A5060535758- Immune Cell Function and Interaction
- Renin-Angiotensin System Studies
- Yersinia bacterium, plague, ectoparasites research
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Bacillus and Francisella bacterial research
- T-cell and B-cell Immunology
- Vector-borne infectious diseases
- Pharmacological Effects of Natural Compounds
- Electrolyte and hormonal disorders
- Leprosy Research and Treatment
- CAR-T cell therapy research
- Hepatitis B Virus Studies
- Renal Transplantation Outcomes and Treatments
- Pancreatic function and diabetes
- Acute Kidney Injury Research
- Renal Diseases and Glomerulopathies
- Hormonal Regulation and Hypertension
- Cholinesterase and Neurodegenerative Diseases
- Virus-based gene therapy research
- Cancer Immunotherapy and Biomarkers
- Anesthesia and Neurotoxicity Research
- Fibroblast Growth Factor Research
- Enhanced Recovery After Surgery
- Connective Tissue Growth Factor Research
Southwestern Medical Center
2024
University of Houston
2020-2024
The University of Texas Southwestern Medical Center
2024
Albert Einstein College of Medicine
2014-2019
All India Institute of Medical Sciences
2010-2017
Bipar
2013-2014
Royal College of Surgeons in Ireland
2006
Endotoxin such as lipopolysaccharide (LPS) induces acute kidney injury (AKI), which is a risk factor for and often leads to chronic diseases. The present study revealed that bone marrow-derived macrophage activation of the angiotensin II type 2 receptor (AT R) contributes anti-inflammation partial renoprotection against early stages LPS-induced AKI. Since AT R an emerging anti-inflammatory organ-protective target, this advances our understanding R’s mechanisms associated with renoprotection.
Kidney infiltrating immune cells such as monocytes, neutrophils, and T play critical roles in renal ischemia-reperfusion (IR) injury repair. Recently, the angiotensin II type 2 receptor (AT
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. FoxP3 have been shown to important implications in various diseases. The present study describes the mechanism of action CD4⁺CD25⁺ T cells derived from leprosy patients. Increased molecular interactions with histone deacetylases 7/9 nucleus borderline lepromatous leprosy/lepromatous (BL/LL) patients were found be responsible for FoxP3-driven immune suppression activities during progression leprosy. Further,...
Several β cell antigens recognized by T cells in the non-obese diabetic (NOD) mouse model of type 1 diabetes (T1D) are also targets human disease. While numerous antigen-specific therapies prevent NOD mice, successful translation rodent findings to patients has been difficult. A leucocyte antigen (HLA)-transgenic incorporating cell-specific might provide a better platform for evaluating therapies. The ability study such is limited their low frequency peripheral blood and difficulty obtaining...
Proteinuria is a risk factor for and consequence of kidney injury. Angiotensin II type 2 receptor (AT2R) an emerging reno-protective target anti-proteinuric under pathological conditions, including high salt-fed obese animals. However, the mechanisms remain unknown, particularly whether activity AT2R independent its anti-hypertensive anti-inflammatory effects. In present study, Zucker rats were fed sodium (4%) diet (HSD) 48 h, time in which blood pressure does not change. HSD caused...
Abstract Type 1 diabetes (T1D) is characterized by T cell–mediated destruction of the insulin-producing β cells pancreatic islets. Among loci associated with T1D risk, those most predisposing are found in MHC region. HLA-B*39:06 class I allele and an early age onset. To establish NOD mouse model for study HLA-B*39:06, we expressed it absence murine MHC. was able to mediate development CD8 cells, support lymphocytic infiltration islets, confer susceptibility. Because reduced thymic insulin...
T-cells play a critical role in resistance to malaria, not only because they function as helper cells for an antibody response, but also serve effector cells. Such cellular immunity is directly implicated protection from sporozoites well blood stage parasites. The aim of this study was induce cell mediated immune responses peptide antigens Plasmodium vivax co-encapsulated with CpG oligodeoxynucleotide (ODN) microparticles. In the present study, we have investigated immunomodulatory effects...
Abstract Yersinia pestis is a facultative bacterium that can survive and proliferate inside host macrophages cause bubonic, pneumonic systemic infection. Apart from humoral response, cell‐mediated protection plays major role in combating the disease. F raction 1 capsular antigen ( 1‐ A g) of Y . has long been exploited as vaccine candidate. In this study, 1‐multiple antigenic peptide MAP or )‐specific cytokine responses were studied murine model. consisting three B one T cell epitopes...
Adoptive cell immunotherapy for human diseases, including the use of T cells modified to express an anti-tumour T-cell receptor (TCR) or chimeric antigen receptor, is showing promise as effective treatment modality. Further advances would be accelerated by availability a mouse model that permit engineering protocols and proposed genetic modifications evaluated in vivo. NOD-scid IL2rγ(null) (NSG) mice accept engraftment mature cells; however, long-term evaluation transferred has been hampered...
Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell-mediated destruction of the pancreatic islet beta cells. Multiple genetic loci contribute to susceptibility in humans, with most responsible locus being major histocompatibility complex (MHC). Certain MHC alleles are predisposing, including common HLA-A(∗)02:01. After MHC, conferring strongest T1D regulatory region insulin gene, and associated reduced thymic expression predisposing. Mice express two genes, Ins1 Ins2....