A5089066727- Advanced biosensing and bioanalysis techniques
- Bladder and Urothelial Cancer Treatments
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Cell Adhesion Molecules Research
- Advanced Proteomics Techniques and Applications
- Neurogenetic and Muscular Disorders Research
- Metabolism, Diabetes, and Cancer
- Receptor Mechanisms and Signaling
- Cancer Cells and Metastasis
- Urinary and Genital Oncology Studies
- Sphingolipid Metabolism and Signaling
- HER2/EGFR in Cancer Research
- Cellular transport and secretion
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Endoplasmic Reticulum Stress and Disease
Baylor College of Medicine
2024-2025
Bladder cancer (BLCA) mortality is higher in African American (AA) patients compared with European (EA) patients, but the molecular mechanism underlying race-specific differences are unknown. To address this gap, we conducted comprehensive RNA-Seq, proteomics, and metabolomics analysis of BLCA tumors from AA EA. Our findings reveal a distinct metabolic phenotype characterized by elevated mitochondrial oxidative phosphorylation (OXPHOS), particularly through activation complex I. The results...
Background and Purpose We others have previously shown that ADGRF1, an adhesion G protein‐coupled receptor, is overexpressed associated with poor survival in many cancers, including human epidermal growth factor receptor‐2 (HER2) breast cancer (BC). Also, we reported the tumour‐promoting function of ADGRF1 using preclinical models HER2+ BC. In this study, investigated effect overexpression orthotopic vivo model as well downstream signalling Experimental Approach utilized a doxycycline...
A great deal of attention is currently being paid to strategies aiming at uncovering the biology four-stranded nucleic acid structure G-quadruplex (G4) via their stabilization in cells using G4-specific ligands. The conventional definition chemical implies that a complete assessment G4 can only be achieved through implementation complementary approach involving destabilization cellular G4s by ad hoc molecular effectors. We report here on an unprecedented comparison consequences pyridostatin...
Abstract Background Tumor recurrence and metastatic progression remains the leading cause for breast cancer related mortalities. However, proteomes of patient- matched primary (BC) lesions have not yet been identified, due to lack clinically annotated longitudinal samples. In this study, we evaluated global-proteomic landscape BC patients with without distant metastasis as well compared proteome disease its corresponding BC, within same patient. Methods We performed mass spectrometry-based...