A5063628378- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- Diabetes Management and Research
- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- Planarian Biology and Electrostimulation
- Acute Lymphoblastic Leukemia research
- vaccines and immunoinformatics approaches
- Acute Myeloid Leukemia Research
- T-cell and B-cell Immunology
- Tissue Engineering and Regenerative Medicine
- Immunotherapy and Immune Responses
- Hematopoietic Stem Cell Transplantation
Albert Einstein College of Medicine
2014-2024
NYU Langone Health
2023
Rutgers, The State University of New Jersey
2011
Columbia University
2009
Abstract Type 1 diabetes (T1D) is characterized by T cell–mediated destruction of the insulin-producing β cells pancreatic islets. Among loci associated with T1D risk, those most predisposing are found in MHC region. HLA-B*39:06 class I allele and an early age onset. To establish NOD mouse model for study HLA-B*39:06, we expressed it absence murine MHC. was able to mediate development CD8 cells, support lymphocytic infiltration islets, confer susceptibility. Because reduced thymic insulin...
Improved mouse models for type 1 diabetes (T1D) therapy development are needed. T1D susceptibility is restored to normally resistant NOD.β2m−/− mice transgenically expressing human disease–associated HLA-A*02:01 or HLA-B*39:06 class I molecules in place of their murine counterparts. dependent on pathogenic CD8+ T-cell responses mediated by these variants. NOD.β2m−/−-A2.1 were previously used identify β-cell autoantigens presented this variant T cells and testing therapies attenuate such...
Summary Type 1 diabetes is characterized by T‐cell‐mediated destruction of the insulin‐producing β cells in pancreatic islets. A number islet antigens recognized CD 8 T that contribute to disease pathogenesis non‐obese diabetic ( NOD ) mice have been identified; however, antigenic specificities majority islet‐infiltrating yet be determined. The primary goal current study was identify candidate based on level and specificity expression their genes mouse islets cell line MIN 6. Peptides...
Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell-mediated destruction of the pancreatic islet beta cells. Multiple genetic loci contribute to susceptibility in humans, with most responsible locus being major histocompatibility complex (MHC). Certain MHC alleles are predisposing, including common HLA-A(∗)02:01. After MHC, conferring strongest T1D regulatory region insulin gene, and associated reduced thymic expression predisposing. Mice express two genes, Ins1 Ins2....
Type 1 diabetes (T1D) is an autoimmune disease involving T cell-mediated destruction of the insulin-producing beta cells in pancreatic islets Langerhans. CD8
Abstract Dendritic cells (DCs) are crucial for the production of adaptive immune responses to disease-causing microbes. However, in steady state (i.e., absence an infection or when Ags experimentally delivered without a DC-activating adjuvant), DCs present T tolerogenic manner and important establishment peripheral tolerance. Delivery islet using Ag-linked Abs DC endocytic receptor CD205 has shown promise NOD mouse model type 1 diabetes (T1D). It is note, however, that all myeloid express...
Cell replacement therapies, which utilize renewable stem cell sources, hold tremendous potential to treat a wide range of degenerative diseases. Although many studies have established techniques successfully differentiate cells into different mature lineages, their practicality is limited by the lack control during differentiation process and low yields differentiated cells. In order address these issues, we previously murine embryonic alginate-poly-L-lysine microencapsulation system [1]. We...
ABSTRACT Type 1 diabetes (T1D) is characterized by T cell-mediated destruction of the insulin-producing βcells pancreatic islets. Among loci associated with T1D risk, those most predisposing are found in MHC region. HLA-B*39:06 class I allele and an early age onset. To establish NOD mouse model for study HLA-B*39:06, we expressed it absence murine MHC. was able to mediate development CD8 cells, support lymphocytic infiltration islets, confer susceptibility. Because reduced thymic insulin...