transplantation loss due intra-islet vasculature during isolation process compromises full functionality transplanted mass. Therefore, besides instant blood-mediated inflammatory reaction (IBMIR) induced within first 60 minutes intraportal vein, two weeks avascular window, prior adequate vascularization, responsible...
Macrophages (M φ ) are immune cells that exhibit remarkable functional plasticity. Identification of novel endogenous factors can regulate plasticity and innate functions M will unravel new strategies to curb immune-related diseases. Long non-coding RNAs (lncRNAs) a class endogenous, non-protein coding, regulatory increasingly being associated with various cellular Despite their ubiquity abundance, lncRNA-mediated epigenetic regulation polarization is poorly studied. This study elucidates...
Glutathione S-transferases (GSTs) are an important group of isoenzymes that play essential role in the detoxification carcinogens. Polymorphism at exon 5 GST π family decreases catalytic activity and affects ability enzyme, GSTP1. GSTP1 promoter hypermethylation loss expression frequently observed various types carcinoma. We hypothesized somatic epigenetic modification homozygous mutants increases degree to which breast cancer risk is affected by lifestyle factors dietary habits. The present...
Innate immune response is regulated by tissue resident or infiltrating cells such as macrophages (Mφ) that play critical role in development, homeostasis, and repair of damaged tissue. However, the epigenetic mechanisms regulate Mφ plasticity innate functions are not well understood. Long non-coding RNA (lncRNA) among most abundant class transcriptome but their function myeloid cell biology less explored. In this study, we deciphered regulatory previously uncharacterized lncRNAs polarization...
(Herpes simplex virus type 1 [HSV-1]) infects millions of people globally, manifesting as vesiculo-ulcerative lesions the oral or genital mucosa. After primary infection, establishes latency in peripheral neurons and reactivates sporadically response to various environmental genetic factors. A unique feature herpesviruses is their ability encode tiny noncoding RNAs called microRNA (miRNAs).
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. FoxP3 have been shown to important implications in various diseases. The present study describes the mechanism of action CD4⁺CD25⁺ T cells derived from leprosy patients. Increased molecular interactions with histone deacetylases 7/9 nucleus borderline lepromatous leprosy/lepromatous (BL/LL) patients were found be responsible for FoxP3-driven immune suppression activities during progression leprosy. Further,...
The human leukocyte antigen G1 (HLA-G1), a non-classical class I major histocompatibility complex (MHC-I) protein, is potent immunomodulatory molecule at the maternal/fetal interface and other environments to regulate cellular immune response. We created GGTA1