A5060302919- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Receptor Mechanisms and Signaling
- Ion Transport and Channel Regulation
- Nitric Oxide and Endothelin Effects
- Electrolyte and hormonal disorders
- Sodium Intake and Health
- Adipose Tissue and Metabolism
- Trace Elements in Health
- Blood Pressure and Hypertension Studies
- Apelin-related biomedical research
- Heavy Metal Exposure and Toxicity
- Acute Kidney Injury Research
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pancreatic function and diabetes
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Adenosine and Purinergic Signaling
- Neuropeptides and Animal Physiology
- Renal Diseases and Glomerulopathies
- Protein Kinase Regulation and GTPase Signaling
- Agricultural Science and Fertilization
- Diabetes Treatment and Management
University of Houston
2016-2025
Florida College
2022
Uppsala University
2022
University of Cape Town
2022
Australian Regenerative Medicine Institute
2022
Monash University
2022
Maastricht University
2022
University of Southern Denmark
2017-2022
Charité - Universitätsmedizin Berlin
2022
Humboldt-Universität zu Berlin
2022
Plasma trimethylamine-N-oxide (TMAO), a product of intestinal microbial metabolism dietary phosphatidylcholine has been recently associated with atherosclerosis and increased risk cardiovascular diseases (CVD) in rodents humans. However, the molecular mechanisms how TMAO induces CVD progression are still unclear. The present study tested whether NLRP3 inflammasome formation activation thereby contributes to endothelial injury initiating atherogenesis.Inflammasome was determined by confocal...
Intraperitoneal administration of cadmium acetate (Cd2+, 0.4 mg/kg) to rats daily for 30 days was found inhibit the activity superoxide dismutase (SOD), increase endogenous levels lipid peroxides and peroxidation in liver kidney tissues. Addition varying concentrations Cd2+ (10-100 microM) vitro also inhibited SOD both It appears that inhibition could be due direct interaction with enzyme molecule. Lipid reaction increased after addition fresh homogenate these tissues, however, it did not...
The angiotensin type 2 receptor (AT2R) has been shown to lower inflammation in the kidney. However, role of anti-inflammatory cytokine interleukin (IL)-10 AT2R-mediated attenuation not elucidated. We hypothesized that AT2R activation is renoprotective by directly increasing levels IL-10 kidney via nitric oxide (NO) signaling. For vitro studies, human proximal tubule epithelial cell-line (human kidney-2 [HK-2]) was activated with lipopolysaccharide (10 μg/mL) and agonist C21 (1 μmol/L) for 24...
Inflammation and oxidative stress are believed to contribute hypertension in obesity/diabetes. Recently, we reported a role for the AT 2 receptor blood pressure control obese Zucker rats. However, of receptors inflammation obesity is not known. Therefore, present study, tested effects agonist CGP-42112A on rats compared them their lean counterparts. Rats were systemically treated with either vehicle (control) or (1 μg·kg −1 ·min ; osmotic pump) wk. Markers (CRP, MCP-1, TNF-α, IL-6) (HO-1,...
The actions of angiotensin II type 2 receptor (AT2R) and the Mas (MasR) are complex but show similar pronatriuretic function; particularly, AT2R expression natriuretic function enhanced in obese/diabetic rat kidney. In light some reports suggesting a potential positive interaction between these receptors, we tested hypothesis that renal MasR physically interact interdependent to stimulate cell signaling promote natriuresis obese rats. We found infusion agonist C21 Zucker rats (OZR) increased...
High-sodium intake is a risk factor for the pathogenesis of hypertension, especially in obesity. The present study designed to investigate whether angiotensin type 2 receptor (AT R) activation with selective agonist C21 prevents high-sodium diet (HSD)-induced hypertension obese animals. Male rats were treated AT R (1 mg·kg −1 ·day , oral) while maintained on either normal-sodium (NSD; 0.4%) or HSD (4%) wk. Radiotelemetric recording showed time-dependent increase systolic blood pressure...
Background and Purpose We others have previously shown that ADGRF1, an adhesion G protein‐coupled receptor, is overexpressed associated with poor survival in many cancers, including human epidermal growth factor receptor‐2 (HER2) breast cancer (BC). Also, we reported the tumour‐promoting function of ADGRF1 using preclinical models HER2+ BC. In this study, investigated effect overexpression orthotopic vivo model as well downstream signalling Experimental Approach utilized a doxycycline...
ABSTRACT Ibezapolstat (IBZ), a first-in-class antibiotic targeting the PolC-type DNA polymerase III alpha-subunit (PolC) in low G + C bacteria, is clinical development for treatment of Clostridioides difficile infection (CDI). In phase 2 trials, IBZ had potent activity against C. while sparing or causing regrowth Lachnospiraceae, Oscillospiraceae, and Erysipelotrichales, common commensal bacteria. The purpose this study was to utilize silico approaches better interpret narrower than expected...
Recently, there has been a growing interest in studying the role of angiotensin II type-2 (AT 2 ) receptor renal/cardiovascular function pathological conditions. The present study was designed to determine functional AT receptors on natriuresis/diuresis and compare level tubular expression obese lean Zucker rats (12 weeks old). Under anesthesia, candesartan (angiotensin type 1 [AT ]–specific antagonist; 100 μg/kg bolus) produced greater degree than rats. specific antagonist PD123319 (50 per...
Angiotensin II AT 2 receptors act as a functional antagonist for the 1 in various tissues. We previously reported that activation of renal promotes natriuresis and diuresis; however, mechanism is not known. The present study was designed to investigate whether affects activity Na + -K -ATPase (NKA), an active tubular sodium transporter, proximal tubules isolated from Sprague-Dawley rats. receptor agonist CGP-42112 (10 −10 -10 −7 M) produced dose-dependent inhibition NKA (9–38%); attenuated...
The dopamine DA1 receptor transduces its signal via adenylyl cyclase and phospholipase C in the renal proximal tubule, which has been suggested to be defective at level of receptor-G protein coupling spontaneously hypertensive rats (SHR). We prepared basolateral membranes from Wistar-Kyoto (WKY) SHR determine with G proteins, especially G(q/11). Fenoldopam, a DA1-receptor agonist, produced time- concentration-dependent stimulation 35S-labeled guanosine 5'-O-(3-thiotriphosphate)...
Abstract There is a growing interest in the use of soil microbial inoculants as an alternative biological approach to a) improve quality, b) enhance growth, yield and quality crops, c) reduce inputs chemical fertilizers pesticides agriculture worldwide. One such product that has received considerable attention, Effective Microorganisms or EM; it consists mixed cultures beneficial microorganisms. A long-term field experiment was conducted at Faisalabad, Pakistan determine agronomic economic...
In the present study, using porcine coronary artery rings in vitro, we examined role of nitric oxide (NO) pathway endothelium-dependent vasorelaxant effects 5'-uronamide adenosine agonists, 5'-(N-ethylcarboxamido)adenosine (NECA) and 2-[p-(2-carboxyethyl)]phenylethyl-amino-5'-N-ethylcarboxamidoadenosine (CGS-21680) as opposed to endothelium-independent actions C2- N6-substituted analogues, 2-chloroadenosine (CAD) N6-cyclopentyladenosine (CPA). The NO synthase inhibitor,...
Intraperitioneal administration of 0.4 mg/kg Cadmium (Cd) daily for 45 days was found to inhibit the activities glutathione peroxidase and catalase in liver, kidney, testis various brain regions at different time intervals. The magnitude inhibition increased with period exposure. Cd produced significant 15 kidney cerebellum only; however, enzyme activity be decreased all tissues, except corpus striatum, 30 Hippocampal remained unaltered throughout experiment. Catalase inhibited tissues...